Search Results - "Guo, Wenting"

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2 by Peng, Wei, Shen, Huaizong, Wu, Jianping, Guo, Wenting, Pan, Xiaojing, Wang, Ruiwu, Chen, S. R. Wayne, Yan, Nieng

“…RyR2 is a high-conductance intracellular calcium (Ca ) channel that controls the release of Ca from the sarco(endo)plasmic reticulum of a variety of cells…”
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Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis by Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Vandoorne, Tijs, Eckelmann, Bradley J., Mitra, Sankar, Tomkinson, Alan E., Van Den Bosch, Ludo, Hegde, Muralidhar L.

“…Genome damage and defective repair are etiologically linked to neurodegeneration. However, the specific mechanisms involved remain enigmatic. Here, we identify…”
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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients by Guo, Wenting, Naujock, Maximilian, Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Boon, Ruben, Ordovás, Laura, Patel, Abdulsamie, Welters, Marc, Vanwelden, Thomas, Geens, Natasja, Tricot, Tine, Benoy, Veronick, Steyaert, Jolien, Lefebvre-Omar, Cynthia, Boesmans, Werend, Jarpe, Matthew, Sterneckert, Jared, Wegner, Florian, Petri, Susanne, Bohl, Delphine, Vanden Berghe, Pieter, Robberecht, Wim, Van Damme, Philip, Verfaillie, Catherine, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in…”
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The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications by Guo, Wenting, Vandoorne, Tijs, Steyaert, Jolien, Staats, Kim A, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive…”
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Prototype for 5G New Air Interface Technology SCMA and Performance Evaluation by Lu, Lei, Chen, Yan, Guo, Wenting, Yang, Huilian, Wu, Yiqun, Xing, Shuangshuang

“…Sparse code multiple access(SCMA) is a novel non-orthogonal multiple access scheme proposed to meet the challenging demand of the future 5G communications,…”
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Effects of Heterogeneous Particle Parameters on Micro-EHL Lubrication on Composite Surface in Line Contact by Chen, Juan, Chen, Keying, Zeng, Liangcai, Guo, Wenting

“…In this paper, a numerical model of elastohydrodynamic lubrication (EHL) in the line contact which happens on the surface of particle-reinforced composites is…”
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Current Advances and Limitations in Modeling ALS/FTD in a Dish Using Induced Pluripotent Stem Cells by Guo, Wenting, Fumagalli, Laura, Prior, Robert, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two age-dependent multifactorial neurodegenerative disorders, which are typically…”
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Vacuum sealing drainage system combined with an antibacterial jackfruit aerogel wound dressing and 3D printed fixation device for infections of skin soft tissue injuries by Hu, Xin, Li, Huijian, Guo, Wenting, Xiang, Huiqin, Hao, Liang, Ai, Fanrong, Sahu, Souradeep, Li, Chen

“…Injuries and infections of skin and soft tissue are commonly encountered in primary health care and are challenging to manage. Vacuum sealing drainage (VSD) is…”
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Cardiac ryanodine receptor calcium release deficiency syndrome by Sun, Bo, Yao, Jinjing, Ni, Mingke, Wei, Jinhong, Zhong, Xiaowei, Guo, Wenting, Zhang, Lin, Wang, Ruiwu, Belke, Darrell, Chen, Yong-Xiang, Lieve, Krystien V V, Broendberg, Anders K, Roston, Thomas M, Blankoff, Ivan, Kammeraad, Janneke A, von Alvensleben, Johannes C, Lazarte, Julieta, Vallmitjana, Alexander, Bohne, Loryn J, Rose, Robert A, Benitez, Raul, Hove-Madsen, Leif, Napolitano, Carlo, Hegele, Robert A, Fill, Michael, Sanatani, Shubhayan, Wilde, Arthur A M, Roberts, Jason D, Priori, Silvia G, Jensen, Henrik K, Chen, S R Wayne

“…Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by…”
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Boron nitride quantum dots loading red phosphorus for efficient visible-light-driven photocatalytic degradation of organic pollutants by Guo, Wenting, Yang, Yuanyuan, Jin, Qianwei, Zhao, Hao, Zhang, Ruiqin, Zhai, Yunpu, Liu, Yonggang

“…Constructing new metal-free green materials opens up new research directions for photocatalysis. Red phosphorus (RP) modified by boron nitride quantum dots…”
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Editorial: RNA metabolism and DNA stability in the central nervous system (CNS): from aging to neurodegenerative disease by Li, Tangliang, Guo, Wenting, Wang, Haibo

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Differentiation but not ALS mutations in FUS rewires motor neuron metabolism by Vandoorne, Tijs, Veys, Koen, Guo, Wenting, Sicart, Adria, Vints, Katlijn, Swijsen, Ann, Moisse, Matthieu, Eelen, Guy, Gounko, Natalia V., Fumagalli, Laura, Fazal, Raheem, Germeys, Christine, Quaegebeur, Annelies, Fendt, Sarah-Maria, Carmeliet, Peter, Verfaillie, Catherine, Van Damme, Philip, Ghesquière, Bart, De Bock, Katrien, Van Den Bosch, Ludo

“…Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown…”
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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation by Yao, Jinjing, Sun, Bo, Institoris, Adam, Zhan, Xiaoqin, Guo, Wenting, Song, Zhenpeng, Liu, Yajing, Hiess, Florian, Boyce, Andrew K.J., Ni, Mingke, Wang, Ruiwu, ter Keurs, Henk, Back, Thomas G., Fill, Michael, Thompson, Roger J., Turner, Ray W., Gordon, Grant R., Chen, S.R. Wayne

“…Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed…”
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FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease by Kodavati, Manohar, Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Provasek, Vincent, Rao, Vikas H. Maloji, Vedula, Indira, Zhang, Aijun, Mitra, Sankar, Tomkinson, Alan E., Hamilton, Dale J., Van Den Bosch, Ludo, Hegde, Muralidhar L.

“…This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis…”
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Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK by Li, Xiaojia, Li, Kangjie, Guo, Wenting, Wen, Yan, Meng, Chunyan, Wu, Baixing

“…Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic…”
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Total White Blood Cell Count Mediated the Association Between Increased Arterial Stiffness and Risk of Type 2 Diabetes Mellitus in Chinese Adults by Liu, Yongming, Lai, Xuefeng, Guo, Wenting, Ma, Lin, Li, Wenze, Fang, Qin, Yang, Huihua, Cai, Yunyao, Liu, Miao, Zhang, Xiaomin, Yang, Liangle

“…Type 2 diabetes mellitus (T2DM) is known to be related to increased arterial stiffness. However, little is known about the risk of T2DM due to accelerated…”
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Short term effects of air pollutants on hospital admissions for respiratory diseases among children: A multi-city time-series study in China by Yang, Huihua, Yan, Chunxiang, Li, Meng, Zhao, Lei, Long, Zhen, Fan, Yali, Zhang, Zhonggang, Chen, Renjie, Huang, Yihui, Lu, Congbin, Zhang, Jianduan, Tang, Jie, Liu, Hua, Liu, Miao, Guo, Wenting, Yang, Liangle, Zhang, Xiaomin

“…Evidence concerning short-term acute association between air pollutants and hospital admissions for respiratory diseases among children in a multi-city setting…”
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Selective Chemical Labeling and Sequencing of 5-Hydroxymethylcytosine in DNA at Single-Base Resolution by Li, Xiaogang, Shi, Xinxin, Gong, Yin, Guo, Wenting, Liu, Yuanrui, Peng, Chunwei, Xu, Yingchun

“…5-Hydroxymethylcytosine (5hmC), the oxidative product of 5-methylcytosine (5mC) catalyzed by ten-eleven translocation enzymes, plays an important role in many…”
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Dynamic changes in soil moisture in three typical landscapes of the Heihe River Basin by Gou, Qianqian, Guo, Wenting, Li, Yuda, Liu, Jing, Wang, Guohua

“…The water diversion scheme of Heihe River Basin was implemented in 2000. Herein, we investigated the dynamic changes in soil moisture content and analyzed the…”
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Association of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with outcomes in stroke patients achieving successful recanalization by endovascular thrombectomy by Ma, Jin, Guo, Wenting, Xu, Jiali, Li, Sijie, Ren, Changhong, Wu, Longfei, Wu, Chuanjie, Li, Chuanhui, Chen, Jian, Duan, Jiangang, Ma, Qingfeng, Song, Haiqing, Zhao, Wenbo, Ji, Xunming

“…Serum inflammatory biomarkers play crucial roles in the development of acute ischemic stroke (AIS). In this study, we explored the association between…”
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