Search Results - "Guo, Qianni"
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Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution
Published in Proceedings of the National Academy of Sciences - PNAS (28-07-2020)“…We report hyperpolarized Xe signal advancement by metal-organic framework (MOF) entrapment (Hyper-SAME) in aqueous solution. The 129Xe NMR signal is…”
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Protocol for detecting substrates in living cells by targeted molecular probes through hyperpolarized 129Xe MRI
Published in STAR protocols (16-09-2022)“…Due to limited detection sensitivity and contrast limitation, imaging substrates with 129Xe MRI in living cells is still a challenge. Here, we present an…”
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Ultrasensitive molecular building block for biothiol NMR detection at picomolar concentrations
Published in iScience (17-12-2021)“…Magnetic resonance imaging (MRI) provides structural and functional information, but it did not probe chemistry. Chemical information could help improve…”
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Hyperpolarized 129Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging
Published in Analytical chemistry (Washington) (25-06-2024)“…Assessing the effectiveness of nanomedicines involves evaluating the drug content at the target site. Currently, most research focuses on monitoring the signal…”
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Hyperpolarized 129 Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging
Published in Analytical chemistry (Washington) (25-06-2024)“…Assessing the effectiveness of nanomedicines involves evaluating the drug content at the target site. Currently, most research focuses on monitoring the signal…”
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Molecular Concentration Determination Using Long-Interval Chemical Exchange Inversion Transfer (CEIT) NMR Spectroscopy
Published in The journal of physical chemistry letters (09-09-2021)“…Functionalized hyperpolarized xenon “cage” molecules have often been used for ultrasensitive detection of biomolecules and microenvironment properties…”
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Pitaya-Inspired Metal-Organic Framework Nanozyme for Multimodal Imaging-Guided Synergistic Cuproptosis, Nanocatalytic Therapy, and Photothermal Therapy
Published in Advanced healthcare materials (23-10-2024)“…Nature often provides invaluable insights into technological innovation and the construction of nanomaterials. Inspired by the pitaya fruit's strategy of…”
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Dual-Signal Chemical Exchange Saturation Transfer (Dusi-CEST): An Efficient Strategy for Visualizing Drug Delivery Monitoring in Living Cells
Published in Analytical chemistry (Washington) (30-01-2024)“…We report a dual-signal chemical exchange saturation transfer (Dusi-CEST) strategy for drug delivery and detection in living cells. The two signals can be…”
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Coloring ultrasensitive MRI with tunable metal-organic frameworks
Published in Chemical science (Cambridge) (01-04-2021)“…As one of the most important imaging modalities, magnetic resonance imaging (MRI) still faces relatively low sensitivity to monitor low-abundance molecules. A…”
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Photosensitive MRI biosensor for BCRP-Targeted uptake and light-induced inhibition of tumor cells
Published in Talanta (Oxford) (01-10-2021)“…Riboflavin and its derivatives are the most important coenzymes in vivo metabolism, and are closely related to life activities. In this paper, the first…”
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Free‐base porphyrins as CEST MRI contrast agents with highly upfield shifted labile protons
Published in Magnetic resonance in medicine (01-08-2019)“…Purpose CEST has become a preeminent technology for the rapid detection and grading of tumors, securing its widespread use in both laboratory and clinical…”
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Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction
Published in Analytical chemistry (Washington) (07-06-2016)“…Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play an important role in regulating the vital functions of living organisms…”
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A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized (129)Xe Molecular Clamp Probe
Published in Chemistry : a European journal (14-03-2016)“…Mercury pollution, in the form of mercury ions (Hg(2+)), is a major health and environmental hazard. Commonly used sensors are invasive and limited to point…”
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Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions
Published in Talanta (Oxford) (01-05-2014)“…Although Zn2+ ions are involved in large numbers of physiopathological processes, non-invasive detection of Zn2+ ions in opaque biological samples remains a…”
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Detection and differentiation of Cys, Hcy and GSH mixtures by 19F NMR probe
Published in Talanta (Oxford) (01-07-2018)“…Simultaneous detection and differentiation of biomolecules is of significance in biological research. Biothiols such as cysteine (Cys), homocysteine (Hcy), and…”
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An intracellular diamine oxidase triggered hyperpolarized 129 Xe magnetic resonance biosensor
Published in Chemical communications (Cambridge, England) (04-12-2018)“…Here, a novel method was developed for suppressing 129Xe signals in cucurbit[6]uril (CB6) until the trigger is activated by a specific enzyme. Due to its…”
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Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI
Published in Journal of materials chemistry. B, Materials for biology and medicine (21-06-2020)“…MRI with hyperpolarized Xe can achieve low-concentration detection. Herein, nanoparticle-coated perfluorooctyl bromide (PFOB) was developed as a Xe MRI…”
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A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129 Xe Molecular Clamp Probe
Published in Chemistry : a European journal (14-03-2016)“…Mercury pollution, in the form of mercury ions (Hg 2+ ), is a major health and environmental hazard. Commonly used sensors are invasive and limited to point…”
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A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized super(129)Xe Molecular Clamp Probe
Published in Chemistry : a European journal (01-03-2016)“…Mercury pollution, in the form of mercury ions (Hg super(2+)), is a major health and environmental hazard. Commonly used sensors are invasive and limited to…”
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Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized 129Xe Magnetofluorescent Biosensor
Published in Analytical chemistry (Washington) (21-02-2017)“…Biothiols such as gluthathione (GSH), cysteine (Cys), homocysteine (Hcy), and thioredoxin (Trx) play vital roles in cellular metabolism. Various diseases are…”
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