Search Results - "Gunjan, Akash"

The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague–Dawley rats by Hollis, Fiona, Wang, Hui, Dietz, David, Gunjan, Akash, Kabbaj, Mohamed

“…Rationale Social stress has been linked to several neuropsychiatric diseases, including depression, which is a debilitating disease that has genetic,…”
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Visualizing the triheteromeric N-methyl-D-aspartate receptor subunit composition by Beesley, Stephen, Gunjan, Akash, Kumar, Sanjay S

“…N-methyl-D-aspartate receptors (NMDARs) are one of three ligand-gated ionotropic channels that transduce the effects of neurotransmitter glutamate at…”
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Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae by Singh, Rakesh Kumar, Gonzalez, Melanie, Kabbaj, Marie-Helene Miquel, Gunjan, Akash

“…Core histone proteins are essential for packaging the genomic DNA into chromatin in all eukaryotes. Since multiple genes encode these histone proteins, there…”
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Histone tyrosine phosphorylation comes of age by Singh, Rakesh Kumar, Gunjan, Akash

“…Histones were discovered over a century ago and have since been found to be the most extensively posttranslationally modified proteins, although tyrosine…”
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Dynamic binding of histone H1 to chromatin in living cells by Misteli, Tom, Gunjan, Akash, Hock, Robert, Bustin, Michael, Brown, David T

“…The linker histone H1 is believed to be involved in chromatin organization by stabilizing higher-order chromatin structure. Histone H1 is generally viewed as a…”
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Regulation of histone synthesis and nucleosome assembly by Gunjan, Akash, Paik, Johanna, Verreault, Alain

“…Histone deposition onto nascent DNA is the first step in the process of chromatin assembly during DNA replication. The process of nucleosome assembly…”
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FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1 by Morillo-Huesca, Macarena, Maya, Douglas, Muñoz-Centeno, Mari Cruz, Singh, Rakesh Kumar, Oreal, Vincent, Reddy, Gajjalaiahvari Ugander, Liang, Dun, Géli, Vincent, Gunjan, Akash, Chávez, Sebastián

“…The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which…”
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Erratum to: Singh R.K. and Gunjan A. Histone tyrosine phosphorylation comes of age. Epigenetics 2011; 6:153-60 by Singh, Rakesh Kumar, Gunjan, Akash

“…We recently noticed that there is a major error in Figure 1 of our review published in Epignetics 2010, Volume 6, Issue 2. During the preparation of the…”
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Excess histone levels mediate cytotoxicity via multiple mechanisms by Singh, Rakesh Kumar, Liang, Dun, Gajjalaiahvari, Ugander Reddy, Kabbaj, Marie-Helene Miquel, Paik, Johanna, Gunjan, Akash

“…The accumulation of excess histone proteins in cells has deleterious consequences such as genomic instability in the form of excessive chromosome loss,…”
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Effects of H1 Histone Variant Overexpression on Chromatin Structure by Gunjan, A, Alexander, B T, Sittman, D B, Brown, D T

“…The importance of histone H1 heterogeneity and total H1 stoichiometry in chromatin has been enigmatic. Here we report a detailed characterization of the…”
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Histone variants: The unsung guardians of the genome by Phillips, Ernest O.N., Gunjan, Akash

“…Histones H2A, H2B, H3, H4 and H1 are highly conserved, positively charged proteins which form a disc-shaped protein core around which genomic DNA is wrapped to…”
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Core Histone Acetylation Is Regulated by Linker Histone Stoichiometry in Vivo by Gunjan, Akash, Sittman, Donald B., Brown, David T.

“…We investigated the relationship between linker histone stoichiometry and the acetylation of core histones in vivo. Exponentially growing cell lines induced to…”
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Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis by Kabbaj, Marie-Helene Miquel, Singh, Rakesh Kumar, Gunjan, Akash, Paik, Johanna

“…Non-chromatin associated histones are unstable in budding yeast. Tyrosine phosphorylation of histone H3 followed by subsequent ubiquitylation by the ubiquitin…”
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A Rad53 Kinase-Dependent Surveillance Mechanism that Regulates Histone Protein Levels in S. cerevisiae by Gunjan, Akash, Verreault, Alain

“…Rad53 and Mec1 are protein kinases required for DNA replication and recovery from DNA damage in Saccharomyces cerevisiae. Here, we show that rad53, but not…”
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Colocalization of distinct NMDA receptor subtypes at excitatory synapses in the entorhinal cortex by Beesley, Stephen, Sullenberger, Thomas, Pilli, Jyotsna, Abbasi, Saad, Gunjan, Akash, Kumar, Sanjay S

“…The subunit composition of N-methyl-d-aspartate receptors (NMDARs) at synaptic inputs onto a neuron can either vary or be uniform depending on the type of…”
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Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication by Hammack, Christy, Ogden, Sarah C, Madden, Jr, Joseph C, Medina, Angelica, Xu, Chongchong, Phillips, Ernest, Son, Yuna, Cone, Allaura, Giovinazzi, Serena, Didier, Ruth A, Gilbert, David M, Song, Hongjun, Ming, Guoli, Wen, Zhexing, Brinton, Margo A, Gunjan, Akash, Tang, Hengli

“…Zika virus (ZIKV) infection attenuates the growth of human neural progenitor cells (hNPCs). As these hNPCs generate the cortical neurons during early brain…”
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Treatment of keloids with a single dose of low-energy superficial X-ray radiation to prevent recurrence after surgical excision: An in vitro and in vivo study by Son, Yuna, Phillips, Ernest Owen Nicandro, Price, Kristin Magrini, Rosenberg, Laurence Zalmon, Stefanovic, Branko, Wolfe, Christopher Michael, Shaath, Tarek Samir, Om, Amit, Cohen, George Franklin, Gunjan, Akash

“…Although keloids have been empirically treated with steroids and radiation, evidence-based radiation parameters for keloid therapy are lacking. To determine…”
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Preparation of Cell Extracts by Cryogrinding in an Automated Freezer Mill by Phillips, Ernest O N, Giovinazzi, Serena, Menz, Sarah L, Son, Yuna, Gunjan, Akash

“…The ease of genetic manipulation and the strong evolutionary conservation of eukaryotic cellular machinery in the budding yeast Saccharomyces cerevisiae has…”
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Generation and management of excess histones during the cell cycle by Singh, Rakesh Kumar, Paik, Johanna, Gunjan, Akash

“…Histones are essential proteins that package the DNA in all eukaryotes into chromosomes. However, histones can accumulate upon a decrease in DNA synthesis that…”
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Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway by Liang, Dun, Burkhart, Sarah Lyn, Singh, Rakesh Kumar, Kabbaj, Marie-Helene Miquel, Gunjan, Akash

“…In eukaryotes, multiple genes encode histone proteins that package genomic deoxyribonucleic acid (DNA) and regulate its accessibility. Because of their…”
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