Search Results - "Gumy, Laura F."

Local mechanisms regulating selective cargo entry and long-range trafficking in axons by Gumy, Laura F, Hoogenraad, Casper C

“…•Axonal cargo entry depends on the presence of multiple subcompartments in the proximal axon.•Local mechanisms along the axon ensure the long-distance…”
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Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization by Gumy, Laura F, Yeo, Giles S H, Tung, Yi-Chun Loraine, Zivraj, Krishna H, Willis, Dianna, Coppola, Giovanni, Lam, Brian Y H, Twiss, Jeffery L, Holt, Christine E, Fawcett, James W

“…mRNAs are transported, localized, and translated in axons of sensory neurons. However, little is known about the full repertoire of transcripts present in…”
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Bicaudal D Family Adaptor Proteins Control the Velocity of Dynein-Based Movements by Schlager, Max A., Serra-Marques, Andrea, Grigoriev, Ilya, Gumy, Laura F., Esteves da Silva, Marta, Wulf, Phebe S., Akhmanova, Anna, Hoogenraad, Casper C.

“…Cargo transport along microtubules is driven by the collective function of microtubule plus- and minus-end-directed motors (kinesins and dyneins). How the…”
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The role of local protein synthesis and degradation in axon regeneration by Gumy, Laura F., Tan, Chin Lik, Fawcett, James W.

“…In axotomised regenerating axons, the first step toward successful regeneration is the formation of a growth cone. This requires a variety of dynamic…”
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Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures by van Spronsen, Myrrhe, van Battum, Eljo Y, Kuijpers, Marijn, Vangoor, Vamshidhar R, Rietman, M Liset, Pothof, Joris, Gumy, Laura F, van Ijcken, Wilfred F J, Akhmanova, Anna, Pasterkamp, R Jeroen, Hoogenraad, Casper C

“…MicroRNAs (miRNAs) are evolutionarily conserved non-coding RNAs of ∼22 nucleotides that regulate gene expression at the level of translation and play vital…”
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Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG by Gumy, Laura F., Bampton, Edward T.W., Tolkovsky, Aviva M.

“…Poorly-controlled hyperglycaemia reduces peripheral nerve regeneration in diabetes through ill-understood mechanisms. Apoptosis is one proposed primary…”
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Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration by Tan, Chin Lik, Andrews, Melissa R, Kwok, Jessica C F, Heintz, Tristan G P, Gumy, Laura F, Fässler, Reinhard, Fawcett, James W

“…Growing and regenerating axons need to interact with the molecules in the extracellular matrix as they traverse through their environment. An important group…”
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Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection by Mayo-Muñoz, David, Smith, Leah M., Garcia-Doval, Carmela, Malone, Lucia M., Harding, Kate R., Jackson, Simon A., Hampton, Hannah G., Fagerlund, Robert D., Gumy, Laura F., Fineran, Peter C.

“…Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple DNA-targeting defenses by protecting their DNA inside a nucleus-like…”
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A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity by Malone, Lucia M., Warring, Suzanne L., Jackson, Simon A., Warnecke, Carolin, Gardner, Paul P., Gumy, Laura F., Fineran, Peter C.

“…CRISPR–Cas systems provide bacteria with adaptive immunity against bacteriophages 1 . However, DNA modification 2 , 3 , the production of anti-CRISPR proteins…”
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Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2 by Ruane, Peter T., Gumy, Laura F., Bola, Becky, Anderson, Beverley, Wozniak, Marcin J., Hoogenraad, Casper C., Allan, Victoria J.

“…Microtubules and their associated proteins (MAPs) underpin the polarity of specialised cells. Adenomatous polyposis coli (APC) is one such MAP with a…”
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MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons by Gumy, Laura F., Katrukha, Eugene A., Grigoriev, Ilya, Jaarsma, Dick, Kapitein, Lukas C., Akhmanova, Anna, Hoogenraad, Casper C.

“…Polarized cargo transport is essential for neuronal function. However, the minimal basic components required for selective cargo sorting and distribution in…”
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New insights into mRNA trafficking in axons by Gumy, Laura F., Katrukha, Eugene A., Kapitein, Lukas C., Hoogenraad, Casper C.

“…ABSTRACT In recent years, it has been demonstrated that mRNAs localize to axons of young and mature central and peripheral nervous system neurons in culture…”
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Inducible Control of mRNA Transport Using Reprogrammable RNA-Binding Proteins by Abil, Zhanar, Gumy, Laura F, Zhao, Huimin, Hoogenraad, Casper C

“…Localization of mRNA is important in a number of cellular processes such as embryogenesis, cellular motility, polarity, and a variety of neurological…”
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The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration by Gumy, Laura F, Chew, Daniel J, Tortosa, Elena, Katrukha, Eugene A, Kapitein, Lukas C, Tolkovsky, Aviva M, Hoogenraad, Casper C, Fawcett, James W

“…Axon regeneration after injury requires the extensive reconstruction, reorganization, and stabilization of the microtubule cytoskeleton in the growth cones…”
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Off the rails: axonal cargoes on the road to nowhere by Gumy, Laura F, Hoogenraad, Casper C

“…Mutations in tubulin genes cause a wide range of neurodevelopmental disorders. Hirokawa and colleagues now report that disease‐associated β‐tubulin mutations…”
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Axonal mRNAs: Characterisation and role in the growth and regeneration of dorsal root ganglion axons and growth cones by Vogelaar, Christina F., Gervasi, Noreen M., Gumy, Laura F., Story, David J., Raha-Chowdhury, Ruma, Leung, Kin-Mei, Holt, Christine E., Fawcett, James W.

“…We have developed a compartmentalised culture model for the purification of axonal mRNA from embryonic, neonatal and adult rat dorsal root ganglia. This mRNA…”
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The role of local protein synthesis and degradation in axon regeneration: Regeneration in the Peripheral Nervous System by GUMY, Laura F, CHIN LIK TAN, FAWCETT, James W

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Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures: e74907 by Spronsen, Myrrhe van, Battum, Eljo Yvan, Kuijpers, Marijn, Vangoor, Vamshidhar R, Rietman, M Liset, Pothof, Joris, Gumy, Laura F, IJcken, F Jvan, Akhmanova, Anna, Pasterkamp, R Jeroen

“…MicroRNAs (miRNAs) are evolutionarily conserved non-coding RNAs of ~22 nucleotides that regulate gene expression at the level of translation and play vital…”
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