Search Results - "Guo, Shuchi"

Cardiac GPCR-mediated EGFR transactivation: impact and therapeutic implications by Grisanti, Laurel A, Guo, Shuchi, Tilley, Douglas G

“…ABSTRACTG protein-coupled receptors (GPCR) remain primary therapeutic targets for numerous cardiovascular disorders, including heart failure (HF), due to their…”
Get full text

REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids by Baida, Gleb, Bhalla, Pankaj, Kirsanov, Kirill, Lesovaya, Ekaterina, Yakubovskaya, Marianna, Yuen, Kit, Guo, Shuchi, Lavker, Robert M, Readhead, Ben, Dudley, Joel T, Budunova, Irina

“…Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify…”
Get full text

Impact of Paroxetine on Proximal β‐adrenergic Receptor Signaling by Guo, Shuchi, Carter, Rhonda, Tilley, Douglas

“…Abstract only β‐adrenergic receptor (βAR) signaling normally relays sympathetic signals to the heart, but during the development of heart failure, aberrant βAR…”
Get full text

Resident cardiac macrophages mediate adaptive myocardial remodeling by Wong, Nicole R., Mohan, Jay, Kopecky, Benjamin J., Guo, Shuchi, Du, Lixia, Leid, Jamison, Feng, Guoshuai, Lokshina, Inessa, Dmytrenko, Oleksandr, Luehmann, Hannah, Bajpai, Geetika, Ewald, Laura, Bell, Lauren, Patel, Nikhil, Bredemeyer, Andrea, Weinheimer, Carla J., Nigro, Jessica M., Kovacs, Attila, Morimoto, Sachio, Bayguinov, Peter O., Fisher, Max.R., Stump, W. Tom, Greenberg, Michael, Fitzpatrick, James A.J., Epelman, Slava, Kreisel, Daniel, Sah, Rajan, Liu, Yongjian, Hu, Hongzhen, Lavine, Kory J.

“…Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine…”
Get full text

Development of a System for Realtime Assessment of β1‐Adrenergic Receptor Association with Epidermal Growth Factor Receptor by Guo, Shuchi, Carter, Rhonda, Tilley, Douglas

“…Abstract only β‐adrenergic receptors (βAR) are G‐protein coupled receptors (GPCR) highly expressed in the heart and essential for coordinating responses to…”
Get full text

Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons by Hernandez, Luiselys M., Montersino, Audrey, Niu, Jingwen, Guo, Shuchi, Faezov, Bulat, Sanders, Shaun S., Dunbrack, Roland L., Thomas, Gareth M.

“…Janus Kinase-1 (JAK1) plays key roles during neurodevelopment and following neuronal injury, while activatory JAK1 mutations are linked to leukemia. In mice,…”
Get full text

Chemokine Receptor 2-targeted Molecular Imaging in Pulmonary Fibrosis. A Clinical Trial by Brody, Steven L, Gunsten, Sean P, Luehmann, Hannah P, Sultan, Debbie H, Hoelscher, Michelle, Heo, Gyu Seong, Pan, Jiehong, Koenitzer, Jeffrey R, Lee, Ethan C, Huang, Tao, Mpoy, Cedric, Guo, Shuchi, Laforest, Richard, Salter, Amber, Russell, Tonya D, Shifren, Adrian, Combadiere, Christophe, Lavine, Kory J, Kreisel, Daniel, Humphreys, Benjamin D, Rogers, Buck E, Gierada, David S, Byers, Derek E, Gropler, Robert J, Chen, Delphine L, Atkinson, Jeffrey J, Liu, Yongjian

“…Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease without effective molecular markers of disease activity or treatment responses…”
Get full text

Cardiomyocyte‐Specific EGFR Deletion Differentially Alters Cardiac Contractility and Remodeling by Guo, Shuchi, Song, Jianliang, Carter, Rhonda, Lucchese, Ana Maria, Gao, Erhe, Cheung, Joseph, Tilley, Douglas

“…Epidermal Growth Factor Receptor (EGFR), a member of the Erbb receptor tyrosine kinase family, is essential to the development of multiple tissues and organs…”
Get full text

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death by Hoffman, Nicholas E, Chandramoorthy, Harish C, Shanmughapriya, Santhanam, Zhang, Xueqian Q, Vallem, Sandhya, Doonan, Patrick J, Malliankaraman, Karthik, Guo, Shuchi, Rajan, Sudarsan, Elrod, John W, Koch, Walter J, Cheung, Joseph Y, Madesh, Muniswamy

“…Emerging findings suggest that two lineages of mitochondrial Ca(2+) uptake participate during active and resting states: 1) the major eukaryotic membrane…”
Get full text

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU by Shanmughapriya, Santhanam, Rajan, Sudarsan, Hoffman, Nicholas E, Zhang, Xueqian, Guo, Shuchi, Kolesar, Jill E, Hines, Kevin J, Ragheb, Jonathan, Jog, Neelakshi R, Caricchio, Roberto, Baba, Yoshihiro, Zhou, Yandong, Kaufman, Brett A, Cheung, Joseph Y, Kurosaki, Tomohiro, Gill, Donald L, Madesh, Muniswamy

“…Cytosolic Ca2+ signals, generated through the coordinated translocation of Ca2+ across the plasma membrane (PM) and endoplasmic reticulum (ER) membrane,…”
Get more information

Epidermal growth factor receptor association with β1-adrenergic receptor is mediated via its juxtamembrane domain by Patwa, Viren, Guo, Shuchi, Carter, Rhonda L., Kraus, Lindsay, Einspahr, Jeanette, Teplitsky, David, Sabri, Abdelkarim, Tilley, Douglas G.

“…β1-adrenergic receptor (β1AR)-mediated transactivation of epidermal growth factor receptor (EGFR) engages downstream signaling events that impact numerous…”
Get full text

Epidermal growth factor receptor-dependent maintenance of cardiac contractility by Guo, Shuchi, Okyere, Ama Dedo, McEachern, Erin, Strong, Joshua L, Carter, Rhonda L, Patwa, Viren C, Thomas, Toby P, Landy, Melissa, Song, Jianliang, Lucchese, Ana Maria, Martin, Thomas G, Gao, Erhe, Rajan, Sudarsan, Kirk, Jonathan A, Koch, Walter J, Cheung, Joseph Y, Tilley, Douglas G

“…Abstract Aims Epidermal growth factor receptor (EGFR) is essential to the development of multiple tissues and organs and is a target of cancer therapeutics…”
Get full text

Abstract 423: Cardiomyocyte-Specific Epidermal Growth Factor Receptor Deletion Differentially Alters Cardiac Contractility and Remodeling During Physiologic versus Pathologic Development by Guo, Shuchi, Lambert, Jonathan, Song, Jianliang, Carter, Rhonda, Lucchese, Ana Maria, Gao, Erhe, Cheung, Joseph, Elrod, John, Tilley, Douglas

“…Abstract only Epidermal Growth Factor Receptor (EGFR), a member of the Erbb receptor tyrosine kinase family, is essential to the development of multiple tissue…”
Get full text

Impact of paroxetine on proximal β-adrenergic receptor signaling by Guo, Shuchi, Carter, Rhonda L., Grisanti, Laurel A., Koch, Walter J., Tilley, Douglas G.

“…β-adrenergic receptors (βAR) regulate numerous functions throughout the body, however G protein-coupled receptor kinase (GRK)-dependent desensitization of βAR…”
Get full text

Epidermal Growth Factor Receptor - an Essential Mediator of Cardiac Contractile Function and Remodeling by Guo, Shuchi

“…Epidermal Growth Factor Receptor (EGFR), a member of the Erbb receptor tyrosine kinase family, is essential to the development of multiple tissue and organs…”
Get full text

SLC25A23 augments mitochondrial Ca 2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death by Hoffman, Nicholas E., Chandramoorthy, Harish C., Shanmughapriya, Santhanam, Zhang, Xueqian Q., Vallem, Sandhya, Doonan, Patrick J., Malliankaraman, Karthik, Guo, Shuchi, Rajan, Sudarsan, Elrod, John W., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy

“…Emerging findings suggest that two lineages of mitochondrial Ca 2+ uptake participate during active and resting states: 1) the major eukaryotic membrane…”
Get full text

REDD 1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids by Baida, Gleb, Bhalla, Pankaj, Kirsanov, Kirill, Lesovaya, Ekaterina, Yakubovskaya, Marianna, Yuen, Kit, Guo, Shuchi, Lavker, Robert M, Readhead, Ben, Dudley, Joel T, Budunova, Irina

“…Abstract Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify…”
Get full text