Search Results - "Guo, Xiucai"

Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4 by Guo, Xiucai, Li, Wei, Li, Qingmei, Chen, Yan, Zhao, Guode, Peng, Ying, Zheng, Jiang

“…Tofacitinib (TFT) is an oral JAK inhibitor which has been approved for the treatment of moderately and severely active rheumatoid arthritis. TFT was found to…”
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Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline by Yang, Xiaojing, Li, Weiwei, Sun, Ying, Guo, Xiucai, Huang, Wenlin, Peng, Ying, Zheng, Jiang

“…Many pyrrolizidine alkaloids (PAs) can cause liver injury in animals and humans. Different hepatotoxic PAs can produce similar hepatotoxic effects, but the…”
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Global burden of ischemic stroke attributable to high body mass index in 204 countries and territories, 1990-2021 by Guo, Xiucai, Zhang, Ziping, Yin, Xueyan, QirongXu, Li, Feng, Zhu, Feng

“…A high body mass index (hBMI) is one of the major risk factors for ischemic stroke (IS), although independent estimates of the global burden and trend of IS…”
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Comprehensive evaluation of power quality of coal mine power grid based on equilibrium empowerment and improved grey relational projection method by Guo, Xiucai, Xu, Pengfei, Shao, Xiaoping

“…Aiming at the problem that the current comprehensive evaluation system of power quality is not fully applicable to coal mine power grid, and the load…”
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Trends in deaths and disability-adjusted life-years of stroke attributable to high body-mass index worldwide, 1990-2019 by Guo, Xiucai, Li, Junxiao, Yin, Xueyan, Zhang, Ziping, Zhong, Qiongqiong, Zhu, Feng

“…High body mass index (HBMI) is an independent risk factor for stroke. Previous studies on the incremental burden of the rapid growth of stroke attributable to…”
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Studies on hepatotoxicity and toxicokinetics of colchicine by Guo, Xiucai, Chen, Yan, Li, Qingmei, Yang, Xiaojing, Zhao, Guode, Peng, Ying, Zheng, Jiang

“…Colchicine (COL) is an alkaloid existing in plants of Liliaceous colchicum. It has widely been used in the treatments of many diseases, such as gout, Familial…”
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Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo by Wang, Kai, Lin, Dongju, Guo, Xiucai, Huang, Wenlin, Peng, Ying, Zheng, Jiang

“…Diosbulbin B (DIOB), a hepatotoxic furan-containing compound, is a primary ingredient in L., a common herbal medicine. Metabolic activation is required for…”
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Research on Energy-Saving Optimization Control System of Mine Belt Conveyor by Guo, Xiucai, Liu, Baojun

“…Due to the imbalance of coal mine production, belt conveyors fail to reach full load in most cases, which not only causes waste of electric energy, but also…”
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Design and Implementation of Intelligent Manhole Cover Monitoring System Based on NB-IoT by Guo, Xiucai, Liu, Bingbing, Wang, Lili

“…The problem of stolen and poorly managed gas well covers in cities has become increasingly prominent, and the existing urban manhole cover monitoring system…”
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Simultaneous assessment of endogenous thiol compounds by LC–MS/MS by Sun, Yao, Yao, Tong, Guo, Xiucai, Peng, Ying, Zheng, Jiang

“…•We develop a mass spectrometry-based method for simultaneous assessment of thiol compounds (GSH, CysGly, Hcy, Cys, and NAC).•The approach is sensitive enough…”
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Reply to Letter to Editor from Veeravalli and Dash on “Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4: Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping” by Guo, Xiucai, Hu, Zixia, Li, Wei, Peng, Ying, Zheng, Jiang

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Metabolic Activation and Cytotoxicity of Aloe-Emodin Mediated by Sulfotransferases by Li, Ruihong, Li, Wei, You, Yutong, Guo, Xiucai, Peng, Ying, Zheng, Jiang

“…Aloe-emodin (AE) is a major anthraquinone ingredient of numerous traditional Chinese medicines with a variety of beneficial biological activities in vitro…”
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Identification of Quinone Methide Intermediate Resulting from Metabolic Activation of Icaritin in Vitro and in Vivo by Chen, Yan, Guo, Xiucai, Ma, Yufei, Hu, Xingjia, Peng, Ying, Zheng, Jiang

“…Many herbal medicines such as epimedium have been reported to cause adverse effects, and icaritin is the common aglycone of many glucosides in epimedium. Our…”
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Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase in Vitro by Guo, Xiucai, Jia, Yudi, Han, Lingling, Zhao, Yanhong, Li, Wei, Zhang, Zhengyu, Peng, Ying, Zheng, Jiang

“…Tofacitinib (TFT) is used for the treatment of moderately and severely active rheumatoid arthritis. Unfortunately, TFT was reported to induce leukopenia, and…”
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Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone by Wang, Hui, Feng, Yukun, Wang, Qian, Guo, Xiucai, Huang, Wenlin, Peng, Ying, Zheng, Jiang

“…Benzbromarone (BBR) is a therapeutically useful uricosuric agent but can also cause acute liver injury. The hepato­toxicity of BBR is suggested to be…”
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Metabolite profile analysis and pharmacokinetic study of emodin, baicalin and geniposide in rats by Yu, Jing, Guo, Xiucai, Zhang, Qingqing, Peng, Ying, Zheng, Jiang

“…1. Emodin, baicalin and geniposide are the major bioactive components in Da-Huang, Huang-Qin and Zhi-Zi which are herbal medicines widely used in Asian…”
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Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma by Wei, Minyan, Guo, Xiucai, Tu, Liuxiao, Zou, Qi, Li, Qi, Tang, Chenyi, Chen, Bao, Xu, Yuehong, Wu, Chuanbin

“…Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor…”
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In Vitro and in Vivo Studies of the Metabolic Activation of 8‑Epidiosbulbin E Acetate by Lin, Dongju, Guo, Xiucai, Gao, Huiyuan, Cheng, Li, Cheng, Maosheng, Song, Shaojiang, Peng, Ying, Zheng, Jiang

“…Furanoid 8-epidiosbulbin E acetate (EEA) is a major constituent of herbal medicine Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Our…”
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Lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate by Lin, Dongju, Wang, Kai, Guo, Xiucai, Gao, Huiyuan, Peng, Ying, Zheng, Jiang

“…[Display omitted] •Reactions of EEA-derived cis-enedial with lysine, GSH, or cysteine produced two types of protein adducts, including pyrrole and pyrrolinone…”
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In vitro and in vivo studies of the metabolic activation of chelidonine by Liu, Yuyang, Peng, Ying, Zhang, Zhengyu, Guo, Xiucai, Ji, Mingshan, Zheng, Jiang

“…Chelidonium majus L. is a herbal medicine widely employed in Europe and Western Asia. Chelidonine (CHE) is a major constituent of the herb and has been…”
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