Search Results - "Gulley, Joshua M."

Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos by Walker, Deena M, Bell, Margaret R, Flores, Cecilia, Gulley, Joshua M, Willing, Jari, Paul, Matthew J

“…Adolescence is a time of significant neural and behavioral change with remarkable development in social, emotional, and cognitive skills. It is also a time of…”
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Age and sex differences in reward behavior in adolescent and adult rats by Hammerslag, Lindsey R., Gulley, Joshua M.

“…ABSTRACT Compared to adults, adolescents are at heightened risk for drug abuse and dependence. One of the factors contributing to this vulnerability may be…”
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Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HT2C receptor localization in the orbitofrontal cortex of Sprague-Dawley rats by Hankosky, Emily R., Westbrook, Sara R., Haake, Rachel M., Willing, Jari, Raetzman, Lori T., Juraska, Janice M., Gulley, Joshua M.

“…•Drug-induced neuroadaptations and cognitive impairment depend on age and sex.•Methamphetamine self-administration impairs reversal learning in adolescent…”
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A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior by Hall, Darien A., Stanis, Jessica J., Marquez Avila, Hector, Gulley, Joshua M.

“…Rationale Methamphetamine (METH) is typically characterized as a more potent psychostimulant than amphetamine (AMPH), but few studies have directly compared…”
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Blockade of D1 dopamine receptors in the medial prefrontal cortex attenuates amphetamine- and methamphetamine-induced locomotor activity in the rat by Hall, Darien A, Powers, John P, Gulley, Joshua M

“…Abstract The medial prefrontal cortex (mPFC) is a component of the mesolimbic dopamine (DA) system involved in psychostimulant-induced hyperactivity and…”
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Sex differences in behavior and neural development and their role in adolescent vulnerability to substance use by Hammerslag, Lindsey R., Gulley, Joshua M.

“…•Male and female adolescents differ in depression and substance use vulnerability.•There are also adolescent sex differences in risk-taking and sensation…”
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Adolescent drug addiction by Gulley, Joshua M., Izenwasser, Sari

“…•Adolescence is a time of significant changes in neurobiology and behavior.•Early-onset drug use is associated with worse outcomes compared to later-onset…”
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Disparate cocaine-induced locomotion as a predictor of choice behavior in rats trained in a delay-discounting task by Stanis, Jessica J, Burns, Randi M, Sherrill, Luke K, Gulley, Joshua M

“…Abstract Heightened impulsivity and differential sensitivity to a drug's behavioral effects are traits that, individually, have been associated with chronic…”
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The effects of moderate alcohol and THC co-use during male and female rat adolescence on AKT-GSK3ß signaling in adulthood by Shi, Linyuan, Choi, Chan Young, Carrica, Lauren K., Liang, Nu-Chu, Gulley, Joshua M.

“…Alcohol and cannabis are often taken in combination, and extensive co-use has been linked to enduring changes in cognitive and metabolic functioning. The…”
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The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines by Carrica, Lauren K, Gulley, Joshua M

“…Use of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are…”
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Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats by Westbrook, Sara R., Dwyer, Megan R., Cortes, Laura R., Gulley, Joshua M.

“…•Females and adolescent-onset rats escalate METH intake more than their counterparts.•Self-administration history did not impact novel objection recognition…”
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Effects of amphetamine exposure during adolescence on behavior and prelimbic cortex neuron activity in adulthood by Sherrill, Luke K., Gulley, Joshua M.

“…•Rats exposed to amphetamine in adolescence are hypersensitive to D1 and D2 agonists.•Adolescent amphetamine exposure enhances antagonist-induced reversal of…”
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AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development by Westbrook, Sara R., Carrica, Lauren K., Banks, Asia, Gulley, Joshua M.

“…Adolescent use of amphetamine and its closely related, methylated version methamphetamine, is alarmingly high in those who use drugs for nonmedical purposes…”
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High frequency stimulation-induced plasticity in the prelimbic cortex of rats emerges during adolescent development and is associated with an increase in dopamine receptor function by Kang, Shuo, Cox, Charles L., Gulley, Joshua M.

“…Recent studies in rats suggest that high frequency stimulation (HFS) in the ventral hippocampus induces long-term depression (LTD) in the deep layer of the…”
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Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine D 1 receptor expression in young adulthood by Kang, Shuo, Wu, Mariah M, Galvez, Roberto, Gulley, Joshua M

“…Non-medical use of amphetamine (AMPH) among adolescents is prevalent, which is problematic given the potential consequences of developmental drug exposure on…”
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Effects of the GluN2B antagonist, Ro 25-6981, on extinction consolidation following adolescent- or adult-onset methamphetamine self-administration in male and female rats by Westbrook, Sara R., Gulley, Joshua M.

“…Previous work suggests adolescent rats have deficient extinction consolidation relative to adults. Although the mechanisms underlying this age difference are…”
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Brief, repeated exposure to substrates down‐regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo by Gulley, Joshua M., Doolen, Suzanne, Zahniser, Nancy R.

“…In heterologous expression systems, dopamine transporter (DAT) cell‐surface localization is reduced after relatively prolonged exposure to d‐amphetamine (AMPH)…”
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Timing of amphetamine exposure in relation to puberty onset determines its effects on anhedonia, exploratory behavior, and dopamine D1 receptor expression in young adulthood by Kang, Shuo, Wu, Mariah M, Galvez, Roberto, Gulley, Joshua M

“…Highlights • Anxiety-related behavior was lower in adults first given amphetamine pre-puberty. • This effect was associated with a decrease in D1 receptor…”
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Effects of combined exposure to ethanol and delta-9-tetrahydrocannabinol during adolescence on synaptic plasticity in the prefrontal cortex of Long Evans rats by Shi, Linyuan, Kang, Shuo, Choi, Chan Young, Noonan, Brynn L., Carrica, Lauren K., Liang, Nu-Chu, Gulley, Joshua M.

“…Significant exposure to alcohol or cannabis during adolescence can induce lasting disruptions of neuronal signaling in brain regions that are later to mature,…”
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Repeated exposure to amphetamine during adolescence alters inhibitory tone in the medial prefrontal cortex following drug re-exposure in adulthood by Paul, Kush, Kang, Shuo, Cox, Charles L., Gulley, Joshua M.

“…•Inhibitory tone in prefrontal cortex pyramidal cells is increased by amphetamine.•This effect is abolished in rats pre-exposed to amphetamine.•With…”
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