Search Results - "Guo, Edward"

Mechanical stress determines the configuration of TGFβ activation in articular cartilage by Zhen, Gehua, Guo, Qiaoyue, Li, Yusheng, Wu, Chuanlong, Zhu, Shouan, Wang, Ruomei, Guo, X. Edward, Kim, Byoung Choul, Huang, Jessie, Hu, Yizhong, Dan, Yang, Wan, Mei, Ha, Taekjip, An, Steven, Cao, Xu

“…Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional…”
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Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1 by Kajimura, Daisuke, Lee, Ha Won, Riley, Kyle J., Arteaga-Solis, Emilio, Ferron, Mathieu, Zhou, Bin, Clarke, Christopher J., Hannun, Yusuf A., DePinho, Ronald A., Guo, X. Edward, Mann, J. John, Karsenty, Gerard

“…The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin…”
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Optimizing the medium perfusion rate in bone tissue engineering bioreactors by Grayson, Warren L., Marolt, Darja, Bhumiratana, Sarindr, Fröhlich, Mirjam, Guo, X. Edward, Vunjak-Novakovic, Gordana

“…There is a critical need to increase the size of bone grafts that can be cultured in vitro for use in regenerative medicine. Perfusion bioreactors have been…”
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Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones by Jepsen, Karl J, Silva, Matthew J, Vashishth, Deepak, Guo, X Edward, van der Meulen, Marjolein CH

“…ABSTRACT Mice are widely used in studies of skeletal biology, and assessment of their bones by mechanical testing is a critical step when evaluating the…”
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Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics by Liu, Xiyu, Yan, Zedong, Cai, Jing, Wang, Dan, Yang, Yongqing, Ding, Yuanjun, Shao, Xi, Hao, Xiaoxia, Luo, Erping, Guo, X Edward, Luo, Peng, Shen, Liangliang, Jing, Da

“…Disuse osteoporosis is a metabolic bone disease resulting from skeletal unloading (e.g., during extended bed rest, limb immobilization, and spaceflight), and…”
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Dependence of mechanical properties of trabecular bone on plate–rod microstructure determined by individual trabecula segmentation (ITS) by Zhou, Bin, Sherry Liu, X, Wang, Ji, Lucas Lu, X, Fields, Aaron J, Edward Guo, X

“…Abstract Individual trabecula segmentation (ITS) technique can decompose the trabecular bone network into individual trabecular plates and rods and is capable…”
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Human bone perivascular niche-on-a-chip for studying metastatic colonization by Marturano-Kruik, Alessandro, Nava, Michele Maria, Yeager, Keith, Chramiec, Alan, Hao, Luke, Robinson, Samuel, Guo, Edward, Raimondi, Manuela Teresa, Vunjak-Novakovic, Gordana

“…Eight out of 10 breast cancer patients die within 5 years after the primary tumor has spread to the bones. Tumor cells disseminated from the breast roam the…”
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Spine Volumetric BMD and Strength in Premenopausal Idiopathic Osteoporosis: Effect of Teriparatide Followed by Denosumab by Agarwal, Sanchita, Shane, Elizabeth, Lang, Thomas, Shiau, Stephanie, Kamanda-Kosseh, Mafo, Bucovsky, Mariana, Lappe, Joan M, Stubby, Julie, Recker, Robert R, Hu, Yizhong, Wang, Zexi, Edward Guo, X, Cohen, Adi

“…Premenopausal women with idiopathic osteoporosis (PreMenIOP) have marked deficits in bone density, microstructure, and strength. To define effects of treatment…”
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Bariatric Surgery Results in Cortical Bone Loss by Stein, Emily M, Carrelli, Angela, Young, Polly, Bucovsky, Mariana, Zhang, Chiyuan, Schrope, Beth, Bessler, Marc, Zhou, Bin, Wang, Ji, Guo, X. Edward, McMahon, Donald J, Silverberg, Shonni J

“…Background: Bariatric surgery results in bone loss at weight-bearing sites, the mechanism of which is unknown. Methods: Twenty-two women (mean body mass index…”
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A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice by Luo, Na, Mosialou, Ioanna, Capulli, Mattia, Bisikirska, Brygida, Lin, Chyuan-Sheng, Huang, Yung-Yu, Shyu, Peter T, Guo, X Edward, Economides, Aris, Mann, J John, Kousteni, Stavroula

“…The various functions of the skeleton are influenced by extracellular cues, hormones, and neurotransmitters. One type of neuronal regulation favors bone mass…”
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Commonality in the microarchitecture of trabecular bone: A preliminary study by Zhao, Feng, Kirby, Matthew, Roy, Anuradha, Hu, Yizhong, Guo, X. Edward, Wang, Xiaodu

“…Understanding the relationship between the microstructure and mechanical function of trabecular bone is critical for prediction and prevention of bone…”
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miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2 by Wei, Jianwen, Shi, Yu, Zheng, Lihua, Zhou, Bin, Inose, Hiroyuki, Wang, Ji, Guo, X Edward, Grosschedl, Rudolf, Karsenty, Gerard

“…A screen of microRNAs preferentially expressed in osteoblasts identified members of the miR-34 family as regulators of osteoblast proliferation and/or…”
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Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis by Chen, Yan, Hu, Yizhong, Yu, Y Eric, Zhang, Xingjian, Watts, Tezita, Zhou, Bin, Wang, Ji, Wang, Ting, Zhao, Weiwei, Chiu, Kwong Yuen, Leung, Frankie KL, Cao, Xu, Macaulay, William, Nishiyama, Kyle K, Shane, Elizabeth, Lu, William W, Guo, X Edward

“…ABSTRACT Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has remained a challenge, primarily because of limited…”
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Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect by Ortuño, María José, Robinson, Samuel T, Subramanyam, Prakash, Paone, Riccardo, Huang, Yung-yu, Guo, X Edward, Colecraft, Henry M, Mann, J John, Ducy, Patricia

“…Long-term use of serotonin-reuptake inhibitors causes bone loss by acting centrally to counteract a peripheral, beneficial effect on bone. The use of selective…”
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Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis by Fu, Wenyu, Vasylyev, Dmytro, Bi, Yufei, Zhang, Mingshuang, Sun, Guodong, Khleborodova, Asya, Huang, Guiwu, Zhao, Libo, Zhou, Renpeng, Li, Yonggang, Liu, Shujun, Cai, Xianyi, He, Wenjun, Cui, Min, Zhao, Xiangli, Hettinghouse, Aubryanna, Good, Julia, Kim, Ellen, Strauss, Eric, Leucht, Philipp, Schwarzkopf, Ran, Guo, Edward X., Samuels, Jonathan, Hu, Wenhuo, Attur, Mukundan, Waxman, Stephen G., Liu, Chuan-ju

“…Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain 1…”
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Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone by Wang, Ji, Zhou, Bin, Liu, X. Sherry, Fields, Aaron J, Sanyal, Arnav, Shi, Xiutao, Adams, Mark, Keaveny, Tony M, Guo, X. Edward

“…Abstract The microstructure of trabecular bone is usually perceived as a collection of plate-like and rod-like trabeculae, which can be determined from the…”
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Engineering anatomically shaped human bone grafts by Grayson, Warren L, Fröhlich, Mirjam, Yeager, Keith, Bhumiratana, Sarindr, Chan, M. Ete, Cannizzaro, Christopher, Wan, Leo Q, Liu, X. Sherry, Guo, X. Edward, Vunjak-Novakovic, Gordana

“…The ability to engineer anatomically correct pieces of viable and functional human bone would have tremendous potential for bone reconstructions after…”
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Transient neonatal shoulder paralysis causes early osteoarthritis in a mouse model by Forrester, Lynn Ann, Fang, Fei, Jacobsen, Timothy, Hu, Yizhong, Kurtaliaj, Iden, Roye, Benjamin D., Edward Guo, X., Chahine, Nadeen O., Thomopoulos, Stavros

“…Neonatal brachial plexus palsy (NBPP) occurs in approximately 1.5 of every 1,000 live births. The majority of children with NBPP recover function of the…”
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The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: Involvement of osteoprotegerin by Peng, Songlin, Liu, X. Sherry, Huang, Shishu, Li, Zhaoyang, Pan, Haobo, Zhen, Wanxin, Luk, K.D.K, Guo, X. Edward, Lu, W. William

“…Abstract Background The mechanism for the uncoupling effects of Sr on bone remains to be evaluated. Osteoblasts play important roles in osteoclastogenesis…”
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Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow by Lu, X Lucas, Huo, Bo, Chiang, Victor, Guo, X Edward

“…Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular…”
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