Search Results - "Guo, Monica S"
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1
Evolutionary Convergence of Pathway-Specific Enzyme Expression Stoichiometry
Published in Cell (19-04-2018)“…Coexpression of proteins in response to pathway-inducing signals is the founding paradigm of gene regulation. However, it remains unexplored whether the…”
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2
Stress-Induced Remodeling of the Bacterial Proteome
Published in Current biology (19-05-2014)“…Microorganisms live in fluctuating environments, requiring stress response pathways to resist environmental insults and stress. These pathways dynamically…”
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3
Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress
Published in Science (American Association for the Advancement of Science) (17-05-2013)“…In Gram-negative bacteria, outer-membrane integrity is essential for survival and is monitored by the σ Ε stress-response system, which initiates damage-repair…”
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4
High-resolution, genome-wide mapping of positive supercoiling in chromosomes
Published in eLife (19-07-2021)“…Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-dimensional organization of chromosomes. However, there are…”
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5
Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library
Published in eLife (27-10-2020)“…Protein-protein interaction specificity is often encoded at the primary sequence level. However, the contributions of individual residues to specificity are…”
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6
Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins
Published in eLife (21-03-2017)“…Most bacteria are in fierce competition with other species for limited nutrients. Some bacteria can kill nearby cells by secreting bacteriocins, a diverse…”
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7
Regulators of rDNA array morphology in fission yeast
Published in PLoS genetics (05-07-2024)“…Nucleolar morphology is a well-established indicator of ribosome biogenesis activity that has served as the foundation of many screens investigating ribosome…”
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8
Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses
Published in PLoS pathogens (13-09-2023)“…Viruses hijack host proteins to promote infection and dampen host defenses. Adenovirus encodes the multifunctional protein VII that serves both to compact…”
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9
A CRISPR Interference System for Efficient and Rapid Gene Knockdown in Caulobacter crescentus
Published in mBio (14-01-2020)“…CRISPR interference (CRISPRi) is a powerful new tool used in different organisms that provides a fast, specific, and reliable way to knock down gene…”
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10
Differential roles of positive and negative supercoiling in organizing the E. coli genome
Published in Nucleic acids research (25-01-2024)“…Abstract This study aims to explore whether and how positive and negative supercoiling contribute to the three-dimensional (3D) organization of the bacterial…”
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11
A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication
Published in Cell (04-10-2018)“…When DNA is unwound during replication, it becomes overtwisted and forms positive supercoils in front of the translocating DNA polymerase. Unless removed or…”
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12
Signal integration by DegS and RseB governs the σE-mediated envelope stress response in Escherichia coli
Published in Proceedings of the National Academy of Sciences - PNAS (01-02-2011)“…In Escherichia coli, the σE transcription factor monitors and maintains outer membrane (OM) integrity by activating genes required for assembly of its two key…”
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13
MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein
Published in Genes & development (15-07-2014)“…In enteric bacteria, the transcription factor σ(E) maintains membrane homeostasis by inducing synthesis of proteins involved in membrane repair and two small…”
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14
Temporospatial control of topoisomerases by essential cellular processes
Published in Current opinion in microbiology (01-12-2024)“…Topoisomerases are essential, ubiquitous enzymes that break and rejoin the DNA strand to control supercoiling. Because topoisomerases are DNA scissors, these…”
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15
MicL, a new [sigma] super(E)-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein
Published in Genes & development (15-07-2014)“…In enteric bacteria, the transcription factor [sigma] super(E) maintains membrane homeostasis by inducing synthesis of proteins involved in membrane repair and…”
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Journal Article -
16
Signal integration by DegS and RseB governs the [sigma]E-mediated envelope stress response in Escherichia coli
Published in Proceedings of the National Academy of Sciences - PNAS (01-02-2011)“…In Escherichia coli, the ... transcription factor monitors and maintains outer membrane (OM) integrity by activating genes required for assembly of its two key…”
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Journal Article -
17
Signal integration by DegS and RseB governs the ÏE-mediated envelope stress response in Escherichia coli
Published in Proceedings of the National Academy of Sciences - PNAS (2011)“…In Escherichia coli, the ÏE transcription factor monitors and maintains outer membrane (OM) integrity by activating genes required for assembly of its two key…”
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Journal Article -
18
Regulation of Bacterial Outer Membrane Homeostasis by the σ-factor, σE
Published 01-01-2014“…The outer membrane (OM) is the first line of defense for Gram-negative bacteria against the exterior environment, as it forms an impermeable lipid barrier to…”
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Dissertation