Search Results - "Gunst, Jan"

Recovery from critical illness-induced organ failure: the role of autophagy by Gunst, Jan

“…Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a…”
Get full text

Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different? by Langouche, Lies, Van den Berghe, Greet, Gunst, Jan

“…Keywords: COVID-19, Hyperglycemia, Insulin, Diabetes…”
Get full text

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb by Khan, Mona, Yoo, Seung-Jun, Clijsters, Marnick, Backaert, Wout, Vanstapel, Arno, Speleman, Kato, Lietaer, Charlotte, Choi, Sumin, Hether, Tyler D., Marcelis, Lukas, Nam, Andrew, Pan, Liuliu, Reeves, Jason W., Van Bulck, Pauline, Zhou, Hai, Bourgeois, Marc, Debaveye, Yves, De Munter, Paul, Gunst, Jan, Jorissen, Mark, Lagrou, Katrien, Lorent, Natalie, Neyrinck, Arne, Peetermans, Marijke, Thal, Dietmar Rudolf, Vandenbriele, Christophe, Wauters, Joost, Mombaerts, Peter, Van Gerven, Laura

“…Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory…”
Get full text

Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study by Van Aerde, Nathalie, Meersseman, Philippe, Debaveye, Yves, Wilmer, Alexander, Gunst, Jan, Casaer, Michael P., Bruyninckx, Frans, Wouters, Pieter J., Gosselink, Rik, Van den Berghe, Greet, Hermans, Greet

“…Purpose To assess the independent association between ICU-acquired neuromuscular complications and 5-year mortality and morbidity. To explore the optimal…”
Get full text

Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality by Meyfroidt, Geert, Gunst, Jan, Martin-Loeches, Ignacio, Smith, Martin, Robba, Chiara, Taccone, Fabio Silvio, Citerio, Giuseppe

“…Purpose To provide a practical overview of the management of the potential organ donor in the intensive care unit. Methods Seven areas of donor management were…”
Get full text

Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs? by Gunst, Jan, Casaer, Michael P, Preiser, Jean-Charles, Reignier, Jean, Van den Berghe, Greet

“…Although numerous observational studies associated underfeeding with poor outcome, recent randomized controlled trials (RCTs) have shown that early full…”
Get full text

AKIpredictor, an online prognostic calculator for acute kidney injury in adult critically ill patients: development, validation and comparison to serum neutrophil gelatinase-associated lipocalin by Flechet, Marine, Güiza, Fabian, Schetz, Miet, Wouters, Pieter, Vanhorebeek, Ilse, Derese, Inge, Gunst, Jan, Spriet, Isabel, Casaer, Michaël, Van den Berghe, Greet, Meyfroidt, Geert

“…Purpose Early diagnosis of acute kidney injury (AKI) remains a major challenge. We developed and validated AKI prediction models in adult ICU patients and made…”
Get full text

Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial by Hermans, Greet, MD, Casaer, Michael P, MD, Clerckx, Beatrix, PT, Güiza, Fabian, PhD, Vanhullebusch, Tine, PT, Derde, Sarah, PhD, Meersseman, Philippe, MD, Derese, Inge, BSc, Mesotten, Dieter, MD, Wouters, Pieter J, MSc, Van Cromphaut, Sophie, MD, Debaveye, Yves, MD, Gosselink, Rik, PhD, Gunst, Jan, MD, Wilmer, Alexander, MD, Van den Berghe, Greet, Dr MD, Vanhorebeek, Ilse, PhD

“…Summary Background Patients who are critically ill can develop so-called intensive-care unit acquired weakness, which delays rehabilitation. Reduced muscle…”
Get full text

Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome by De Bruyn, Astrid, Langouche, Lies, Vander Perre, Sarah, Gunst, Jan, Van den Berghe, Greet

“…SEE PDF] We first performed a time course analysis in a propensity-score-matched subset of 110 patients (Table 1), to study whether late-PN enhanced…”
Get full text

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host by Lloréns-Rico, Verónica, Gregory, Ann C., Van Weyenbergh, Johan, Jansen, Sander, Van Buyten, Tina, Qian, Junbin, Braz, Marcos, Menezes, Soraya Maria, Van Mol, Pierre, Vanderbeke, Lore, Dooms, Christophe, Gunst, Jan, Hermans, Greet, Meersseman, Philippe, Wauters, Els, Neyts, Johan, Lambrechts, Diether, Wauters, Joost, Raes, Jeroen

“…Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease…”
Get full text

Insufficient Autophagy Contributes to Mitochondrial Dysfunction, Organ Failure, and Adverse Outcome in an Animal Model of Critical Illness by GUNST, Jan, DERESE, Inge, AERTGEERTS, Annelies, VERVERS, Eric-Jan, WAUTERS, Andy, VAN DEN BERGHE, Greet, VANHOREBEEK, Ilse

“…Increasing evidence implicates mitochondrial dysfunction as an early, important event in the pathogenesis of critical illness-induced multiple organ failure…”
Get full text

The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: Gaps in current knowledge and future translational research directions by Van den Berghe, Greet, Téblick, Arno, Langouche, Lies, Gunst, Jan

“…The classical model of the vital increase in systemic glucocorticoid availability in response to sepsis- and hyperinflammation-induced critical illness is one…”
Get full text

Acute kidney injury in critical COVID-19: a multicenter cohort analysis in seven large hospitals in Belgium by Schaubroeck, Hannah, Vandenberghe, Wim, Boer, Willem, Boonen, Eva, Dewulf, Bram, Bourgeois, Camille, Dubois, Jasperina, Dumoulin, Alexander, Fivez, Tom, Gunst, Jan, Hermans, Greet, Lormans, Piet, Meersseman, Philippe, Mesotten, Dieter, Stessel, Björn, Vanhoof, Marc, De Vlieger, Greet, Hoste, Eric

“…Acute kidney injury (AKI) has been reported as a frequent complication of critical COVID-19. We aimed to evaluate the occurrence of AKI and use of kidney…”
Get full text

Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit by De Bruyn, Astrid, Gunst, Jan, Goossens, ChloÃ, Vander Perre, Sarah, Guerra, Gonzalo G, Verbruggen, Sascha, Joosten, Koen, Langouche, Lies, Van den Berghe, Greet

“…Abstract Background In critically ill children, omitting early use of parenteral nutrition (late-PN versus early-PN) reduced infections, accelerated weaning…”
Get full text

Autophagy and Its Implications Against Early Full Nutrition Support in Critical Illness by Dyck, Lisa, Casaer, Michaël P., Gunst, Jan

“…The timing, dose, and route of early nutrition support in critically ill patients have been highly controversial for years. Despite the association of a…”
Get full text

Personalized nutrition therapy in critical care: 10 expert recommendations by Wischmeyer, Paul E, Bear, Danielle E, Berger, Mette M, De Waele, Elisabeth, Gunst, Jan, McClave, Stephen A, Prado, Carla M, Puthucheary, Zudin, Ridley, Emma J, Van den Berghe, Greet, van Zanten, Arthur R H

“…Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions…”
Get full text

Is protein intake saturated at doses recommended by the feeding guidelines for critically ill patients? by Gunst, Jan, Casaer, Michael P

Get full text

Effect of early supplemental parenteral nutrition in the paediatric ICU: a preplanned observational study of post-randomisation treatments in the PEPaNIC trial by Vanhorebeek, Ilse, PhD, Verbruggen, Sascha, MD, Casaer, Michaël P, MD, Gunst, Jan, MD, Wouters, Pieter J, MSc, Hanot, Jan, MD, Guerra, Gonzalo Garcia, MD, Vlasselaers, Dirk, MD, Joosten, Koen, MD, Van den Berghe, Greet, Prof

“…Summary Background Large randomised controlled trials have shown that early supplemental parenteral nutrition in patients admitted to adult and paediatric…”
Get full text

Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients by Vanhorebeek, Ilse, Gunst, Jan, Derde, Sarah, Derese, Inge, Boussemaere, Magaly, Güiza, Fabian, Martinet, Wim, Timmermans, Jean-Pierre, D'Hoore, André, Wouters, Pieter J, Van den Berghe, Greet

“…Insufficient autophagy resulting in inadequate clearance of cellular damage could explain lack of recovery from organ failure in the prolonged critically ill…”
Get full text

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients by Gunst, Jan, De Bruyn, Astrid, Casaer, Michael P, Vander Perre, Sarah, Langouche, Lies, Van den Berghe, Greet

“…Recent evidence suggests a potentially protective effect of increasing ketone body availability via accepting low macronutrient intake early after onset of…”
Get full text