Search Results - "Guo, Margaret"

Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics by Longo, Sophia K., Guo, Margaret G., Ji, Andrew L., Khavari, Paul A.

“…Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but does not capture their spatial distribution nor reveal local networks…”
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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma by Ji, Andrew L., Rubin, Adam J., Thrane, Kim, Jiang, Sizun, Reynolds, David L., Meyers, Robin M., Guo, Margaret G., George, Benson M., Mollbrink, Annelie, Bergenstråhle, Joseph, Larsson, Ludvig, Bai, Yunhao, Zhu, Bokai, Bhaduri, Aparna, Meyers, Jordan M., Rovira-Clavé, Xavier, Hollmig, S. Tyler, Aasi, Sumaira Z., Nolan, Garry P., Lundeberg, Joakim, Khavari, Paul A.

“…To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial…”
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The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation by Meyers, Jordan M, Ramanathan, Muthukumar, Shanderson, Ronald L, Beck, Aimee, Donohue, Laura, Ferguson, Ian, Guo, Margaret G, Rao, Deepti S, Miao, Weili, Reynolds, David, Yang, Xue, Zhao, Yang, Yang, Yen-Yu, Blish, Catherine, Wang, Yinsheng, Khavari, Paul A

“…Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas…”
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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma by Ji, Andrew L., Rubin, Adam J., Thrane, Kim, Jiang, Sizun, Reynolds, David L., Meyers, Robin M., Guo, Margaret G., George, Benson M., Mollbrink, Annelie, Bergenstråhle, Joseph, Larsson, Ludvig, Bai, Yunhao, Zhu, Bokai, Bhaduri, Aparna, Meyers, Jordan M., Rovira-Clavé, Xavier, Hollmig, S. Tyler, Aasi, Sumaira Z., Nolan, Garry P., Lundeberg, Joakim, Khavari, Paul A.

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Challenges and opportunities in network-based solutions for biological questions by Guo, Margaret G, Sosa, Daniel N, Altman, Russ B

“…Abstract Network biology is useful for modeling complex biological phenomena; it has attracted attention with the advent of novel graph-based machine learning…”
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Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic Cells by Thrane, Kim, Winge, Mårten C.G., Wang, Hongyu, Chen, Larry, Guo, Margaret G., Andersson, Alma, Abalo, Xesús M., Yang, Xue, Kim, Daniel S., Longo, Sophia K., Soong, Brian Y., Meyers, Jordan M., Reynolds, David L., McGeever, Aaron, Demircioglu, Deniz, Hasson, Dan, Mirzazadeh, Reza, Rubin, Adam J., Bae, Gordon H., Karkanias, Jim, Rieger, Kerri, Lundeberg, Joakim, Ji, Andrew L.

“…Epidermal homeostasis is governed by a balance between keratinocyte proliferation and differentiation with contributions from cell–cell interactions, but…”
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Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases by Guo, Margaret G., Reynolds, David L., Ang, Cheen E., Liu, Yingfei, Zhao, Yang, Donohue, Laura K. H., Siprashvili, Zurab, Yang, Xue, Yoo, Yongjin, Mondal, Smarajit, Hong, Audrey, Kain, Jessica, Meservey, Lindsey, Fabo, Tania, Elfaki, Ibtihal, Kellman, Laura N., Abell, Nathan S., Pershad, Yash, Bayat, Vafa, Etminani, Payam, Holodniy, Mark, Geschwind, Daniel H., Montgomery, Stephen B., Duncan, Laramie E., Urban, Alexander E., Altman, Russ B., Wernig, Marius, Khavari, Paul A.

“…Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to…”
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A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation by Donohue, Laura K.H., Guo, Margaret G., Zhao, Yang, Jung, Namyoung, Bussat, Rose T., Kim, Daniel S., Neela, Poornima H., Kellman, Laura N., Garcia, Omar S., Meyers, Robin M., Altman, Russ B., Khavari, Paul A.

“…Gene expression is controlled by transcription factors (TFs) that bind cognate DNA motif sequences in cis-regulatory elements (CREs). The combinations of DNA…”
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A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare Diseases by Sosa, Daniel N, Derry, Alexander, Guo, Margaret, Wei, Eric, Brinton, Connor, Altman, Russ B

“…Millions of Americans are affected by rare diseases, many of which have poor survival rates. However, the small market size of individual rare diseases,…”
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Pathway and network embedding methods for prioritizing psychiatric drugs by Pershad, Yash, Guo, Margaret, Altman, Russ B

“…One in five Americans experience mental illness, and roughly 75% of psychiatric prescriptions do not successfully treat the patient's condition. Extensive…”
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Clustering of capnogram features to track state transitions during procedural sedation by Mieloszyk, Rebecca J., Guo, Margaret G., Verghese, George C., Andolfatto, Gary, Heldt, Thomas, Krauss, Baruch S.

“…Procedural sedation has allowed many painful interventions to be conducted outside the operating room. During such procedures, it is important to maintain an…”
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PROBER identifies proteins associated with programmable sequence-specific DNA in living cells by Mondal, Smarajit, Ramanathan, Muthukumar, Miao, Weili, Meyers, Robin M., Rao, Deepti, Lopez-Pajares, Vanessa, Siprashvili, Zurab, Reynolds, David L., Porter, Douglas F., Ferguson, Ian, Neela, Poornima, Zhao, Yang, Meservey, Lindsey M., Guo, Margaret, Yang, Yen-Yu, Li, Lin, Wang, Yinsheng, Khavari, Paul A.

“…DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA variants linked to polygenic disease. To enhance the speed and…”
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Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function by Cook, Christi D, Hill, Abby S, Guo, Margaret, Stockdale, Linda, Papps, Julia P, Isaacson, Keith B, Lauffenburger, Douglas A, Griffith, Linda G

“…Mucosal barrier tissues, comprising a layer of tightly-bonded epithelial cells in intimate molecular communication with an underlying matrix-rich stroma…”
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Decoding Transcription Regulatory Patterns in Health and Disease by Guo, Margaret Gan

“…Transcriptional control of gene expression is known to be a cell-type specific process that depends on many different factors: including the underlying DNA…”
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Incorporating an Early Detection System Into Routine Clinical Practice in Two Community Hospitals by Dummett, B. Alex, Adams, Carmen, Scruth, Elizabeth, Liu, Vincent, Guo, Margaret, Escobar, Gabriel J.

“…Efforts to improve outcomes of patients who deteriorate outside the intensive care unit have included the use of rapid response teams (RRTs) as well as manual…”
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Development and initial validation of a novel smoothed‐particle hydrodynamics‐based simulation model of trabecular bone penetration by metallic implants by Kulper, Sloan A., Fang, Christian X., Ren, Xiaodan, Guo, Margaret, Sze, Kam Y., Leung, Frankie K. L., Lu, William W.

“…ABSTRACT A novel computational model of implant migration in trabecular bone was developed using smoothed‐particle hydrodynamics (SPH), and an initial…”
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Assessment of Cell Binding to Hyaluronic Acid in a Solid-Phase Assay by Guo, Margaret M.Lee, Hildreth, James E.K.

“…Adhesion to hyaluronate by tumor cells has been shown to correlate with disease progression in various types of neoplasms. In order to study cell binding to…”
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Automated Detection of Diabetic Retinopathy using Deep Learning by Lam, Carson, Yi, Darvin, Guo, Margaret, Lindsey, Tony

“…Diabetic retinopathy is a leading cause of blindness among working-age adults. Early detection of this condition is critical for good prognosis. In this paper,…”
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A novel fracture mechanics model explaining the axial penetration of bone-like porous, compressible solids by various orthopaedic implant tips by Kulper, Sloan A., Sze, K.Y., Fang, Christian X., Ren, Xiaodan, Guo, Margaret, Schneider, Kerstin, Leung, Frankie, Lu, William, Ngan, Alfonso

“…Many features of orthopaedic implants have been previously examined regarding their influence on migration in trabecular bone under axial loading, with screw…”
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Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological functionElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ib00245e by Cook, Christi D, Hill, Abby S, Guo, Margaret, Stockdale, Linda, Papps, Julia P, Isaacson, Keith B, Lauffenburger, Douglas A, Griffith, Linda G

“…Mucosal barrier tissues, comprising a layer of tightly-bonded epithelial cells in intimate molecular communication with an underlying matrix-rich stroma…”
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