Search Results - "Guntur, Anyonya R."

Energy Metabolism of the Osteoblast: Implications for Osteoporosis by Lee, Wen-Chih, Guntur, Anyonya R., Long, Fanxin, Rosen, Clifford J.

“…Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and maintenance of the skeleton. Clinical disorders of substrate…”
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Bioenergetics During Calvarial Osteoblast Differentiation Reflect Strain Differences in Bone Mass by Guntur, Anyonya R, Le, Phuong T, Farber, Charles R, Rosen, Clifford J

“…Osteoblastogenesis is the process by which mesenchymal stem cells differentiate into osteoblasts that synthesize collagen and mineralize matrix. The pace and…”
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The skeleton: a multi-functional complex organ. New insights into osteoblasts and their role in bone formation: the central role of PI3Kinase by Guntur, Anyonya R, Rosen, Clifford J

“…Studies on bone development, formation and turnover have grown exponentially over the last decade in part because of the utility of genetic models. One area…”
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Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton by Maridas, David E., Rendina-Ruedy, Elizabeth, Helderman, Ron C., DeMambro, Victoria E., Brooks, Daniel, Guntur, Anyonya R., Lanske, Beate, Bouxsein, Mary L., Rosen, Clifford J.

“…ABSTRACT Intermittent administration of parathyroid hormone (PTH) stimulates bone formation in vivo and also suppresses the volume of bone marrow adipose…”
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Osteoblast‐like MC3T3‐E1 Cells Prefer Glycolysis for ATP Production but Adipocyte‐like 3T3‐L1 Cells Prefer Oxidative Phosphorylation by Guntur, Anyonya R, Gerencser, Akos A, Le, Phuong T, DeMambro, Victoria E, Bornstein, Sheila A, Mookerjee, Shona A, Maridas, David E, Clemmons, David E, Brand, Martin D, Rosen, Clifford J

“…ABSTRACT Mesenchymal stromal cells (MSCs) are early progenitors that can differentiate into osteoblasts, chondrocytes, and adipocytes. We hypothesized that…”
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Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration by Tower, Robert J, Busse, Emily, Jaramillo, Josue, Lacey, Michelle, Hoffseth, Kevin, Guntur, Anyonya R, Simkin, Jennifer, Sammarco, Mimi C

“…De novo limb regeneration after amputation is restricted in mammals to the distal digit tip. Central to this regenerative process is the blastema, a…”
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A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome by Su, Su, Guntur, Anyonya R., Nguyen, Daniel C., Fakory, Shameem S., Doucette, Chad C., Leech, Cassandra, Lotana, Humphrey, Kelley, Matthew, Kohli, Jaspreet, Martino, Julieta, Sims-Lucas, Sunder, Liaw, Lucy, Vary, Calvin, Rosen, Clifford J., Brown, Aaron C.

“…Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous…”
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Purification of functional mouse skeletal muscle mitochondria using percoll density gradient centrifugation by Anunciado-Koza, Rea Victoria P, Guntur, Anyonya R, Vary, Calvin P, Gartner, Carlos A, Nowak, Madeleine, Koza, Robert A

“…Our goal was to isolate purified mitochondria from mouse skeletal muscle using a Percoll density gradient and to assess bioenergetic function and purity via…”
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Effects of PTH on osteoblast bioenergetics in response to glucose by DeMambro, Victoria E., Tian, Li, Karthik, Vivin, Rosen, Clifford J., Guntur, Anyonya R.

“…Parathyroid hormone acts through its receptor, PTHR1, expressed on osteoblasts, to control bone remodeling. Metabolic flexibility for energy generation has…”
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PHOSPHO1 is a skeletal regulator of insulin resistance and obesity by Suchacki, Karla J, Morton, Nicholas M, Vary, Calvin, Huesa, Carmen, Yadav, Manisha C, Thomas, Benjamin J, Turban, Sophie, Bunger, Lutz, Ball, Derek, Barrios-Llerena, Martin E, Guntur, Anyonya R, Khavandgar, Zohreh, Cawthorn, William P, Ferron, Mathieu, Karsenty, Gérard, Murshed, Monzur, Rosen, Clifford J, MacRae, Vicky E, Millán, Jose Luis, Farquharson, Colin

“…The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human…”
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A Novel ENU-Induced Mfn2 Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy by Hines, Timothy J, Bailey, Janice, Liu, Hedi, Guntur, Anyonya R, Seburn, Kevin L, Pratt, Samia L, Funke, Jonathan R, Tarantino, Lisa M, Burgess, Robert W

“…Mitochondrial fission and fusion are required for maintaining functional mitochondria. The mitofusins (MFN1 and MFN2) are known for their roles in mediating…”
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Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling by Guntur, Anyonya R, Reinhold, Martina I, Cuellar, Jr, Joe, Naski, Michael C

“…Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a direct antagonist of phosphatidylinositol 3 kinase. Pten is a well recognized tumor…”
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An essential role for the circadian-regulated gene Nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis by Guntur, Anyonya R., Kawai, Masanobu, Le, Phuong, Bouxsein, Mary L., Bornstein, Sheila, Green, Carla B., Rosen, Clifford J.

“…The role of circadian proteins in regulating whole‐body metabolism and bone turnover has been studied in detail and has led to the discovery of an elemental…”
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Conditional deletion of cytochrome p450 reductase in osteoprogenitor cells affects long bone and skull development in mice recapitulating antley-bixler syndrome: role of a redox enzyme in development by Panda, Satya P, Guntur, Anyonya R, Polusani, Srikanth R, Fajardo, Roberto J, Gakunga, Peter T, Roman, Linda J, Masters, Bettie Sue

“…NADPH-cytochrome P450 oxidoreductase (POR) is the primary electron donor for cytochromes P450, dehydrocholesterol reductase, heme oxygenase, and squalene…”
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Role of autophagy in intervertebral disc and cartilage function: implications in health and disease by Madhu, Vedavathi, Guntur, Anyonya R., Risbud, Makarand V.

“…•Hypoxia, an important niche factor in disc and cartilage affects baseline autophagy.•Dysregulation of autophagic and mitophagic pathways affect disc and…”
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Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF‐1α–BNIP3 Axis by Madhu, Vedavathi, Boneski, Paige K, Silagi, Elizabeth, Qiu, Yunping, Kurland, Irwin, Guntur, Anyonya R, Shapiro, Irving M, Risbud, Makarand V

“…ABSTRACT Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the intervertebral disc and are predominantly glycolytic due to…”
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Energy Metabolism of Osteocytes by Karthik, Vivin, Guntur, Anyonya R

“…Purpose of Review In this review, we provide a recent update on bioenergetic pathways in osteocytes and identify potential future areas of research interest…”
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The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice by Fujiwara, Makoto, Tian, Li, Le, Phuong T., DeMambro, Victoria E., Becker, Kathleen A., Rosen, Clifford J., Guntur, Anyonya R.

“…Metabolic programming of bone marrow stromal cells (BMSCs) could influence the function of progenitor osteoblasts or adipocytes and hence determine skeletal…”
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The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc by Madhu, Vedavathi, Hernandez-Meadows, Miriam, Boneski, Paige K, Qiu, Yunping, Guntur, Anyonya R, Kurland, Irwin J., Barve, Ruteja A, Risbud, Makarand V.

“…The contribution of mitochondria to the metabolic function of hypoxic NP cells has been overlooked. We have shown that NP cells contain networked mitochondria…”
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Mitochondrial Function and Metabolism of Cultured Skeletal Cells by Tian, Li, Rosen, Clifford J, Guntur, Anyonya R

“…Measuring cellular metabolism accurately is necessary to understand bioenergetic pathways in cells. The major ATP generating pathways in cells are oxidative…”
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