Search Results - "Guo, X. Edward"

Mechanical stress determines the configuration of TGFβ activation in articular cartilage by Zhen, Gehua, Guo, Qiaoyue, Li, Yusheng, Wu, Chuanlong, Zhu, Shouan, Wang, Ruomei, Guo, X. Edward, Kim, Byoung Choul, Huang, Jessie, Hu, Yizhong, Dan, Yang, Wan, Mei, Ha, Taekjip, An, Steven, Cao, Xu

“…Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional…”
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Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones by Jepsen, Karl J, Silva, Matthew J, Vashishth, Deepak, Guo, X Edward, van der Meulen, Marjolein CH

“…ABSTRACT Mice are widely used in studies of skeletal biology, and assessment of their bones by mechanical testing is a critical step when evaluating the…”
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Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1 by Kajimura, Daisuke, Lee, Ha Won, Riley, Kyle J., Arteaga-Solis, Emilio, Ferron, Mathieu, Zhou, Bin, Clarke, Christopher J., Hannun, Yusuf A., DePinho, Ronald A., Guo, X. Edward, Mann, J. John, Karsenty, Gerard

“…The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin…”
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Dependence of mechanical properties of trabecular bone on plate–rod microstructure determined by individual trabecula segmentation (ITS) by Zhou, Bin, Sherry Liu, X, Wang, Ji, Lucas Lu, X, Fields, Aaron J, Edward Guo, X

“…Abstract Individual trabecula segmentation (ITS) technique can decompose the trabecular bone network into individual trabecular plates and rods and is capable…”
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miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2 by Wei, Jianwen, Shi, Yu, Zheng, Lihua, Zhou, Bin, Inose, Hiroyuki, Wang, Ji, Guo, X Edward, Grosschedl, Rudolf, Karsenty, Gerard

“…A screen of microRNAs preferentially expressed in osteoblasts identified members of the miR-34 family as regulators of osteoblast proliferation and/or…”
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Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis by Chen, Yan, Hu, Yizhong, Yu, Y Eric, Zhang, Xingjian, Watts, Tezita, Zhou, Bin, Wang, Ji, Wang, Ting, Zhao, Weiwei, Chiu, Kwong Yuen, Leung, Frankie KL, Cao, Xu, Macaulay, William, Nishiyama, Kyle K, Shane, Elizabeth, Lu, William W, Guo, X Edward

“…ABSTRACT Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has remained a challenge, primarily because of limited…”
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Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect by Ortuño, María José, Robinson, Samuel T, Subramanyam, Prakash, Paone, Riccardo, Huang, Yung-yu, Guo, X Edward, Colecraft, Henry M, Mann, J John, Ducy, Patricia

“…Long-term use of serotonin-reuptake inhibitors causes bone loss by acting centrally to counteract a peripheral, beneficial effect on bone. The use of selective…”
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Bariatric Surgery Results in Cortical Bone Loss by Stein, Emily M, Carrelli, Angela, Young, Polly, Bucovsky, Mariana, Zhang, Chiyuan, Schrope, Beth, Bessler, Marc, Zhou, Bin, Wang, Ji, Guo, X. Edward, McMahon, Donald J, Silverberg, Shonni J

“…Background: Bariatric surgery results in bone loss at weight-bearing sites, the mechanism of which is unknown. Methods: Twenty-two women (mean body mass index…”
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A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice by Luo, Na, Mosialou, Ioanna, Capulli, Mattia, Bisikirska, Brygida, Lin, Chyuan-Sheng, Huang, Yung-Yu, Shyu, Peter T, Guo, X Edward, Economides, Aris, Mann, J John, Kousteni, Stavroula

“…The various functions of the skeleton are influenced by extracellular cues, hormones, and neurotransmitters. One type of neuronal regulation favors bone mass…”
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Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone by Wang, Ji, Zhou, Bin, Liu, X. Sherry, Fields, Aaron J, Sanyal, Arnav, Shi, Xiutao, Adams, Mark, Keaveny, Tony M, Guo, X. Edward

“…Abstract The microstructure of trabecular bone is usually perceived as a collection of plate-like and rod-like trabeculae, which can be determined from the…”
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Commonality in the microarchitecture of trabecular bone: A preliminary study by Zhao, Feng, Kirby, Matthew, Roy, Anuradha, Hu, Yizhong, Guo, X. Edward, Wang, Xiaodu

“…Understanding the relationship between the microstructure and mechanical function of trabecular bone is critical for prediction and prevention of bone…”
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Optimizing the medium perfusion rate in bone tissue engineering bioreactors by Grayson, Warren L., Marolt, Darja, Bhumiratana, Sarindr, Fröhlich, Mirjam, Guo, X. Edward, Vunjak-Novakovic, Gordana

“…There is a critical need to increase the size of bone grafts that can be cultured in vitro for use in regenerative medicine. Perfusion bioreactors have been…”
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Engineering anatomically shaped human bone grafts by Grayson, Warren L, Fröhlich, Mirjam, Yeager, Keith, Bhumiratana, Sarindr, Chan, M. Ete, Cannizzaro, Christopher, Wan, Leo Q, Liu, X. Sherry, Guo, X. Edward, Vunjak-Novakovic, Gordana

“…The ability to engineer anatomically correct pieces of viable and functional human bone would have tremendous potential for bone reconstructions after…”
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Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics by Liu, Xiyu, Yan, Zedong, Cai, Jing, Wang, Dan, Yang, Yongqing, Ding, Yuanjun, Shao, Xi, Hao, Xiaoxia, Luo, Erping, Guo, X Edward, Luo, Peng, Shen, Liangliang, Jing, Da

“…Disuse osteoporosis is a metabolic bone disease resulting from skeletal unloading (e.g., during extended bed rest, limb immobilization, and spaceflight), and…”
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Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow by Lu, X Lucas, Huo, Bo, Chiang, Victor, Guo, X Edward

“…Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular…”
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Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics by Shao, Xi, Tian, Yulan, Liu, Juan, Yan, Zedong, Ding, Yuanjun, Hao, Xiaoxia, Wang, Dan, Shen, Liangliang, Luo, Erping, Guo, X. Edward, Luo, Peng, Luo, Wenjing, Cai, Jing, Jing, Da

“…Type 2 diabetes (T2D)-related fragility fractures represent an increasingly tough medical challenge, and the current treatment options are limited. Mechanical…”
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Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis by Fu, Wenyu, Vasylyev, Dmytro, Bi, Yufei, Zhang, Mingshuang, Sun, Guodong, Khleborodova, Asya, Huang, Guiwu, Zhao, Libo, Zhou, Renpeng, Li, Yonggang, Liu, Shujun, Cai, Xianyi, He, Wenjun, Cui, Min, Zhao, Xiangli, Hettinghouse, Aubryanna, Good, Julia, Kim, Ellen, Strauss, Eric, Leucht, Philipp, Schwarzkopf, Ran, Guo, Edward X., Samuels, Jonathan, Hu, Wenhuo, Attur, Mukundan, Waxman, Stephen G., Liu, Chuan-ju

“…Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain 1…”
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A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure by Yadav, Vijay K., Oury, Franck, Suda, Nina, Liu, Zhong-Wu, Gao, Xiao-Bing, Confavreux, Cyrille, Klemenhagen, Kristen C., Tanaka, Kenji F., Gingrich, Jay A., Guo, X. Edward, Tecott, Laurence H., Mann, J. John, Hen, Rene, Horvath, Tamas L., Karsenty, Gerard

“…Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on these neurons. The same is…”
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Abdominal Fat Is Associated With Lower Bone Formation and Inferior Bone Quality in Healthy Premenopausal Women: A Transiliac Bone Biopsy Study by Cohen, Adi, Dempster, David W, Recker, Robert R, Lappe, Joan M, Zhou, Hua, Zwahlen, Alexander, Müller, Ralph, Zhao, Binsheng, Guo, Xiaotao, Lang, Thomas, Saeed, Isra, Liu, X. Sherry, Guo, X. Edward, Cremers, Serge, Rosen, Clifford J, Stein, Emily M, Nickolas, Thomas L, McMahon, Donald J, Young, Polly, Shane, Elizabeth

“…Context: The conventional view that obesity is beneficial for bone strength has recently been challenged by studies that link obesity, particularly visceral…”
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The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: Involvement of osteoprotegerin by Peng, Songlin, Liu, X. Sherry, Huang, Shishu, Li, Zhaoyang, Pan, Haobo, Zhen, Wanxin, Luk, K.D.K, Guo, X. Edward, Lu, W. William

“…Abstract Background The mechanism for the uncoupling effects of Sr on bone remains to be evaluated. Osteoblasts play important roles in osteoclastogenesis…”
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