Search Results - "Guo, Yansu"

Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10 by Yang, Bin, Li, Shaoyong, Wang, Hongyan, Guo, Yansu, Gessler, Dominic J, Cao, Chunyan, Su, Qin, Kramer, Joshua, Zhong, Li, Ahmed, Seemin Seher, Zhang, Hongwei, He, Ran, Desrosiers, Ronald C, Brown, Robert, Xu, Zuoshang, Gao, Guangping

“…Some recombinant adeno-associated viruses (rAAVs) can cross the neonatal blood–brain barrier (BBB) and efficiently transduce cells of the central nervous…”
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Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice by Yang, Chunxing, Qiao, Tao, Yu, Jia, Wang, Hongyan, Guo, Yansu, Salameh, Johnny, Metterville, Jake, Parsi, Sepideh, Yusuf, Issa, Brown, Robert H, Cai, Huaibin, Xu, Zuoshang

“…Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been reported in amyotrophic lateral sclerosis (ALS),…”
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Relationship of Klotho with cognition and dementia: Results from the NHANES 2011–2014 and Mendelian randomization study by Wu, Yue, Lei, Shaoyuan, Li, Dongxiao, Li, Zhongzhong, Zhang, Yingzhen, Guo, Yansu

“…The relationships of Klotho levels with cognition and dementia are poorly understood. This study aimed to investigate the association between Klotho levels and…”
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Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men by Fan, Zhiliang, Jiang, Hong, Song, Xueqin, Guo, Yansu, Tian, Xinying

“…Objective To investigate whether GSTA1, GSTO2, and GSTZ1 are relevant to an increased risk of amyotrophic lateral sclerosis (ALS) in a Chinese population…”
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Activation of Nuclear Factor Erythroid 2-Related Factor 2 Cytoprotective Signaling by Curcumin Protect Primary Spinal Cord Astrocytes against Oxidative Toxicity by Jiang, Hong, Tian, Xinying, Guo, Yansu, Duan, Weisong, Bu, Hui, Li, Chunyan

“…Oxidative damage plays a critical role in many neurodegenerative diseases. Astrocytes are involved in supporting the survival and protection of neurons against…”
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Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line by Hong, Kun, Li, Yi, Duan, Weisong, Guo, Yansu, Jiang, Hong, Li, Wenju, Li, Chunyan

“…► Full-length TDP-43 and its C-terminal fragments disrupt mitochondrial function and morphology. ► Full-length TDP-43 and truncated TDP-43 are localized in…”
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Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis by Zhao, Jing, Li, Zhihua, Hou, Chengbei, Sun, Fei, Dong, Jing, Chu, Xi, Guo, Yansu

“…Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma…”
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Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS by Li, Dongxiao, Liu, Chong, Yang, Chunxing, Wang, Dan, Wu, Dongxia, Qi, Yinkuang, Su, Qin, Gao, Guangping, Xu, Zuoshang, Guo, Yansu

“…•Slow IT injection of rAAV delivers higher transduction to spinal cord compared with the fast injection.•Fast IT injection delivers higher transduction to…”
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Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis by Zhang, Yingzhen, Chen, Lin, Li, Zhongzhong, Li, Dongxiao, Wu, Yue, Guo, Yansu

“…Endothelin-1 (ET-1), a secreted signaling peptide, is suggested to be involved in multiple actions in various tissues including the brain, but its role in…”
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Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin by Lu, Jinsheng, Duan, Weisong, Guo, Yansu, Jiang, Hong, Li, Zhongyao, Huang, Jing, Hong, Kun, Li, Chunyan

“…Highlights ► Explored mitochondrial dysfunction caused by TDP-43 in pathogenesis of ALS. ► Found mitochondrial complex I could be one of pathogenic targets of…”
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Restoration of abnormal sleep EEG power in patients with insomnia disorder after 1Hz rTMS over left DLPFC by Zhao, Xumeng, Liu, Jiayi, Shao, Ziqiang, Liu, Xiaoyang, Wang, Zhen, Yuan, Kai, Zhang, Bingqian, Li, Yan, Sheng, Xiaona, Zhu, Yifei, Guo, Yansu

“…Hyperarousal has been a significant pathophysiological theory related to insomnia disorder (ID), characterized by excessive cortical activation and abnormal…”
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Basic and translational aging research in China: present and future by He, Xiaojuan, Song, Moshi, Qu, Jing, Guo, Yansu, Cao, Heqi, Sun, Ruijuan, Liu, Guang-Hui, Shen, Yong, Group, Major Program Expert

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The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model by Guo, Yansu, Zhang, Yuesheng, Wen, Di, Duan, Weisong, An, Ting, Shi, Pengxiao, Wang, Jingjing, Li, Zhongyao, Chen, Xiaoyu, Li, Chunyan

“…Oxidative stress is associated with the pathogenesis of amyotrophic lateral sclerosis (ALS). Nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant…”
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Food restriction-induced autophagy modulates degradation of mutant SOD1 in an amyotrophic lateral sclerosis mouse model by Zhang, Kunxi, Shi, Pengxiao, An, Ting, Wang, Qian, Wang, Jingjing, Li, Zhongyao, Duan, Weisong, Li, Chunyan, Guo, Yansu

“…Abstract Autophagy dysregulation has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). The expression of LC3II and sequestosome 1…”
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Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level by Yu, Jixu, Jia, Yaqiong, Guo, Yansu, Chang, Geng, Duan, Weisong, Sun, Mengmeng, Li, Bin, Li, Chunyan

“…Epigallocatechin-3-gallate (EGCG) is a major component of green tea polyphenols which displays potential properties of anticancer and neuroprotection. Here we…”
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Central nervous system damage due to acute paraquat poisoning: A neuroimaging study with 3.0 T MRI by Wu, Bailin, Song, Bo, Tian, Suzhai, Huo, Shuhua, Cui, Caixia, Guo, Yansu, Liu, Huaijun

“…Paraquat (PQ) is an organic heterocyclic herbicide that is widely used throughout the world. Epidemiological and neuropathological studies have shown that…”
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Central nervous system damage due to acute paraquat poisoning: An experimental study with rat model by Wu, Bailin, Song, Bo, Yang, Haiqing, Huang, Boyuan, Chi, Bo, Guo, Yansu, Liu, Huaijun

“…► We established rat model of acute PQ poisoning. ► PQ led to increased oxidative stress in the neurons. ► PQ led to the activation of microglia in substantia…”
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MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR DNA-binding protein-43 via increase of HO-1 by Duan, Weisong, Guo, Yansu, Jiang, Hong, Yu, Xiujun, Li, Chunyan

“…Abstract In patients with amyotrophic lateral sclerosis (ALS), various mutations were identified in TAR DNA-binding protein-43 (TDP-43). In the present study,…”
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Neuroprotective effects of diallyl trisulfide in SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis by Guo, Yansu, Zhang, Kunxi, Wang, Qian, Li, Zhongyao, Yin, Yunxia, Xu, Qingmei, Duan, Weisong, Li, Chunyan

“…Abstract Diallyl trisulfide (DATS) is one of the major constituents in garlic oil and has been documented to transcriptionally activate phase II enzymes. The…”
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Protective Effect of Combination of Sulforaphane and Riluzole on Glutamate-Mediated Excitotoxicity by Chang, Geng, Guo, Yansu, Jia, Yaqiong, Duan, Weisong, Li, Bin, Yu, Jixu, Li, Chunyan

“…Threohydroxyaspartate (THA) causes glutamate excitotoxicity in motor neurons in organotypic culture of rat spinal cord. Some drugs, including sulforaphane (SF)…”
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