Search Results - "Gunarathne, Lakmie S"

Cirrhotic portal hypertension: From pathophysiology to novel therapeutics by Gunarathne, Lakmie S, Rajapaksha, Harinda, Shackel, Nicholas, Angus, Peter W, Herath, Chandana B

“…Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirrhosis. Portal hypertension is…”
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Update on New Aspects of the Renin-Angiotensin System in Hepatic Fibrosis and Portal Hypertension: Implications for Novel Therapeutic Options by Rajapaksha, Indu G, Gunarathne, Lakmie S, Angus, Peter W, Herath, Chandana B

“…There is considerable experimental evidence that the renin angiotensin system (RAS) plays a central role in both hepatic fibrogenesis and portal hypertension…”
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Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats by Gunarathne, Lakmie S., Angus, Peter W., Herath, Chandana B.

“…Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The…”
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Liver‐Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug‐Resistant Gene 2‐Knockout Mice by Rajapaksha, Indu G., Gunarathne, Lakmie S., Asadi, Khashayar, Cunningham, Sharon C., Sharland, Alexandra, Alexander, Ian E., Angus, Peter W., Herath, Chandana B.

“…There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a disease that commonly results…”
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Mas‐related G protein‐coupled receptor type D antagonism improves portal hypertension in cirrhotic rats by Gunarathne, Lakmie S., Rajapaksha, Indu G., Casey, Stephen, Qaradakhi, Tawar, Zulli, Anthony, Rajapaksha, Harinda, Trebicka, Jonel, Angus, Peter W., Herath, Chandana B.

“…Splanchnic vasodilatation contributes to the development and aggravation of portal hypertension (PHT). We previously demonstrated that in cirrhosis,…”
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Angiotensin Converting Enzyme‐2 Therapy Improves Liver Fibrosis and Glycemic Control in Diabetic Mice With Fatty Liver by Rajapaksha, Indu G., Gunarathne, Lakmie S., Asadi, Khashayar, Laybutt, Ross, Andrikopoulous, Sof, Alexander, Ian E., Watt, Mathew J., Angus, Peter W., Herath, Chandana B.

“…Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is frequently associated with type 2 diabetes. However, there is…”
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