Endocrine cells in the human common bile duct in patients with obstructive jaundice

There was no data about endocrine cells in the extrahepatic bile duct in secondary cholangitis due to obstructive jaundice. The aim of the present study is to investigate immunohistochemically the endocrine cell types in the lower part of the human common bile duct in biopsy samples, collected durin...

Full description

Saved in:

Bibliographic Details
Published in:	Hepato-gastroenterology Vol. 59; no. 113; p. 26
Main Authors:	Gulubov, Maya V, Hadjipetkov, Philip, Sivrev, Dimiter, Ilieva, Galya
Format:	Journal Article
Language:	English
Published:	Greece 01-01-2012
Subjects:	Adult Aged Aged, 80 and over Biopsy Bulgaria Choledocholithiasis - complications Choledocholithiasis - metabolism Choledocholithiasis - pathology Choledocholithiasis - surgery Chromogranin A - analysis Common Bile Duct - chemistry Common Bile Duct - pathology Common Bile Duct - surgery Drainage Endocrine Cells - chemistry Endocrine Cells - pathology Female Gastrins - analysis Humans Immunohistochemistry Jaundice, Obstructive - etiology Jaundice, Obstructive - metabolism Jaundice, Obstructive - pathology Jaundice, Obstructive - surgery Male Microscopy, Electron Middle Aged Secretin - analysis Serotonin - analysis Somatostatin - analysis Synaptophysin Vesicular Transport Proteins - analysis Bulgaria
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	There was no data about endocrine cells in the extrahepatic bile duct in secondary cholangitis due to obstructive jaundice. The aim of the present study is to investigate immunohistochemically the endocrine cell types in the lower part of the human common bile duct in biopsy samples, collected during drainage because of complete or incomplete obstruction, caused mainly by stones. We explained the presence of various hormone-producing endocrine cells in this region with the regulation of physiological and pathological processes there. We used light and electron microscopic immunohistochemistry. More gastrin-positive, somatostatin-positive, secretin-positive, serotonin-positive, chromogranin- A-positive and synaptophysin-positive endocrine cells were found compared to control preparations. Occurrence of endocrine cells may relate to disturbed bile flow and to formation of calculi. Endocrine cell hyperplasia may be related to longstanding inflammation as in chronic cholecystitis and all secreted hormones from the described ECs can support pathologic process in the choledochus, i.e. inflammation, increased mucus secretion, fibrosis, muscle contraction, etc. We may state that various ECs (similar to those in duodenum) present in the lower part of the large bile duct and their hormones exert action on physiology (motility, secretion) and pathology (inflammation and fibrosis) in that part of the biliary tree.
ISSN:	0172-6390
DOI:	10.5754/hge10227