Search Results - "Gunning, Peter W."

Tropomyosin - master regulator of actin filament function in the cytoskeleton by Gunning, Peter W, Hardeman, Edna C, Lappalainen, Pekka, Mulvihill, Daniel P

“…Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin filaments in fungi and metazoans. Tpms are coiled-coil parallel…”
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The evolution of compositionally and functionally distinct actin filaments by Gunning, Peter W, Ghoshdastider, Umesh, Whitaker, Shane, Popp, David, Robinson, Robert C

“…The actin filament is astonishingly well conserved across a diverse set of eukaryotic species. It has essentially remained unchanged in the billion years that…”
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A Molecular Pathway for Myosin II Recruitment to Stress Fibers by Tojkander, Sari, Gateva, Gergana, Schevzov, Galina, Hotulainen, Pirta, Naumanen, Perttu, Martin, Claire, Gunning, Peter W., Lappalainen, Pekka

“…Cell migration and morphogenesis are driven by both protrusive and contractile actin filament structures. The assembly mechanisms of lamellipodial and…”
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Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro by Gateva, Gergana, Kremneva, Elena, Reindl, Theresia, Kotila, Tommi, Kogan, Konstantin, Gressin, Laurène, Gunning, Peter W., Manstein, Dietmar J., Michelot, Alphée, Lappalainen, Pekka

“…Actin filaments assemble into a variety of networks to provide force for diverse cellular processes [1]. Tropomyosins are coiled-coil dimers that form…”
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A systematic nomenclature for mammalian tropomyosin isoforms by Geeves, Michael A., Hitchcock-DeGregori, Sarah E., Gunning, Peter W.

“…Tropomyosin, a ubiquitous protein in animals and fungi, is associated with the actin cytoskeleton and is involved with stabilising actin filaments and…”
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Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling by Lim, Chun-Yan, Bi, Xuezhi, Wu, Donghai, Kim, Jae Bum, Gunning, Peter W., Hong, Wanjin, Han, Weiping

“…Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV) translocation and fusion with the plasma membrane (PM). Using mass…”
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Focal adhesions contain three specialized actin nanoscale layers by Kumari, Reena, Ven, Katharina, Chastney, Megan, Kokate, Shrikant B., Peränen, Johan, Aaron, Jesse, Kogan, Konstantin, Almeida-Souza, Leonardo, Kremneva, Elena, Poincloux, Renaud, Chew, Teng-Leong, Gunning, Peter W., Ivaska, Johanna, Lappalainen, Pekka

“…Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies…”
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Highly efficient platelet generation in lung vasculature reproduced by microfluidics by Zhao, Xiaojuan, Alibhai, Dominic, Walsh, Tony G., Tarassova, Nathalie, Englert, Maximilian, Birol, Semra Z., Li, Yong, Williams, Christopher M., Neal, Chris R., Burkard, Philipp, Cross, Stephen J., Aitken, Elizabeth W., Waller, Amie K., Beltrán, José Ballester, Gunning, Peter W., Hardeman, Edna C., Agbani, Ejaife O., Nieswandt, Bernhard, Hers, Ingeborg, Ghevaert, Cedric, Poole, Alastair W.

“…Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying…”
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Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects by Wang, Yao, Stear, Jeffrey H, Swain, Ashleigh, Xu, Xing, Bryce, Nicole S, Carnell, Michael, Alieva, Irina B, Dugina, Vera B, Cripe, Timothy P, Stehn, Justine, Hardeman, Edna C, Gunning, Peter W

“…Antimicrotubule vinca alkaloids are widely used in the clinic but their toxicity is often dose limiting. Strategies that enhance their effectiveness at lower…”
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Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton by Jalilian, Iman, Heu, Celine, Cheng, Hong, Freittag, Hannah, Desouza, Melissa, Stehn, Justine R, Bryce, Nicole S, Whan, Renee M, Hardeman, Edna C, Fath, Thomas, Schevzov, Galina, Gunning, Peter W

“…The actin cytoskeleton is the primary polymer system within cells responsible for regulating cellular stiffness. While various actin binding proteins regulate…”
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Fundamental differences by Gunning, Peter W, Hardeman, Edna C

“…The differences between β- and γ-actin are deeper than those between the amino acid sequences of these two proteins…”
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Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans by Hook, Jeff W, Seto, Jane T, Gunning, Peter W, MacArthur, Daniel G, Quinlan, Kate G, Huttley, Gavin A, Lemckert, Frances A, Hardeman, Edna C, Edwards, Michael R, Berman, Yemima, Easteal, Simon, Kee, Anthony J, North, Kathryn N, Yang, Nan, Raftery, Joanna M

“…More than a billion humans worldwide are predicted to be completely deficient in the fast skeletal muscle fiber protein α-actinin-3 owing to homozygosity for a…”
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Overexpression of Tropomyosin Isoform Tpm3.1 Does Not Alter Synaptic Function in Hippocampal Neurons by Chaichim, Chanchanok, Tomanic, Tamara, Stefen, Holly, Paric, Esmeralda, Gamaroff, Lucy, Suchowerska, Alexandra K., Gunning, Peter W., Ke, Yazi D., Fath, Thomas, Power, John

“…Tropomyosin (Tpm) has been regarded as the master regulator of actin dynamics. Tpms regulate the binding of the various proteins involved in restructuring…”
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Tropomyosin isoforms: divining rods for actin cytoskeleton function by Gunning, Peter W., Schevzov, Galina, Kee, Anthony J., Hardeman, Edna C.

“…Actin filament functional diversity is paralleled by variation in the composition of isoforms of tropomyosin in these filaments. Although the role of…”
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A robust method for particulate detection of a genetic tag for 3D electron microscopy by Rae, James, Ferguson, Charles, Ariotti, Nicholas, Webb, Richard I, Cheng, Han-Hao, Mead, James L, Riches, James D, Hunter, Dominic Jb, Martel, Nick, Baltos, Joanne, Christopoulos, Arthur, Bryce, Nicole S, Cagigas, Maria Lastra, Fonseka, Sachini, Sayre, Marcel E, Hardeman, Edna C, Gunning, Peter W, Gambin, Yann, Hall, Thomas E, Parton, Robert G

“…Genetic tags allow rapid localization of tagged proteins in cells and tissues. APEX, an ascorbate peroxidase, has proven to be one of the most versatile and…”
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Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin by Koestler, Stefan A, Steffen, Anika, Nemethova, Maria, Winterhoff, Moritz, Luo, Ningning, Holleboom, J Margit, Krupp, Jessica, Jacob, Sonja, Vinzenz, Marlene, Schur, Florian, Schlüter, Kai, Gunning, Peter W, Winkler, Christoph, Schmeiser, Christian, Faix, Jan, Stradal, Theresia E B, Small, J Victor, Rottner, Klemens

“…Lamellipodia are sheet-like protrusions formed during migration or phagocytosis and comprise a network of actin filaments. Filament formation in this network…”
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Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue by Erami, Zahra, Herrmann, David, Warren, Sean C., Nobis, Max, McGhee, Ewan J., Lucas, Morghan C., Leung, Wilfred, Reischmann, Nadine, Mrowinska, Agata, Schwarz, Juliane P., Kadir, Shereen, Conway, James R.W., Vennin, Claire, Karim, Saadia A., Campbell, Andrew D., Gallego-Ortega, David, Magenau, Astrid, Murphy, Kendelle J., Ridgway, Rachel A., Law, Andrew M., Walters, Stacey N., Grey, Shane T., Croucher, David R., Zhang, Lei, Herzog, Herbert, Hardeman, Edna C., Gunning, Peter W., Ormandy, Christopher J., Evans, T.R. Jeffry, Strathdee, Douglas, Sansom, Owen J., Morton, Jennifer P., Anderson, Kurt I., Timpson, Paul

“…E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in…”
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Spatial localisation of actin filaments across developmental stages of the malaria parasite by Angrisano, Fiona, Riglar, David T, Sturm, Angelika, Volz, Jennifer C, Delves, Michael J, Zuccala, Elizabeth S, Turnbull, Lynne, Dekiwadia, Chaitali, Olshina, Maya A, Marapana, Danushka S, Wong, Wilson, Mollard, Vanessa, Bradin, Clare H, Tonkin, Christopher J, Gunning, Peter W, Ralph, Stuart A, Whitchurch, Cynthia B, Sinden, Robert E, Cowman, Alan F, McFadden, Geoffrey I, Baum, Jake

“…Actin dynamics have been implicated in a variety of developmental processes during the malaria parasite lifecycle. Parasite motility, in particular, is thought…”
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Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment by Abouelezz, Amr, Stefen, Holly, Segerstråle, Mikael, Micinski, David, Minkeviciene, Rimante, Lahti, Lauri, Hardeman, Edna C., Gunning, Peter W., Hoogenraad, Casper C., Taira, Tomi, Fath, Thomas, Hotulainen, Pirta

“…The axon initial segment (AIS) is the site of action potential initiation and serves as a cargo transport filter and diffusion barrier that helps maintain…”
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Recruitment Kinetics of Tropomyosin Tpm3.1 to Actin Filament Bundles in the Cytoskeleton Is Independent of Actin Filament Kinetics by Appaduray, Mark A, Masedunskas, Andrius, Bryce, Nicole S, Lucas, Christine A, Warren, Sean C, Timpson, Paul, Stear, Jeffrey H, Gunning, Peter W, Hardeman, Edna C

“…The actin cytoskeleton is a dynamic network of filaments that is involved in virtually every cellular process. Most actin filaments in metazoa exist as a…”
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