Search Results - "Gundersen, G."

Nuclear Positioning by Gundersen, Gregg G., Worman, Howard J.

“…The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet during cell division, migration, and differentiation, it…”
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Accessorizing and anchoring the LINC complex for multifunctionality by Chang, Wakam, Worman, Howard J, Gundersen, Gregg G

“…The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1…”
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Beyond polymer polarity: how the cytoskeleton builds a polarized cell by Li, Rong, Gundersen, Gregg G

“…Key Points Actin and microtubules are dynamic polar polymers that are well suited for providing the structural basis for cell polarity. Nucleation and plus-end…”
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Generation of noncentrosomal microtubule arrays by Bartolini, Francesca, Gundersen, Gregg G

“…In most proliferating and migrating animal cells, the centrosome is the main site for microtubule (MT) nucleation and anchoring, leading to the formation of…”
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Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization by Meinke, Peter, Mattioli, Elisabetta, Haque, Farhana, Antoku, Susumu, Columbaro, Marta, Straatman, Kees R, Worman, Howard J, Gundersen, Gregg G, Lattanzi, Giovanna, Wehnert, Manfred, Shackleton, Sue

“…Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as…”
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Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension by Arsenovic, Paul T., Ramachandran, Iswarya, Bathula, Kranthidhar, Zhu, Ruijun, Narang, Jiten D., Noll, Natalie A., Lemmon, Christopher A., Gundersen, Gregg G., Conway, Daniel E.

“…The nucleus of a cell has long been considered to be subject to mechanical force. Despite the observation that mechanical forces affect nuclear geometry and…”
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Fascin Regulates Nuclear Movement and Deformation in Migrating Cells by Jayo, Asier, Malboubi, Majid, Antoku, Susumu, Chang, Wakam, Ortiz-Zapater, Elena, Groen, Christopher, Pfisterer, Karin, Tootle, Tina, Charras, Guillaume, Gundersen, Gregg G., Parsons, Maddy

“…Fascin is an F-actin-bundling protein shown to stabilize filopodia and regulate adhesion dynamics in migrating cells, and its expression is correlated with…”
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Formins and microtubules by Bartolini, F., Gundersen, G.G.

“…Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in…”
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Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase by Gundersen, Gregg G, Ezratty, Ellen J, Partridge, Michael A

“…Imaging studies implicate microtubule targeting of focal adhesions in focal adhesion disassembly, although the molecular mechanism is unknown. Here, we develop…”
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Nuclear Movement Regulated by Cdc42, MRCK, Myosin, and Actin Flow Establishes MTOC Polarization in Migrating Cells by Gomes, Edgar R., Jani, Shantanu, Gundersen, Gregg G.

“…The microtubule-organizing center (MTOC) is reoriented between the nucleus and the leading edge in many migrating cells and contributes to directional…”
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Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells by Ezratty, Ellen J, Bertaux, Claire, Marcantonio, Eugene E, Gundersen, Gregg G

“…Focal adhesion disassembly is regulated by microtubules (MTs) through an unknown mechanism that involves dynamin. To test whether endocytosis may be involved,…”
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Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement by Luxton, G.W. Gant, Gomes, Edgar R, Folker, Eric S, Vintinner, Erin, Gundersen, Gregg G

“…Nuclei move to specific locations to polarize migrating and differentiating cells. Many nuclear movements are microtubule-dependent. However, nuclear movement…”
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Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach by Knudsen, Lars, Weibel, Ewald R, Gundersen, Hans Jorgen G, Weinstein, Felix V, Ochs, Matthias

“…1 Institute of Anatomy, University of Bern, Bern, Switzerland; ; 2 Stereology and Electron Microscopy Research Laboratory, University of Aarhus, Aarhus,…”
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Nuclear positioning in migrating fibroblasts by Zhu, Ruijun, Liu, Chenshu, Gundersen, Gregg G.

“…The positioning and movement of the nucleus has recently emerged as an important aspect of cell migration. Understanding of nuclear positioning and movement…”
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HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection by Sabo, Yosef, Walsh, Derek, Barry, Denis S., Tinaztepe, Sedef, de los Santos, Kenia, Goff, Stephen P., Gundersen, Gregg G., Naghavi, Mojgan H.

“…Stable microtubule (MT) subsets form distinct networks from dynamic MTs and acquire distinguishing posttranslational modifications, notably detyrosination and…”
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Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics by Vahabikashi, Amir, Sivagurunathan, Suganya, Nicdao, Fiona Ann Sadsad, Han, Yu Long, Park, Chan Young, Kittisopikul, Mark, Wong, Xianrong, Tran, Joseph R, Gundersen, Gregg G, Reddy, Karen L, Luxton, G W Gant, Guo, Ming, Fredberg, Jeffrey J, Zheng, Yixian, Adam, Stephen A, Goldman, Robert D

“…The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus…”
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Are non‐invasive fibrosis markers for chronic hepatitis B reliable in sub‐Saharan Africa? by Desalegn, Hailemichael, Aberra, Hanna, Berhe, Nega, Gundersen, Svein G., Johannessen, Asgeir

“…Background In the absence of liver biopsy, the World Health Organization recommends non‐invasive tests, such as aspartate aminotransferase to platelet ratio…”
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Orientation and function of the nuclear–centrosomal axis during cell migration by Luxton, GW Gant, Gundersen, Gregg G

“…Highlights ► Anterior NC axis orientation is observed in many, but not all migrating cells. ► MT organization, vesicle trafficking and nuclear movement are NC…”
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Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling by Palazzo, Alexander F., Eng, Christina H., Schlaepfer, David D., Marcantonio, Eugene E., Gundersen, Gregg G.

“…Microtubule (MT) stabilization is regulated by the small guanosine triphosphate (GTP)-binding protein Rho and its effector, mammalian homolog of Diaphanous…”
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Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1–42 synaptotoxicity by Qu, Xiaoyi, Yuan, Feng Ning, Corona, Carlo, Pasini, Silvia, Pero, Maria Elena, Gundersen, Gregg G., Shelanski, Michael L., Bartolini, Francesca

“…Oligomeric Amyloid β1–42 (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between…”
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