Severity of minor physical anomalies as a possible trait marker in schizophrenia/Sizofrenide olasi bir isaretleyici olarak minor fiziksel anomalilerin siddeti

Objective: To investigate, 1- whether siblings of patients with schizophrenia had higher minor physical anomalies (MPAs) than controls, 2- whether symptom ratings were associated with MPAs in patients with schizophrenia. Methods: The sample included 38 subjects with schizophrenia, their 34 unaffecte...

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Bibliographic Details
Published in:	Noro-Psikiyatri Arsivi Vol. 49; no. 3; p. 188
Main Authors:	Boztas, Mehmet Hamid, Guney, Ekrem, Arisoy, Ozden, Sercan, Mustafa, Ensari, Hulya
Format:	Journal Article
Language:	English
Published:	Ankara AVES 01-09-2012 BAYT Ltd. Co
Subjects:	Depression, Mental Diagnosis Head injuries Schizophrenia
Online Access:	Get full text
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Summary:	Objective: To investigate, 1- whether siblings of patients with schizophrenia had higher minor physical anomalies (MPAs) than controls, 2- whether symptom ratings were associated with MPAs in patients with schizophrenia. Methods: The sample included 38 subjects with schizophrenia, their 34 unaffected siblings and 38 healthy controls. Semi-structured interview was used to make schizophrenia diagnosis and screen other DSM-IV disorders. Patients with substance abuse, affective psychosis and head trauma were excluded from the study. Siblings and healthy controls with DSM-IV Axis I diagnosis were excluded from the study. Positive and Negative Symptoms Scale (PANNS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) to evaluate psychotic, depressive and anxiety symptoms, respectively. Waldrop scale was used to assess MPAs. Results: PANNS, BDI, BAI and Waldrop scores were significantly higher in the schizophrenia group when compared with the siblings and the healthy control group. Waldrop score was higher in the siblings than healthy controls. PANNS, BDI and BAI scores were not significantly different in this two groups. PANNS, BDI and BAI scores were significantly correlated in the healthy controls but not in the schizophrenia and the siblings group. Discussion: In a more homogeneous sample consisting only of unaffected siblings; our results showed that patients with schizophrenia had higher MPAs then their siblings who had higher MPAs then healthy controls. These results argue in favor of MPAs as risk markers for schizophrenia. (Archives of Neuropsychiatry-2012; 49:188-191) Key words: Schizophrenia, neurodevelopment, minor physical anomalies Amac: Calismanin iki ana amaci vardir. Ilki sizofreni hastalarinin kardeslerinde saglikli kontrollere gore minor fiziksel anomalilerin (MFA) daha fazla olup olmadigini arastirmak ikincisi de sizofreni hastalarinda belirti siddetiyle MFA arasinda iliski olup olmadigini incelemektir. Yontem: Calisma orneklemi 38 sizofreni hastasi, 38 saglikli kontrol ve 34 sizofreni hastasinin saglikli kardeslerinden olusmaktadir. Sizofreni tanisi konmasinda ve diger hastalik taramalarinda DSM IV e gore yari yapilandirilmis gorusme yontemi kullanilmistir (SCID). Sizofreni hastalarinda kafa travmasi, madde kotuye kullanimi ve afektif psikoz varsa calismadan dislanmistir. Kardeslerde ve saglikli kontrollerde herhangi bir DSM IV Tanimlanmis bozukluk varsa calisma disi birakilmistir. Psikoz, depresyon ve kaygi bulgulari icin sirasiyla Pozitif ve Negatif Semptom Skalasi (PANNS), Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) kullanilmistir. MFA degerlendirilmesi icin Waldrop olcegi kullanilmistir. Bulgular: Sizofreni hastalarinda PANSS, BDI, BAI ve Waldrop puanlari kardesler ve saglikli kontrollere gore istatistiksel olarak anlamli duzeyde yuksektir. Waldrop puanlari kardeslerde saglikli kontrollere gore anlamli olarak daha yuksektir. PANSS, BDI, BAI puanlari kardesler ve saglikli kontrollerde farkli bulunmamistir. PANSS, BDI, BAI puanlari saglikli kontrollerde korelasyon gosterirken sizofreni hastalarinda ve kardeslerinde korelasyon gostermemistir. Sonuc: Sadece kardesleri icermesi acisindan homojen bir birinci derece akraba grubunu kapsayan orneklemde, sizofreni hastalarinda minor fiziksel anomaliler kardeslerinden ve kardeslerde de saglikli kontrollerden daha fazla oldugu saptanmistir. Sonuclarimiz MFA derecesinde yuksekligin sizofreni icin bir isaretleyici olabilecegine destek teskil etmektedir. (Noropsikiyatri Arsivi 2012; 49:188-191) Anahtar kelimeler: Sizofreni, norogelisim, minor fiziksel anomaliler
ISSN:	1300-0667 1309-4866
DOI:	10.4274/npa.y6148