Search Results - "Guo, Hanmin"

Detecting local genetic correlations with scan statistics by Guo, Hanmin, Li, James J., Lu, Qiongshi, Hou, Lin

“…Genetic correlation analysis has quickly gained popularity in the past few years and provided insights into the genetic etiology of numerous complex diseases…”
Get full text

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics by Miao, Jiacheng, Guo, Hanmin, Song, Gefei, Zhao, Zijie, Hou, Lin, Lu, Qiongshi

“…Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of Europeans are known to have substantially reduced predictive accuracy in…”
Get full text

Quantifying concordant genetic effects of de novo mutations on multiple disorders by Guo, Hanmin, Hou, Lin, Shi, Yu, Jin, Sheng Chih, Zeng, Xue, Li, Boyang, Lifton, Richard P, Brueckner, Martina, Zhao, Hongyu, Lu, Qiongshi

“…Exome sequencing on tens of thousands of parent-proband trios has identified numerous deleterious de novo mutations (DNMs) and implicated risk genes for many…”
Get full text

Prioritizing disease-related rare variants by integrating gene expression data by Guo, Hanmin, Urban, Alexander Eckehart, Wong, Wing Hung

“…Rare variants, comprising the vast majority of human genetic variations, are likely to have more deleterious impact in the context of human diseases compared…”
Get full text

Minimal σ-field for flexible sufficient dimension reduction by Guo, Hanmin, Hou, Lin, Zhu, Yu

Get full text

80. IMPLICATION OF COMPLEX STRUCTURAL GENOME VARIATION IN THE GENETIC ARCHITECTURE OF NEUROPSYCHIATRIC DISORDERS: INSIGHTS FROM HUMAN POPULATION ANALYSIS AND FROM POSTMORTEM BRAINS OF INDIVIDUALS WITH PSYCHIATRIC DISORDERS by Zhou, Bo, Arthur, Joseph, Guo, Hanmin, Kim, Taeyoung, Huang, Yiling, Pattni, Reenal, Song, Giltae, Palejev, Dean, Dohna, Heinrich, Roussos, Panos, Kundaje, Anshul, Hallmayer, Joachim, Snyder, Michael, Wong, Wing, Urban, Alexander

“…Psychiatric disorders such as schizophrenia and bipolar disorder have a strong but complex genetic component to their etiology. Multiple candidate loci have…”
Get full text

Resolving the 22q11.2 deletion using CTLR-Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints by Zhou, Bo, Purmann, Carolin, Guo, Hanmin, Shin, GiWon, Huang, Yiling, Pattni, Reenal, Meng, Qingxi, Greer, Stephanie U, Roychowdhury, Tanmoy, Wood, Raegan N, Ho, Marcus, Dohna, Heinrich Zu, Abyzov, Alexej, Hallmayer, Joachim F, Wong, Wing H, Ji, Hanlee P, Urban, Alexander E

“…We developed a generally applicable method, CRISPR/Cas9-targeted long-read sequencing (CTLR-Seq), to resolve, haplotype-specifically, the large and complex…”
Get full text