Search Results - "Guo, Lida"

Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731 by Huang, Qi, Cai, Dawei, Yan, Ran, Li, Lichun, Zong, Yuhua, Guo, Lida, Mercier, Alexandre, Zhou, Yi, Tang, Ariel, Henne, Kirk, Colonno, Richard

“…ABI-H0731, a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity in chronic hepatitis B (CHB)…”
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Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis by Zhu, Ling-Ling, Blair, Harry, Cao, Jay, Yuen, Tony, Latif, Rauf, Guo, Lida, Tourkova, Irina L., Li, Jianhua, Davies, Terry F., Sun, Li, Bian, Zhuan, Rosen, Clifford, Zallone, Alberta, New, Maria I., Zaidi, Mone

“…Low estrogen levels undoubtedly underlie menopausal bone thinning. However, rapid and profuse bone loss begins 3 y before the last menstrual period, when serum…”
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Coinfection of Dermacentor silvarum Olenev (Acari: Ixodidae) by Coxiella-Like, Arsenophonus-Like, and Rickettsia-Like Symbionts by Liu, Limeng, Li, Lingxia, Liu, Jiannan, Hu, Yonghong, Liu, Zhao, Guo, Lida, Liu, Jingze

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Novel Death Defying Domain in met entraps the active site of caspase‐3 and blocks apoptosis in hepatocytes by Ma, Jihong, Zou, Chunbin, Guo, Lida, Seneviratne, Danushka S., Tan, Xinping, Kwon, Yong‐Kook, An, Jiyan, Bowser, Robert, DeFrances, Marie C., Zarnegar, Reza

“…Met, the transmembrane tyrosine kinase receptor for hepatocyte growth factor (HGF), is known to function as a potent antiapoptotic mediator in normal and…”
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β-catenin regulates vascular endothelial growth factor expression in colon cancer by EASWARAN, Vijay, LEE, Sang H, RANDAZZO, Filippo, GUNDEL, Robert, WARREN, Robert S, ESCOBEDO, Jaime, AUKERMAN, Sharon L, TAYLOR, Robert N, FANTL, Wendy J, INGE, Landon, LIDA GUO, GOLDBECK, Cheryl, GARRETT, Evelyn, WIESMANN, Marion, GARCIA, Pablo D, FULLER, John H, CHAN, Vivien

“…To evaluate whether beta-catenin signaling has a role in the regulation of angiogenesis in colon cancer, a series of angiogenesis-related gene promoters was…”
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Multiple lines of evidence on the genetic relatedness of the parthenogenetic and bisexual Haemaphysalis longicornis (Acari: Ixodidae) by Chen, Xuejie, Xu, Shiqi, Yu, Zhijun, Guo, Lida, Yang, Shujie, Liu, Limeng, Yang, Xiaolong, Liu, Jingze

“…•There are two reproductive strategies in the hard tick Haemaphysalis longicornis.•The chromosomes ratio of bisexual and parthenogenetic populations is close…”
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Vitamin C Prevents Hypogonadal Bone Loss by Zhu, Ling-Ling, Cao, Jay, Sun, Merry, Yuen, Tony, Zhou, Raymond, Li, Jianhua, Peng, Yuanzhen, Moonga, Surinder S, Guo, Lida, Mechanick, Jeffrey I, Iqbal, Jameel, Peng, Liu, Blair, Harry C, Bian, Zhuan, Zaidi, Mone, Smith, Brenda

“…Epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise,…”
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Elevated Expression of axin2 and hnkd mRNA Provides Evidence That Wnt/β-Catenin Signaling is Activated in Human Colon Tumors by Yan, Dong, Wiesmann, Marion, Rohan, Michael, Chan, Vivien, Jefferson, Ann B., Guo, Lida, Sakamoto, Doreen, Caothien, Roger H., Fuller, John H., Reinhard, Christoph, Garcia, Pablo D., Randazzo, Filippo M., Escobedo, Jaime, Fantl, Wendy J., Williams, Lewis T.

“…Genetic studies have identified mutations in key regulators of the Wnt/β-catenin pathway in a variety of cancers, most frequently in colon cancers. However,…”
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Regulation of fibronectin matrix deposition and cell proliferation by the PINCH‐ILK‐CH‐ILKBP complex by Guo, Lida, Wu, Chuanyue

“…ABSTRACT Alteration in renal glomerular mesangial cell growth and fibronectin matrix deposition is a hallmark of glomerulosclerosis, which ultimately leads to…”
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Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis by Gkretsi, Vasiliki, Mars, Wendy M., Bowen, William C., Barua, Lindsay, Yang, Yu, Guo, Lida, St.‐Arnaud, René, Dedhar, Shoukat, Wu, Chuanyue, Michalopoulos, George K.

“…Extracellular matrix (ECM) is fundamental for the survival of cells within a tissue. Loss of contact with the surrounding ECM often causes altered cell…”
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Life cycle of Haemaphysalis doenitzi (Acari: Ixodidae) under laboratory conditions and its phylogeny based on mitochondrial 16S rDNA by Chen, Xuejie, Yu, Zhijun, Guo, Lida, Li, Lingxia, Meng, Hao, Wang, Duo, Liu, Renjie, Liu, Jingze

“…The paper investigated the life cycle of the hard tick Haemaphysalis doenitzi under laboratory conditions and its phylogeny based on mitochondrial 16S rDNA…”
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Characterization of PINCH-2, a New Focal Adhesion Protein That Regulates the PINCH-1-ILK Interaction, Cell Spreading, and Migration by Zhang, Yongjun, Chen, Ka, Guo, Lida, Wu, Chuanyue

“…Integrin-linked kinase (ILK) is a multidomain protein that plays important roles at cell-extracellular matrix (ECM) adhesion sites. We describe here a new…”
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A Critical Role of the PINCH-Integrin-linked Kinase Interaction in the Regulation of Cell Shape Change and Migration by Zhang, Yongjun, Guo, Lida, Chen, Ka, Wu, Chuanyue

“…The interaction of cells with extracellular matrix recruits multiple proteins to cell-matrix contact sites (e.g. focal and fibrillar adhesions), which connect…”
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Formation and phosphorylation of the PINCH-1-integrin linked kinase-α-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival by YANQIANG YANG, LIDA GUO, BLATTNER, Simone M, MUNDEL, Peter, KRETZLER, Matthias, CHUANYUE WU

“…Alterations in the cellular architecture, adhesion, and/or loss of glomerular podocytes are causal factors in the development of proteinuria and the…”
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CH-ILKBP Regulates Cell Survival by Facilitating the Membrane Translocation of Protein Kinase B/Akt by Fukuda, Tomohiko, Guo, Lida, Shi, Xiaohua, Wu, Chuanyue

“…Cell survival depends on proper propagation of protective signals through intracellular signaling intermediates. We report here that calponin homology…”
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Role of the integrin-linked kinase PINCH1 alpha-parvin complex in cardiac myocyte hypertrophy by HUA CHEN, HUANG, Xueyin N, WEN YAN, KA CHEN, LIDA GUO, TUMMALAPALI, Lekha, DEDHAR, Shoukat, ST-ARNAUD, René, CHUANYUE WU, SEPULVEDA, Jorge L

“…Outside-in signaling from fibronectin (FN) through integrin receptors has been shown to play an important role in promoting cardiac myocyte hypertrophy and…”
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Osteopetrosis with micro-lacunar resorption because of defective integrin organization by Blair, Harry C, Yaroslavskiy, Beatrice B, Robinson, Lisa J, Mapara, Markus Y, Pangrazio, Alessandra, Guo, Lida, Chen, Ka, Vezzoni, Paolo, Tolar, Jakub, Orchard, Paul J

“…In vitro differentiated monocytes were used to characterize the cellular defect in a type of osteopetrosis with minimally functional osteoclasts, in which…”
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The Distribution and Regulation of Integrin-Linked Kinase in Normal and Diabetic Kidneys by Guo, Lida, Sanders, Paul W., Woods, Anne, Wu, Chuanyue

“…Alteration in cell adhesion and extracellular matrix deposition is a hallmark of diabetic glomerulosclerosis. Integrin-linked kinase (ILK) is a recently…”
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Preclinical characterization of ABI-H2158, an HBV core inhibitor with dual mechanisms of action by Yan, Ran, Cai, Dawei, Zong, Yuhua, Guo, Lida, Zhou, Yi, Tang, Ariel, Li, Lichun, Huang, Qi, Colonno, Richard, Walker, Michael A.

“…The HBV core protein plays an integral role in multiple steps of the HBV lifecycle. Consequently, HBV core inhibitors interrupt multiple steps of the…”
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A novel class of orally-available small molecules potently inhibiting hepatitis B and D virus entry by Unchwaniwala, Nuruddin, Contreras, Heidi, Li, Jinghu Carl, Azimova, Dinara, Tan, Joseph, Guo, Lida, de Sousa, Francielle Tramontini Gomes, Stray, Kirsten, Shen, Michael, Yu, Jiaxin, Windisch, Marc P., Perron, Michel, Walker, Michael A., Delaney, William E., Zhong, Min

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