Cytogenetic Events After Bone Marrow Transplantation for Chronic Myeloid Leukemia in Chronic Phase

Forty-eight patients treated by allogeneic bone marrow transplantation (BMT) for Philadelphia (Ph) chromosome-positive chronic myeloid leukemia in chronic phase had serial cytogenetic studies of marrow performed at intervals after transplant. Twenty patients received marrow cells from donors of oppo...

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Bibliographic Details
Published in:	Blood Vol. 71; no. 5; pp. 1179 - 1186
Main Authors:	Arthur, C.K., Apperley, J.F., Guo, A.P., Rassool, F., Gao, L.M., Goldman, J.M.
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 01-05-1988 The Americain Society of Hematology
Subjects:	Biological and medical sciences Bone Marrow Transplantation Chromosome Aberrations Evaluation Studies as Topic Female Hematologic and hematopoietic diseases Humans Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Depletion Male Medical sciences Philadelphia Chromosome Chromosomal aberration Human Ph1-Chromosome Genetic marker Homograft Various treatments Hemopathy Recipient Donor Chronic myelocytic leukemia Cytogenetics Bone marrow Abnormal chromosome
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Summary:	Forty-eight patients treated by allogeneic bone marrow transplantation (BMT) for Philadelphia (Ph) chromosome-positive chronic myeloid leukemia in chronic phase had serial cytogenetic studies of marrow performed at intervals after transplant. Twenty patients received marrow cells from donors of opposite sex. Ph+ marrow meta-phases were identified in 24 of 48 (50%) of patients after BMT; they were first seen early (within 1 year) in 16 cases and late (>1 year after BMT) in eight cases. Ph-positivity after BMT occurred more commonly in recipients of T-depleted than nondepleted marrow (19 of 28 v 5 of 20). In 4 cases the Ph + metaphases were found only transiently after BMT; in 11 cases the Ph + metaphases have persisted but hematologic relapse has not ensued; in 9 cases the finding of Ph + metaphases coincided with or preceded hematologic relapse. Chromosomes in cells of donor origin had morphological abnormalities in two cases. No relapses were identified in cells of donor origin. Our data suggest that the relationship between cells of recipient and donor origin is complex: cure of leukemia may depend on factors that operate for some months or years after BMT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.V71.5.1179.1179