Search Results - "Gunduz, Mithat"

In vitro ocular metabolism and bioactivation of ketoconazole in rat, rabbit and human by Cirello, Amanda L., Dumouchel, Jennifer L., Gunduz, Mithat, Dunne, Christine E., Argikar, Upendra A.

“…Oral ketoconazole is clinically administered for treatment of severe cases for fungal keratitis. Pharmacodynamics and efficacy of oral and topical (ocular)…”
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Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 1: Volume of Distribution at Steady State by Lombardo, Franco, Waters, Nigel J., Argikar, Upendra A., Dennehy, Michelle K., Zhan, Jenny, Gunduz, Mithat, Harriman, Shawn P., Berellini, Giuliano, Rajlic, Ivana Liric, Obach, R. Scott

“…The authors present a comprehensive analysis on the estimation of volume of distribution at steady state (VDss) in human based on rat, dog, and monkey data on…”
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Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance by Lombardo, Franco, Waters, Nigel J., Argikar, Upendra A., Dennehy, Michelle K., Zhan, Jenny, Gunduz, Mithat, Harriman, Shawn P., Berellini, Giuliano, Liric Rajlic, Ivana, Obach, R. Scott

“…A comprehensive analysis on the prediction of human clearance based on intravenous pharmacokinetic data from rat, dog, and monkey for approximately 400…”
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In vitro investigation of catabolism and metabolism of antibody drug conjugates (ADCS) by Gunduz, Mithat, Cirello, Amanda L., Dumouchel, Jennifer L., Hainzl, Dominik, D'Alessio, Tony, Bialucha, Carl, Capka, Vladimir, Argikar, Upendra A.

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Using a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange Risk by SHAFFER, Christopher L, GUNDUZ, Mithat, THORNBURGH, Bruce A, FATE, Gwendolyn D

“…The metabolism and excretion of N -(3 R )-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3- c ]pyridine-5-carboxamide (1), an agonist of the α 7 nicotinic…”
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New Perspectives on Acyl Glucuronide Risk Assessment in Drug Discovery: Investigation of In vitro Stability, In situ Reactivity, and Bioactivation by Gunduz, Mithat, Argikar, Upendra A, Cirello, Amanda L, Dumouchel, Jennifer L

“…Acyl glucuronides of xenobiotics have been a subject of wide interest from the pharmaceutical industry with respect to biochemical reactivity, hepatic…”
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BIOTRANSFORMATION OF A GABAA RECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUE N-CARBAMOYL METABOLITES by SHAFFER, Christopher L, GUNDUZ, Mithat, O'CONNELL, Thomas N, OBACH, R. Scott, YEE, Shiyin

“…The absorption, metabolism, and excretion of N -[3-fluoro-4-[2-(propylamino)ethoxy]phenyl]-4,5,6,7-tetrahydro-4-oxo-1 H -indole-3-carboxamide…”
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Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations by He, Minxia Michelle, Zhu, Sean Xiaochun, Cannon, Joe R., Christensen, Jesper Kammersgaard, Duggal, Ruchia, Gunduz, Mithat, Hilgendorf, Constanze, Hughes, Adam, Kekessie, Ivy, Kullmann, Maximilian, Leung, Dennis, Terjung, Carsten, Wang, Kai, Wesche, Frank

“…Therapeutic peptides (TPeps) have expanded from the initial endogenous peptides to complex modified peptides through medicinal chemistry efforts for almost a…”
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Metabolism and excretion of therapeutic peptides: current industry practices and recommendations by He, Minxia, Zhu, Xiaochun (Sean), Cannon, Joe, Christensen, Jesper, Duggal, Ruchia, Gunduz, Mithat, Hilgendorf, Constanze, Hughes, Adam, Kekessie, Ivy, Leung, Dennis, Terjung, Carsten, Wang, Kai

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Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation by Pearson, David, Jin, Yi, Romeo, Andrea, Birlinger, Bertrand-Luc, Schiller, Hilmar, Ji, Yan, Gunduz, Mithat, Baldoni, Daniela, Walles, Markus

“…LSZ102 is an orally bioavailable selective oestrogen receptor degrader in clinical development for the treatment of breast cancer. Preclinical studies showed…”
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Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route by Dumouchel, Jennifer L, Chemuturi, Nagendra, Milton, Mark N, Camenisch, Gian, Chastain, James, Walles, Markus, Sasseville, Vito, Gunduz, Mithat, Iyer, Ganesh R, Argikar, Upendra A

“…The eye is a complex organ with a series of anatomic barriers that provide protection from physical and chemical injury while maintaining homeostasis and…”
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Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? by Argikar, Upendra A, Dumouchel, Jennifer L, Kramlinger, Valerie M, Cirello, Amanda L, Gunduz, Mithat, Dunne, Christine E, Sohal, Bindi

“…The liver is known to be the principal site of drug metabolism. Depending on the route of administration, especially in cases of topical and local delivery,…”
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Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways by Argikar, Upendra A, Dumouchel, Jennifer L, Dunne, Christine E, Saran, Chitra, Cirello, Amanda L, Gunduz, Mithat

“…Although ocular transport and delivery have been well studied, metabolism in the eye is not well documented, even for clinically available medications such as…”
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Identification of a Novel N-Carbamoyl Glucuronide: In Vitro, In Vivo, and Mechanistic Studies by GUNDUZ, Mithat, ARGIKAR, Upendra A, BAESCHLIN, Daniel, FERREIRA, Suzie, HOSAGRAHARA, Vinayak, HARRIMAN, Shawn

“…1-[4-Aminomethyl-4-(3-chlorophenyl)-cyclohexyl]-tetrahydro-pyrimidin- 2-one, 1, was developed as an inhibitor of dipeptidyl peptidase-4 enzyme…”
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Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate by Gunduz, Mithat, Argikar, Upendra A, Kamel, Amin, Colizza, Kevin, Bushee, Jennifer L, Cirello, Amanda, Lombardo, Franco, Harriman, Shawn

“…In vitro metabolite identification and GSH trapping studies in human liver microsomes were conducted to understand the bioactivation potential of compound 1…”
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In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase by Kamel, Amin, Colizza, Kevin, Gunduz, Mithat, Harriman, Shawn, Obach, R. Scott

“…Oxidative deamination of the GABAA partial agonist CP-409,092 and sumatriptan represents a major metabolic pathway and seems to play an important role for the…”
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Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans by Shaffer, Christopher L, Gunduz, Mithat, Scialis, Renato J, Fang, Annie F

“…The metabolism and disposition of N-(3R)-1-azabicyclo[2.2.2]oct-3-ylfuro[2,3-c]pyridine-5-carboxamide (1), an alpha(7) nicotinic acetylcholinergic receptor…”
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Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition by Christopher L. Shaffer, Mithat Gunduz, Tim F. Ryder, Thomas N. O'Connell

“…The metabolism and disposition of (1 R ,5 S )-2,3,4,5-tetrahydro-7-(trifluoromethyl)-1,5-methano-1 H -3-benzazepine (1), an α 4 β 2 nicotinic acetylcholine…”
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Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition by SHAFFER, Christopher L, GUNDUZ, Mithat, RYDER, Tim F, O'CONNELL, Thomas N

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Metabolism and disposition of a selective α7 nicotinic acetylcholine receptor agonist in humans by SHAFFER, Christopher L, GUNDUZ, Mithat, SCIALIS, Renato J, FANG, Annie F

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