Search Results - "Gunby, Rosalind H."

PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State by Green, Brenda J., Marazzini, Margherita, Hershey, Ben, Fardin, Amir, Li, Qingsen, Wang, Zongjie, Giangreco, Giovanni, Pisati, Federica, Marchesi, Stefano, Disanza, Andrea, Frittoli, Emanuela, Martini, Emanuele, Magni, Serena, Beznoussenko, Galina V., Vernieri, Claudio, Lobefaro, Riccardo, Parazzoli, Dario, Maiuri, Paolo, Havas, Kristina, Labib, Mahmoud, Sigismund, Sara, Di Fiore, Pier Paolo, Gunby, Rosalind H., Kelley, Shana O., Scita, Giorgio

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Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias by Gambacorti-Passerini, Carlo B, Gunby, Rosalind H, Piazza, Rocco, Galietta, Annamaria, Rostagno, Roberta, Scapozza, Leonardo

“…Imatinib (STI571 or CGP57148B) is an innovative treatment for tumours with a constitutively activated form of c-ABL, c-KIT, or PDGFR. Such tumours include…”
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Characterization of Some Molecular Mechanisms Governing Autoactivation of the Catalytic Domain of the Anaplastic Lymphoma Kinase by Tartari, Carmen J., Gunby, Rosalind H., Coluccia, Addolorata M.L., Sottocornola, Roberta, Cimbro, Barbara, Scapozza, Leonardo, Donella-Deana, Arianna, Pinna, Lorenzo A., Gambacorti-Passerini, Carlo

“…NPM/ALK is an oncogenic fusion protein expressed in ∼50% of anaplastic large cell lymphoma cases. It derives from the t(2;5)(p23;q35) chromosomal translocation…”
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NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma by Galietta, Annamaria, Gunby, Rosalind H., Redaelli, Sara, Stano, Paola, Carniti, Cristiana, Bachi, Angela, Tucker, Philip W., Tartari, Carmen J., Huang, Ching-Jung, Colombo, Emanuela, Pulford, Karen, Puttini, Miriam, Piazza, Rocco G., Ruchatz, Holger, Villa, Antonello, Donella-Deana, Arianna, Marin, Oriano, Perrotti, Danilo, Gambacorti-Passerini, Carlo

“…The oncogenic fusion tyrosine kinase nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) induces cellular transformation in anaplastic large-cell lymphomas…”
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PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State by Green, Brenda J., Marazzini, Margherita, Hershey, Ben, Fardin, Amir, Li, Qingsen, Wang, Zongjie, Giangreco, Giovanni, Pisati, Federica, Marchesi, Stefano, Disanza, Andrea, Frittoli, Emanuela, Martini, Emanuele, Magni, Serena, Beznoussenko, Galina V., Vernieri, Claudio, Lobefaro, Riccardo, Parazzoli, Dario, Maiuri, Paolo, Havas, Kristina, Labib, Mahmoud, Sigismund, Sara, Fiore, Pier Paolo Di, Gunby, Rosalind H., Kelley, Shana O., Scita, Giorgio

“…Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and…”
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Unique Substrate Specificity of Anaplastic Lymphoma Kinase (ALK):  Development of Phosphoacceptor Peptides for the Assay of ALK Activity by Donella-Deana, Arianna, Marin, Oriano, Cesaro, Luca, Gunby, Rosalind H, Ferrarese, Anna, Coluccia, Addolorata M. L, Tartari, Carmen J, Mologni, Luca, Scapozza, Leonardo, Gambacorti-Passerini, Carlo, Pinna, Lorenzo A

“…The anaplastic lymphoma kinase (ALK), whose constitutively active fusion proteins are responsible for 5−10% of non-Hodgkin's lymphomas, shares with the other…”
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A Mechanistic Design Principle for Protein Tyrosine Kinase Sensors:  Application to a Validated Cancer Target by Wakata, Aya, Cahill, Sean M, Blumenstein, Michael, Gunby, Rosalind H, Jockusch, Steffen, Marti, Angel A, Cimbro, Barbara, Gambacorti-Passerini, Carlo, Donella-Deana, Arianna, Pinna, Lorenzo A, Turro, Nicholas J, Lawrence, David S

“…A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein…”
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Characterization of compound 584, an Abl kinase inhibitor with lasting effects by Puttini, Miriam, Redaelli, Sara, Moretti, Loris, Brussolo, Stefania, Gunby, Rosalind H, Mologni, Luca, Marchesi, Edoardo, Cleris, Loredana, Donella-Deana, Arianna, Drueckes, Peter, Sala, Elisa, Lucchini, Vittorio, Kubbutat, Michael, Formelli, Franca, Zambon, Alfonso, Scapozza, Leonardo, Gambacorti-Passerini, Carlo

“…1 Department of Clinical Medicine, University of Milano-Bicocca, S. Gerardo Hospital, Monza, Italy 2 Pharmaceutical Biochemistry Group, School of…”
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Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers by Brunet, C L, Gunby, R H, Benson, R S, Hickman, J A, Watson, A J, Brady, G

“…Kinetic analysis of dexamethasone-induced apoptosis in the human lymphoblastoid cell line CCRF CEM C7A has revealed a point when cells, morphologically…”
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Structural Insights into the ATP Binding Pocket of the Anaplastic Lymphoma Kinase by Site-Directed Mutagenesis, Inhibitor Binding Analysis, and Homology Modeling by Gunby, Rosalind H, Ahmed, Shaheen, Sottocornola, Roberta, Gasser, Marc, Redaelli, Sara, Mologni, Luca, Tartari, Carmen J, Belloni, Valentina, Gambacorti-Passerini, Carlo, Scapozza, Leonardo

“…Anaplastic lymphoma kinase (ALK) is a valid target for anticancer therapy; however, potent ALK inhibitors suitable for clinical use are lacking. Because the…”
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Oncogenic fusion tyrosine kinases as molecular targets for anti-cancer therapy by Gunby, Rosalind H, Sala, Elisa, Tartari, Carmen J, Puttini, Miriam, Gambacorti-Passerini, Carlo, Mologni, Luca

“…Deregulated activation of protein tyrosine kinases (PTKs) is a frequent event underlying malignant transformation in many types of cancer. The formation of…”
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Generation and Verification of a Three-Dimensional Model of the ALK Kinase Domain: ALK - a “Supermutant” of Abl by Gunby, Rosalind H., Sottocornola, Roberta, Gasser, Marc, Scapozza, Leonardo, Gambacorti-Passerini, Carlo

“…Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase that plays a key role in oncogenesis in a subset of non-Hodgkin's lymphomas, through the…”
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CD40-Triggered Protein Tyrosine Phosphorylation on Vav and on Phosphatidylinositol 3-Kinase Correlates with Survival of the Ramos–Burkitt Lymphoma B Cell Line by Padmore, Lauren, An, Sungkwan, Gunby, Rosalind H., Kelly, Ken, Radda, George K., Knox, Kirstine A.

“…Signals transduced through CD40 rescue cells of the Ramos–Burkitt lymphoma (Ramos-BL) B cell line from surface immunoglobulin M (sIgM)-triggered growth arrest…”
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