Search Results - "Gummadi, Venkateshwar Rao"

Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies by Gummadi, Venkateshwar Rao, Boruah, Anima, Ainan, Bharathi Raja, Vare, Brahma Reddy, Manda, Srinivas, Gondle, Hari Prakash, Kumar, Shiva Nagendra, Mukherjee, Subhendu, Gore, Suraj T, Krishnamurthy, Narasimha Rao, Marappan, Sivapriya, Nayak, Shilpa S, Nellore, Kavitha, Balasubramanian, Wesley Roy, Bhumireddy, Archana, Giri, Sanjeev, Gopinath, Sreevalsam, Samiulla, Dodheri S, Daginakatte, Girish, Basavaraju, Aravind, Chelur, Shekar, Eswarappa, Rajesh, Belliappa, Charamanna, Subramanya, Hosahalli S, Booher, Robert N, Ramachandra, Murali, Samajdar, Susanta

“…Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified from Aurigene’s compound…”
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Abstract 3646: Novel IRAK-4 inhibitors exhibit highly potent anti-proliferative activity in DLBCL cell lines with activating MYD88 L265P mutation by Balasubramanian, Wesley Roy, Gummadi, Venkateshwar Rao, D, Ravi Krishna Babu, Marappan, Sivapriya, Choudhary, Bhavesh, Gopinath, Sreevalsam, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Ramachandra, Murali

“…Abstract Interleukin-1 Receptor Associated Kinase-4 (IRAK-4) is a serine/threonine protein kinase belonging to tyrosine like kinase (TLK) family. IRAK-4 is one…”
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Abstract 4798: Efficacy and safety of highly selective novel IRAK4 inhibitors for treatment of ABC-DLBCL by Balasubramanian, Wesley Roy, Gummadi, Venkateshwar Rao, Nellore, Kavitha, Mukherjee, Subhendu, Marappan, Sivapriya, Basavaraju, Aravind, Ainan, Bharathi Raja, Daginakatte, Girish, Gopinath, Sreevalsam, Giri, Sanjeev, Antony, Thomas, Chelur, Shekar, Samajdar, Susanta, Pandit, Chetan, Ramachandra, Murali

“…Abstract Interleukin-1 receptor associated kinases (IRAKs) are serine/threonine protein kinases belonging to the tyrosine-like kinase (TLK) family. IRAKs…”
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Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode by Gummadi, Venkateshwar Rao, Rajagopalan, Sujatha, Looi, Chung-Yeng, Paydar, Mohammadjavad, Renukappa, Girish Aggunda, Ainan, Bharathi Raja, Krishnamurthy, Narasimha Rao, Panigrahi, Sunil Kumar, Mahasweta, Kumari, Raghuramachandran, Sangeetha, Rajappa, Manoj, Ramanathan, Anuradha, Lakshminarasimhan, Anirudha, Ramachandra, Murali, Wong, Pooi-Fong, Mustafa, Mohammad Rais, Nanduri, Srinivas, Hosahalli, Subramanya

“…A novel series of 7-Azaindole derivatives have been identified as potent ALK inhibitors. Their synthesis and preliminary SAR are described. We have identified…”
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Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3 by Samiulla, Dodheri Syed, Naidu, Andra, Rao, Gummadi Venkateshwar, Ramachandra, Murali

“…Background Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a…”
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