Search Results - "Gunaratne, Jayantha"

The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions by Tan, Benedict, Yatim, Siti Maryam J.M., Peng, Suat, Gunaratne, Jayantha, Hunziker, Walter, Ludwig, Alexander

“…Epithelial apico-basal polarity is established through the asymmetric cortical distribution of the Par, Crumbs and Scribble polarity modules. Apical (Par and…”
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Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness by Manokaran, Gayathri, Finol, Esteban, Wang, Chunling, Gunaratne, Jayantha, Bahl, Justin, Ong, Eugenia Z., Tan, Hwee Cheng, Sessions, October M., Ward, Alex M., Gubler, Duane J., Harris, Eva, Garcia-Blanco, Mariano A., Ooi, Eng Eong

“…The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential…”
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Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions by Baskaran, Yohendran, Tay, Felicia Pei-Ling, Ng, Elsa Yuen Wai, Swa, Claire Lee Foon, Wee, Sheena, Gunaratne, Jayantha, Manser, Edward

“…Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is enriched in cell-cell junctions, we probed the local…”
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The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma by Chang, Cunjie, Rajasekaran, Muthukumar, Qiao, Yiting, Dong, Heng, Wang, Yu, Xia, Hongping, Deivasigamani, Amudha, Wu, Minjie, Sekar, Karthik, Gao, Hengjun, Sun, Mengqing, Niu, Yuqin, Li, Qian, Tao, Lin, Yan, Zhen, Wang, Menglan, Chen, Shasha, Zhao, Shujuan, Chen, Dajing, Li, Lina, Yang, Fan, Gao, Haojin, Chen, Baodong, Su, Ling, Xu, Liang, Chen, Ye, Seshachalam, Veerabrahma Pratap, Chen, Gongxing, Gunaratne, Jayantha, Hong, Wanjin, Shi, Junping, Chen, Gongying, Grierson, David S., Chabot, Benoit, Xie, Tian, Hui, Kam Man, Chen, Jianxiang

“…Deregulation of alternative splicing is implicated as a relevant source of molecular heterogeneity in cancer. However, the targets and intrinsic mechanisms of…”
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Machine Learning-Enhanced Extraction of Biomarkers for High-Grade Serous Ovarian Cancer from Proteomics Data by De Silva, Senuri, Alli-Shaik, Asfa, Gunaratne, Jayantha

“…Comprehensive biomedical proteomic datasets are accumulating exponentially, warranting robust analytics to deconvolute them for identifying novel biological…”
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Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway by Toloczko, Aleksandra, Guo, Fusheng, Yuen, Hiu-Fung, Wen, Qing, Wood, Stephen A, Ong, Yan Shan, Chan, Pei Yi, Shaik, Asfa Alli, Gunaratne, Jayantha, Dunne, Mark J, Hong, Wanjin, Chan, Siew Wee

“…The core LATS kinases of the Hippo tumor suppressor pathway phosphorylate and inhibit the downstream transcriptional co-activators YAP and TAZ, which are…”
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An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma by Chakraborty, Sayan, Lakshmanan, Manikandan, Swa, Hannah L.F., Chen, Jianxiang, Zhang, Xiaoqian, Ong, Yan Shan, Loo, Li Shen, Akıncılar, Semih Can, Gunaratne, Jayantha, Tergaonkar, Vinay, Hui, Kam M., Hong, Wanjin

“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. The identity and role of cell surface molecules driving complex…”
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YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro by Lim, Jia Pei, Shyamasundar, Sukanya, Gunaratne, Jayantha, Scully, Olivia Jane, Matsumoto, Ken, Bay, Boon Huat

“…Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies,…”
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Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB by Chu Yuan Kee, Melissa-Jane, Bharath, Sakshibeedu R., Wee, Sheena, Bowler, Matthew W., Gunaratne, Jayantha, Pan, Shenquan, Zhang, Lianhui, Song, Haiwei

“…Non-ribosomal peptide synthetases (NRPS) are multi-modular/domain enzymes that catalyze the synthesis of bioactive peptides. A crucial step in the process is…”
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Mapping the Interactions of HBV cccDNA with Host Factors by Mohd-Ismail, Nur K, Lim, Zijie, Gunaratne, Jayantha, Tan, Yee-Joo

“…Hepatitis B virus (HBV) infection is a major health problem affecting about 300 million people globally. Although successful administration of a prophylactic…”
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Src activates retrograde membrane traffic through phosphorylation of GBF1 by Chia, Joanne, Wang, Shyi-Chyi, Wee, Sheena, Gill, David James, Tay, Felicia, Kannan, Srinivasaraghavan, Verma, Chandra S, Gunaratne, Jayantha, Bard, Frederic A

“…The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event…”
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Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells by Yang, Bin Xia, EL Farran, Chadi A., Guo, Hong Chao, Yu, Tao, Fang, Hai Tong, Wang, Hao Fei, Schlesinger, Sharon, Seah, Yu Fen Samantha, Goh, Germaine Yen Lin, Neo, Suat Peng, Li, Yinghui, Lorincz, Matthew C., Tergaonkar, Vinay, Lim, Tit-Meng, Chen, Lingyi, Gunaratne, Jayantha, Collins, James J., Goff, Stephen P., Daley, George Q., Li, Hu, Bard, Frederic A., Loh, Yuin-Han

“…Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular…”
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Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy by Khattar, Ekta, Maung, Kyaw Ze Ya, Chew, Chen Li, Ghosh, Arkasubhra, Mok, Michelle Meng Huang, Lee, Pei, Zhang, Jun, Chor, Wei Hong Jeff, Cildir, Gökhan, Wang, Chelsia Qiuxia, Mohd-Ismail, Nur Khairiah, Chin, Desmond Wai Loon, Lee, Soo Chin, Yang, Henry, Shin, Yong-Jae, Nam, Do-Hyun, Chen, Liming, Kumar, Alan Prem, Deng, Lih Wen, Ikawa, Masahito, Gunaratne, Jayantha, Osato, Motomi, Tergaonkar, Vinay

“…Increased levels and non-telomeric roles have been reported for shelterin proteins, including RAP1 in cancers. Herein using Rap1 null mice, we provide the…”
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Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism by Lai, Deborah, Tan, Chye Ling, Gunaratne, Jayantha, Quek, Ling Shih, Nei, Wenlong, Thierry, Françoise, Bellanger, Sophie

“…Papillomavirus E2 proteins are predominantly retained in the nuclei of infected cells, but oncogenic (high-risk) HPV-18 and 16 E2 can shuttle between the host…”
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In vitro cytotoxicity of L-amino acid oxidase from the venom of Crotalus mitchellii pyrrhus by Tan, Kok Keong, Ler, Siok Ghee, Gunaratne, Jayantha, Bay, Boon Huat, Ponnampalam, Gopalakrishnakone

“…L-amino acid oxidase isolated from Crotalus mitchellii pyrrhus (Cmp-LAAO) exhibited cytotoxicity against LNCaP prostate adenocarcinoma cells. The viability of…”
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Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice by Liu, Yiran, Castano, David, Girolamo, Francesco, Trigueros-Motos, Laia, Bae, Han-Gyu, Neo, Suat Peng, Oh, Jeongah, Narayanaswamy, Pradeep, Torta, Federico, Rye, Kerry Anne, Jo, Dong-Gyu, Gunaratne, Jayantha, Jung, Sangyong, Virgintino, Daniela, Singaraja, Roshni R.

“…The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is…”
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Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures by Ward, Alex Michael, Bidet, Katell, Yinglin, Ang, Ler, Siok Ghee, Hogue, Kelly, Blackstock, Walter, Gunaratne, Jayantha, Garcia-Blanco, Mariano A.

“…Dengue virus (DENV) is a rapidly re-emerging flavivirus that causes dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), diseases…”
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Phosphoproteomics Unravel HBV Triggered Rewiring of Host Phosphosignaling Events by Lim, ZiJie, Mohd-Ismail, Nur Khairiah Binte, Png, Evelyn, Sze, Ching Wooen, Lin, Qifeng, Hong, Wanjin, Lim, Seng Gee, Tan, Yee-Joo, Gunaratne, Jayantha

“…Hepatitis B virus (HBV) infection persists as a major global health problem despite the availability of HBV vaccines for disease prevention. However,…”
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Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade by Liu, Zengping, Liow, Sing Shy, Lai, Siew Li, Alli-Shaik, Asfa, Holder, Graham E., Parikh, Bhav Harshad, Krishnakumar, Subramanian, Li, Zibiao, Tan, Mein Jin, Gunaratne, Jayantha, Barathi, Veluchamy Amutha, Hunziker, Walter, Lakshminarayanan, Rajamani, Tan, Clement Woon Teck, Chee, Caroline K., Zhao, Paul, Lingam, Gopal, Loh, Xian Jun, Su, Xinyi

“…Internal-tamponade agents are crucial surgical adjuncts in vitreoretinal surgery. Clinically used endotamponade agents act through buoyancy forces, yet can…”
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Comprehensive Proteomic Characterization Reveals Subclass-Specific Molecular Aberrations within Triple-negative Breast Cancer by Kosok, Max, Alli-Shaik, Asfa, Bay, Boon Huat, Gunaratne, Jayantha

“…Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer lacking targeted therapies. This is attributed to its high heterogeneity…”
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