Search Results - "Gundelach, Justin H."

Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme by Wang, Lin, Gundelach, Justin H, Bram, Richard J

“…Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved…”
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ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas by Grausam, Katie B, Dooyema, Samuel D R, Bihannic, Laure, Premathilake, Hasitha, Morrissy, A Sorana, Forget, Antoine, Schaefer, Amanda M, Gundelach, Justin H, Macura, Slobodan, Maher, Diane M, Wang, Xin, Heglin, Alex H, Ge, Xijin, Zeng, Erliang, Puget, Stephanie, Chandrasekar, Indra, Surendran, Kameswaran, Bram, Richard J, Schüller, Ulrich, Talyor, Michael D, Ayrault, Olivier, Zhao, Haotian

“…Medulloblastoma arising from the cerebellum is the most common pediatric brain malignancy, with leptomeningeal metastases often present at diagnosis and…”
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Clinician Perspectives on Clinical Decision Support for Familial Hypercholesterolemia by Bangash, Hana, Elsekaily, Omar, Saadatagah, Seyedmohammad, Sutton, Joseph, Johnsen, Paul, Gundelach, Justin H, Kamzabek, Arailym, Freimuth, Robert, Caraballo, Pedro J, Kullo, Iftikhar J

“…Familial Hypercholesterolemia (FH) is underdiagnosed in the United States. Clinical decision support (CDS) could increase FH detection once implemented in…”
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Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels by Bangash, Hana, Saadatagah, Seyedmohammad, Naderian, Mohammadreza, Hamed, Marwan E., Alhalabi, Lubna, Sherafati, Alborz, Sutton, Joseph, Elsekaily, Omar, Mir, Ali, Gundelach, Justin H., Gibbons, Daniel, Johnsen, Paul, Wood-Wentz, Christina M., Smith, Carin Y., Caraballo, Pedro J., Bailey, Kent R., Kullo, Iftikhar J.

“…Severe hypercholesterolemia/possible familial hypercholesterolemia (FH) is relatively common but underdiagnosed and undertreated. We investigated whether…”
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Web-Based Tool (FH Family Share) to Increase Uptake of Cascade Testing for Familial Hypercholesterolemia: Development and Evaluation by Bangash, Hana, Makkawy, Ahmed, Gundelach, Justin H, Miller, Alexandra A, Jacobson, Kimberly A, Kullo, Iftikhar J

“…Familial hypercholesterolemia, a prevalent genetic disorder, remains significantly underdiagnosed in the United States. Cascade testing, wherein individuals…”
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Inhibition of RAS-Mediated Transformation and Tumorigenesis by Targeting the Downstream E3 Ubiquitin Ligase Seven in Absentia Homologue by SCHMIDT, Rebecca L, CHEOL HONG PARK, AHMED, Atique U, GUNDELACH, Justin H, REED, Nanette R, SHEN CHENG, KNUDSEN, Bruce E, TANG, Amy H

“…Constitutively active RAS small GTPases promote the genesis of human cancers. An important goal in cancer biology is to identify means of countervailing…”
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Phase I trial of sargramostim/pelareorep therapy in pediatric patients with recurrent or refractory high-grade brain tumors by Schuelke, Matthew R, Gundelach, Justin H, Coffey, Matt, West, Emma, Scott, Karen, Johnson, Derek R, Samson, Adel, Melcher, Alan, Vile, Richard G, Bram, Richard J

“…Abstract Background Brain tumors are the leading cause of cancer death for pediatric patients. Pelareorep, an immunomodulatory oncolytic reovirus, has…”
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Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype by Sarró, Eduard, Durán, Mónica, Rico, Ana, Bou-Teen, Diana, Fernández-Majada, Vanesa, Croatt, Anthony J, Nath, Karl A, Salcedo, Maria Teresa, Gundelach, Justin H, Batlle, Daniel, Bram, Richard J, Meseguer, Anna

“…Abstract Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition (pEMT),…”
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An Implementation Science Framework to Develop a Clinical Decision Support Tool for Familial Hypercholesterolemia by Bangash, Hana, Pencille, Laurie, Gundelach, Justin H, Makkawy, Ahmed, Sutton, Joseph, Makkawy, Lenae, Dikilitas, Ozan, Kopecky, Stephen, Freimuth, Robert, Caraballo, Pedro J, Kullo, Iftikhar J

“…Electronic health record (EHR)-based clinical decision support (CDS) can address the low awareness and undertreatment of familial hypercholesterolemia (FH), a…”
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The anticancer drug Dp44mT inhibits T‐cell activation and CD25 through a copper‐dependent mechanism by Gundelach, Justin H., Madhavan, Ajay A., Wettstein, Peter J., Bram, Richard J.

“…The di‐2‐pyridylketone thiosemicarbazone Dp44mT is a metal‐chelating compound that has been demonstrated to have potent activity as an anticancer agent. Here…”
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Essential role for CAML in follicular B cell survival and homeostasis by Zane, Nicholas A, Gundelach, Justin H, Lindquist, Lonn D, Bram, Richard J

“…Calcium-modulating cyclophilin ligand (CAML) is a ubiquitously expressed protein that is important during thymopoiesis. However, whether it serves a function…”
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Deploying Clinical Decision Support for Familial Hypercholesterolemia by Bangash, Hana, Sutton, Joseph, Gundelach, Justin H., Pencille, Laurie, Makkawy, Ahmed, Elsekaily, Omar, Dikilitas, Ozan, Mir, Ali, Freimuth, Robert, Caraballo, Pedro J., Kullo, Iftikhar J.

“…Abstract Objective  Familial hypercholesterolemia (FH), a prevalent genomic disorder that increases risk of coronary heart disease, remains significantly…”
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AN ELECTRONIC HEALTH RECORD-BASED ALGORITHM TO ALERT CLINICIANS TO THE PRESENCE OF POSSIBLE FAMILIAL HYPERCHOLESTEROLEMIA by Bangash, Hana, Sutton, Joseph, Elsekaily, Omar, Dikilitas, Ozan, Gundelach, Justin H., Kopecky, Stephen, Freimuth, Robert, Caraballo, Pedro, Kullo, Iftikhar J.

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Evaluation of the portability of computable phenotypes with natural language processing in the eMERGE network by Pacheco, Jennifer A., Rasmussen, Luke V., Wiley, Ken, Person, Thomas Nate, Cronkite, David J., Sohn, Sunghwan, Murphy, Shawn, Gundelach, Justin H., Gainer, Vivian, Castro, Victor M., Liu, Cong, Mentch, Frank, Lingren, Todd, Sundaresan, Agnes S., Eickelberg, Garrett, Willis, Valerie, Furmanchuk, Al’ona, Patel, Roshan, Carrell, David S., Deng, Yu, Walton, Nephi, Satterfield, Benjamin A., Kullo, Iftikhar J., Dikilitas, Ozan, Smith, Joshua C., Peterson, Josh F., Shang, Ning, Kiryluk, Krzysztof, Ni, Yizhao, Li, Yikuan, Nadkarni, Girish N., Rosenthal, Elisabeth A., Walunas, Theresa L., Williams, Marc S., Karlson, Elizabeth W., Linder, Jodell E., Luo, Yuan, Weng, Chunhua, Wei, WeiQi

“…The electronic Medical Records and Genomics (eMERGE) Network assessed the feasibility of deploying portable phenotype rule-based algorithms with natural…”
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