Search Results - "Guo, Yizhen"

Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents by Wu, Puhua, Zhou, Yan, Guo, Yizhen, Zhang, Shao-Lin, Tam, Kin Yip

“…•Recent development of hMCTs inhibitors targeting cancer metabolism is described.•Structural information of hMCT1 and hMCT4 is summarized for rational…”
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One Stone Four Birds: A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy by Hong, Chao, Liang, Jianming, Xia, Jiaxuan, Zhu, Ying, Guo, Yizhen, Wang, Anni, Lu, Chunyi, Ren, Hongwei, Chen, Chen, Li, Shiyi, Wang, Dan, Zhan, Huaxing, Wang, Jianxin

“…Highlights A ginsenoside Rh2-based multifunctional liposome system (Rh2-lipo) was innovatively developed. Rh2-lipo not only innovatively challenges the…”
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In Vitro/In Vivo Metabolism of Ginsenoside Rg5 in Rat Using Ultra-Performance Liquid Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry by Hong, Chao, Yang, Ping, Li, Shuping, Guo, Yizhen, Wang, Dan, Wang, Jianxin

“…: Ginsenoside Rg5 has been proved to have a wide range of pharmacological activities. However, the in vitro and in vivo metabolism pathways of ginsenosides are…”
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Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia by Vu, Trang T, Kim, Kyeongmin, Manna, Millennium, Thomas, Justin, Remaily, Bryan C, Montgomery, Emma J, Costa, Travis, Granchie, Lauren, Xie, Zhiliang, Guo, Yizhen, Chen, Min, Castillo, Alyssa Marie M, Kulp, Samuel K, Mo, Xiaokui, Nimmagadda, Sridhar, Gregorevic, Paul, Owen, Dwight H, Ganesan, Latha P, Mace, Thomas A, Coss, Christopher C, Phelps, Mitch A

“…High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in…”
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746 Cancer cachexia associated Fc receptor expression on leukocytes as potential mechanism of checkpoint inhibitor resistance in patients and in murine cancer models by Remaily, Bryan, Lathrop, Hannah, Thomas, Justin, Kim, Kyeongmin, Vu, Trang, Stanton, Camille, Manna, Millenium, Granchie, Lauren, Xie, Zhiliang, Guo, Yizhen, Owen, Dwight, Kulp, Samuel, Ganesan, Latha, Coss, Chris C, Phelps, Mitch, Mace, Thomas

“…BackgroundCancer cachexia is a multifactorial syndrome characterized by irreversible loss of skeletal muscle and adipose tissue resulting from increased…”
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Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans by Castillo, Alyssa Marie M., Vu, Trang T., Liva, Sophia G., Chen, Min, Xie, Zhiliang, Thomas, Justin, Remaily, Bryan, Guo, Yizhen, Subrayan, Uma L., Costa, Travis, Helms, Timothy H., Irby, Donald J., Kim, Kyeongmin, Owen, Dwight H., Kulp, Samuel K., Mace, Thomas A., Phelps, Mitch A., Coss, Christopher C.

“…Background Monoclonal antibody (mAb) immune checkpoint inhibitor (ICI) therapies have dramatically impacted oncology this past decade. However, only about…”
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Carbon Nanotubes Grown Using Solid Polymer Chemical Vapor Deposition in a Fluidized Bed Reactor with Iron(III) Nitrate, Iron(III) Chloride and Nickel(II) Chloride Catalysts by Wang, Chuhsuan, Chang, Jingshiun, Amatosa, Teodoro, Guo, Yizhen, Lin, Fujen, Yen, Yeewen

“…In this study, multi-walled carbon nanotubes (MW-CNT) were successfully synthesized using a chemical vapor deposition-fluidized bed (CVD-FB), with 10% hydrogen…”
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Targeting glucose metabolism to develop anticancer treatments and therapeutic patents by Zhou, Yan, Guo, Yizhen, Tam, Kin Yip

“…One of the most distinctive hallmarks of cancer cells is increased glucose consumption for aerobic glycolysis, which is called the Warburg effect. In recent…”
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Navigating legal responsibilities in politically connected firms: Insights into the influence of directors' and officers' insurance on litigation risk by Zhang, Xiaojuan, Guo, Yizhen, Chi, Tiancheng

“…Abstract This study aims to investigate how directors' and officers' (D&O) liability insurance, legal responsibilities, and firm political connections…”
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Harnessing traditional Chinese medicine polysaccharides for combatting COVID-19 by Xiao, Zhiyong, Guo, Yizhen, Li, Jingxuan, Jiang, Xuyong, Wu, Fushan, Wang, Ying, Zhang, Yongxiang, Zhou, Wenxia

“…With the global spread of COVID-19 posing ongoing challenges to public health systems, there is an ever-increasing demand for effective therapeutics that can…”
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Advanced nonhomogeneous wind field simulation for offshore Turbines via enhanced A-R scheme by Wu, Yongxin, Guo, Yizhen, Cheng, Haifeng, Chen, Yinying, Li, Bing, Lai, Ying

“…The precise and efficient simulation of the spatial variable wind field is the underpinning of the dynamic response analysis of the wind turbine structure. The…”
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Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer by Hong, Chao, Wang, Dan, Liang, Jianming, Guo, Yizhen, Zhu, Ying, Xia, Jiaxuan, Qin, Jing, Zhan, Huaxing, Wang, Jianxin

“…The clinical treatment of gastric cancer (GC) is hampered by the development of anticancer drug resistance and the unfavorable pharmacokinetics, off-target…”
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Combined inhibition of pyruvate dehydrogenase kinase 1 and hexokinase 2 induces apoptsis in non-small cell lung cancer cell models by Guo, Yizhen, Lu, Xianchen, Zhou, Yan, Chen, Wen-Hua, Tam, Kin Yip

“…Many cancer cells exhibit enhanced glycolysis, which is seen as one of the hallmark metabolic alterations, known as Warburg effect. Substantial evidence shows…”
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Impact of molecular weight and gastrointestinal digestion on the immunomodulatory effects of Lycium barbarum polysaccharides by Guo, Yizhen, Zhao, Xueru, Xiao, Shiqi, Lin, Yanling, Xiao, Zhiyong, Zhou, Wenxia, Zhang, Yongxiang

“…In traditional Chinese medicine, Lycium barbarum is of rich medicinal value, and its polysaccharides are particularly interesting due to their significant…”
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Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing by Zhou, Yan, Guo, Yizhen, Ran, Maoxin, Shan, Wenying, Granchi, Carlotta, Giovannetti, Elisa, Minutolo, Filippo, Peters, Godefridus J., Tam, Kin Yip

“…Lung adenocarcinoma (LUAD) is one of the most prevalent and aggressive types of lung cancer. Metabolic reprogramming plays a critical role in the development…”
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Dichloroacetophenone biphenylsulfone ethers as anticancer pyruvate dehydrogenase kinase inhibitors in non-small cell lung cancer models by Guo, Yizhen, Zhou, Yan, Wu, Puhua, Ran, Maoxin, Xu, Ngai, Shan, Wenying, Sha, Ou, Tam, Kin Yip

“…Pyruvate dehydrogenase kinase 1 (PDK1) is an important metabolic enzyme which is often overexpressed in many types of cancers, including non-small-cell lung…”
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Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance by Ran, Maoxin, Zhou, Yan, Guo, Yizhen, Huang, Ding, Zhang, Shao-Lin, Tam, Kin Yip

“…Lung cancer cells often show elevated levels of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADPH). However, the connections…”
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A Mitochondria-Targeted Phenylbutyric Acid Prodrug Confers Drastically Improved Anticancer Activities by Huang, Ding, Liu, Qingwang, Zhang, Maojie, Guo, Yizhen, Cui, Zhiying, Li, Tao, Luo, Dong, Xu, Biao, Huang, Chao, Guo, Jian, Tam, Kin Yip, Zhang, Min, Zhang, Shao-Lin, He, Yun

“…Phenylbutyric acid (PBA) has been reported as a dual inhibitor of pyruvate dehydrogenase kinases (PDKs) and histone deacetylases (HDACs), exhibiting anticancer…”
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Epigallocatechin gallate circumvents drug‐induced resistance in non‐small‐cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis by Zhou, Yan, Huang, Shiqi, Guo, Yizhen, Ran, Maoxin, Shan, Wenying, Chen, Wen‐Hua, Tam, Kin Yip

“…Upon prolonged use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non‐small‐cell lung cancer (NSCLC), acquired drug resistance…”
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Evaluation on the concentration change of paeoniflorin and glycyrrhizic acid in different formulations of Shaoyao-Gancao-Tang by the tri-level infrared macro-fingerprint spectroscopy and the whole analysis method by Liu, Aoxue, Wang, Jingjuan, Guo, Yizhen, Xiao, Yao, Wang, Yue, Sun, Suqin, Chen, Jianbo

“…As a kind of common prescriptions, Shaoyao-Gancao-Tang (SGT) contains two Chinese herbs with four different proportions which have different clinical efficacy…”
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