Rheological properties of an original pharmaceutical composition of a nanostructured silver system stabilized by arabinogalactan
Rheological properties of an original pharmaceutical composition of a nanostructured (ultradisperse) silver system stabilized by arabinogalactan were studied by dynamic rheology and compared with the official silver- containing preparation dermazin. Significant differences were observed in the rheol...
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| Published in: | Pharmaceutical chemistry journal Vol. 47; no. 2; pp. 99 - 102 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Boston
Springer US
01-05-2013
Springer |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Rheological properties of an original pharmaceutical composition of a nanostructured (ultradisperse) silver system stabilized by arabinogalactan were studied by dynamic rheology and compared with the official silver- containing preparation dermazin. Significant differences were observed in the rheological characteristics of the soft dosage forms that affected their adherence to skin, the bioavailability of the active ingredients, and the production technology. It was established that the original pharmaceutical composition of the ultradisperse silver system stabilized by arabinogalactan was a structured liquid with clearly pronounced non-Newtonian flow characteristics that exhibited viscoplastic and thixotropic properties. Its rheological parameters corresponded well to requirements for the technical rheological optimum for extrusion of hydrophilic gels. |
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| ISSN: | 0091-150X 1573-9031 |
| DOI: | 10.1007/s11094-013-0904-7 |