Search Results - "Guo, Chaohuan"

Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation by Guo, Chaohuan, Fu, Rong, Zhou, Mianjing, Wang, Shuang, Huang, Yuefang, Hu, Haoqiang, Zhao, Jijun, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man

“…RIP3 activation leads to activation of necroptosis and the NLRP3 inflammasome pathways. The activation of RIP3 in lupus nephritis (LN) has not been…”
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Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis by Fu, Rong, Guo, Chaohuan, Wang, Shuang, Huang, Yuefang, Jin, Ou, Hu, Haoqiang, Chen, Jingxian, Xu, Bihua, Zhou, Mianjing, Zhao, Jijun, Sung, Sun‐sang J., Wang, Hongyang, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man

“…Objective Development of proteinuria in lupus nephritis (LN) is associated with podocyte dysfunction. The NLRP3 inflammasome has been implicated in the…”
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Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages by Zhang, Hui, Fu, Rong, Guo, Chaohuan, Huang, Yuefang, Wang, Hongyue, Wang, Shuang, Zhao, Jijun, Yang, Niansheng

“…NLRP3 inflammasome has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The activation of NLRP3 inflammasome results in the…”
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Activation of necroptosis pathway in podocyte contributes to the pathogenesis of focal segmental glomerular sclerosis by Hu, Haoqiang, Li, Mengyuan, Chen, Binfeng, Guo, Chaohuan, Yang, Niansheng

“…Background Focal segmental glomerulosclerosis (FSGS) is characterized by podocyte damage and severe proteinuria. The exact mechanism of podocyte damage and…”
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CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell by Zhang, Tengyue, Li, Mengyuan, Zhao, Siyuan, Zhou, Mianjing, Liao, Huai, Wu, Haiyan, Mo, Xinyue, Wang, Hongxing, Guo, Chaohuan, Zhang, Hui, Yang, Niansheng, Huang, Yuefang

“…Background Type II alveolar epithelial cell (AEC II), in addition to its roles in maintaining lung homeostasis, takes an active role in inflammatory response…”
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CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis by Li, Xue, Zeng, Qin, Wang, Shuyi, Li, Mengyuan, Chen, Xionghui, Huang, Yuefang, Chen, Binfeng, Zhou, Mianjing, Lai, Yimei, Guo, Chaohuan, Zhao, Siyuan, Zhang, Hui, Yang, Niansheng

“…Store-operated Ca release-activated Ca (CRAC) channel is the main Ca influx pathway in lymphocytes and is essential for immune response. Lupus nephritis (LN)…”
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Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy by Lai, Yimei, Zhao, Siyuan, Chen, Binfeng, Huang, Yuefang, Guo, Chaohuan, Li, Mengyuan, Ye, Baokui, Wang, Shuyi, Zhang, Hui, Yang, Niansheng

“…Background T helper cells in patients with autoimmune disease of idiopathic inflammatory myopathies (IIM) are characterized with the proinflammatory…”
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JAK/STAT signaling controls the fate of CD8+CD103+ tissue-resident memory T cell in lupus nephritis by Zhou, Mianjing, Guo, Chaohuan, Li, Xue, Huang, Yuefang, Li, Mengyuan, Zhang, Tengyue, Zhao, Siyuan, Wang, Shuang, Zhang, Hui, Yang, Niansheng

“…Autoimmune mediated inflammation and renal damage in lupus nephritis (LN) depends partly on the infiltration of lymphocytes in glomeruli and renal…”
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The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus by Xu, Bihua, Wang, Shuang, Zhou, Mianjing, Huang, Yuefang, Fu, Rong, Guo, Chaohuan, Chen, Jingxian, Zhao, Jijun, Gaskin, Felicia, Fu, Shu Man, Yang, Niansheng

“…Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic…”
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Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses by Zeng, Qin, Wang, Shuyi, Li, Mengyuan, Wang, Shuang, Guo, Chaohuan, Ruan, Xinyuan, Watanabe, Ryu, Lai, Yimei, Huang, Yuefang, Yin, Xiaoyu, Zhang, Chuanzhao, Chen, Binfeng, Yang, Niansheng, Zhang, Hui

“…Autoreactive B cell responses are essential for the development of systemic lupus erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to…”
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Pim‐1 as a Therapeutic Target in Lupus Nephritis by Fu, Rong, Xia, Yong, Li, Meirong, Mao, Renxiang, Guo, Chaohuan, Zhou, Mianjing, Tan, Hechang, Liu, Meiling, Wang, Shuang, Yang, Niansheng, Zhao, Jijun

“…Objective Lupus nephritis (LN) is a major determinant of morbidity and mortality in systemic lupus erythematosus (SLE). Pim‐1 regulates lymphocyte…”
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NAMPT is a metabolic checkpoint of IFNγ-producing CD4+ T cells in lupus nephritis by Li, Mengyuan, Lai, Yimei, Chen, Binfeng, Guo, Chaohuan, Zhou, Mianjing, Zhao, Siyuan, Wang, Shuyi, Li, Jin, Yang, Niansheng, Zhang, Hui

“…Interferon γ (IFNγ) produced by T cells represents the featured cytokine and is central to the pathogenesis of lupus nephritis (LN). Here, we identified…”
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C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis by Ye, Baokui, Chen, Binfeng, Guo, Chaohuan, Xiong, Ningjing, Huang, Yuefang, Li, Mengyuan, Lai, Yimei, Li, Jin, Zhou, Mianjing, Wang, Shuang, Wang, Shuyi, Yang, Niansheng, Zhang, Hui

“…Podocytes are essential to maintaining the integrity of the glomerular filtration barrier, but they are frequently affected in lupus nephritis (LN). Here, we…”
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Innate lymphoid cell disturbance with increase in ILC1 in systemic lupus erythematosus by Guo, Chaohuan, Zhou, Mianjing, Zhao, Siyuan, Huang, Yuefang, Wang, Shuang, Fu, Rong, Li, Mengyuan, Zhang, Tengyue, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man

“…The innate lymphoid cell (ILC) is a group of effector cells with diverse important cellular functions in both health and disease states. In comparison with…”
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Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts by Zhang, Hui, Huang, Yuefang, Wang, Shuang, Fu, Rong, Guo, Chaohuan, Wang, Hongyue, Zhao, Jijun, Gaskin, Felicia, Chen, Jingxian, Yang, Niansheng, Fu, Shu Man

“…Abstract Bone erosion is a sign of severe rheumatoid arthritis and osteoclasts play a major role in the bone resorption. Recently, myeloid-derived suppressor…”
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