Search Results - "Gunn, David E."

Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications by Van Zandt, Michael C, Jones, Michael L, Gunn, David E, Geraci, Leo S, Jones, J. Howard, Sawicki, Diane R, Sredy, Janet, Jacot, Jorge L, DiCioccio, A. Thomas, Petrova, Tatiana, Mitschler, Andre, Podjarny, Alberto D

“…Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective…”
Get full text

Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist by Lin, Nan-Horng, Gunn, David E, Li, Yihong, He, Yun, Bai, Hao, Ryther, Keith B, Kuntzweiler, Theresa, Donnelly-Roberts, Diana L, Anderson, David J, Campbell, Jeffrey E, Sullivan, James P, Arneric, Stephen P, Holladay, Mark W

“…Analogs of 3-[2-(( S)-pyrrolidinyl)methoxy]pyridine (A-84543, 1) with 2-, 4-, 5-, and 6-substituents on the pyridine ring were synthesized. These analogs…”
Get full text

Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors by Abreo, Melwyn A, Lin, Nan-Horng, Garvey, David S, Gunn, David E, Hettinger, Ann-Marie, Wasicak, James T, Pavlik, Patricia A, Martin, Yvonne C, Donnelly-Roberts, Diana L, Anderson, David J, Sullivan, James P, Williams, Michael, Arneric, Stephen P, Holladay, Mark W

“…Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as…”
Get full text

Calibration of marine sediment core loggers for quantitative acoustic impedance studies by Best, Angus I, Gunn, David E

“…Accurate density and P-wave velocity measurements on marine sediment cores are needed for quantitative acoustic impedance studies. An increasing number of…”
Get full text

Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications by Bullock, William H, Magnuson, Steven R, Choi, Soongyu, Gunn, David E, Rudolph, Joachim

“…The worldwide population afflicted with diabetes is growing at an epidemic rate. There are almost five times the number of people suffering from this disease…”
Get more information

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties by Sullivan, J P, Donnelly-Roberts, D, Briggs, C A, Anderson, D J, Gopalakrishnan, M, Xue, I C, Piattoni-Kaplan, M, Molinari, E, Campbell, J E, McKenna, D G, Gunn, D E, Lin, N H, Ryther, K B, He, Y, Holladay, M W, Wonnacott, S, Williams, M, Arneric, S P

“…Accumulating preclinical and clinical evidence data suggests that compounds that selectively activate neuronal nicotinic acetylcholine receptor (nAChR)…”
Get more information

Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Basha, Anwer, Craig, Richard A, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…Symmetrical bis(quinolylmethoxyphenyl)alkylcarboxylic acids were investigated as inhibitors of leukotriene biosynthesis and…”
Get full text

Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic Acids as Leukotriene Biosynthesis Inhibitors by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Woods, Keith W, Gane, Todd, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…A novel series of heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids was studied as leukotriene biosynthesis inhibitors. A hypothesis of…”
Get full text

Structure−Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine (ABT-089):  An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties by Lin, Nan-Horng, Gunn, David E, Ryther, Keith B, Garvey, David S, Donnelly-Roberts, Diana L, Decker, Michael W, Brioni, Jorge D, Buckley, Michael J, Rodrigues, A. David, Marsh, Kennan G, Anderson, David J, Buccafusco, Jerry J, Prendergast, Mark A, Sullivan, James P, Williams, Michael, Arneric, Stephen P, Holladay, Mark W

“…2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine, ABT-089 (S-4), a member of the 3-pyridyl ether class of nicotinic acetylcholine receptor (nAChR) ligands, shows…”
Get full text

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework by Lin, Nan-Horng, Abreo, Melwyn A., Gunn, David E., Lebold, Suzanne A., Lee, Edmund L., Wasicak, James T., Hettinger, Ann-Marie, Daanen, Jerome F., Garvey, David S., Campbell, Jeffrey E., Sullivan, James P., Williams, Michael, Arneric, Stephen P.

“…Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited K i values ranging from 0.15 to > 10,000 nM…”
Get full text

2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands by Elliott, Richard L., Kopecka, Hana, Gunn, David E., Lin, Nan-Horng, Garvey, David S., Ryther, Keith B., Holladay, Mark W., Anderson, David J., Campbell, Jeffrey E., Sullivan, James P., Buckley, Michael J., Gunther, Karen L., O'Neill, Alyssa B., Decker, Michael W., Arnerić, Stephen P.

“…A series of 2-(aryloxymethyl) azetidine and pyrrolidine nAChR ligands in which the 3-pyridyl moiety of a previously described series 1 was replaced by a…”
Get full text

Synthesis and resolution of 2-(cyclohexyl-4-(2-quinolylmethoxy)phenyl)methoxyiminopropionic acid, leukotriene biosynthesis inhibitors by Kolasa, Teodozyj, Gunn, David E., Stewart, Andrew O., Brooks, Clint D.W.

“…The synthesis and resolution of 2-(E)-(cyclohexyl-4-(2-quinolylmethoxy)-phenyl)methoxyiminopropionic acid 1, a potent leukotriene biosynthesis inhibitor is…”
Get full text