Search Results - "Gullapalli, Srinivas"

Regulation of Opioid Receptors by Their Endogenous Opioid Peptides by Gupta, Achla, Gullapalli, Srinivas, Pan, Hui, Ramos-Ortolaza, Dinah L., Hayward, Michael D., Low, Malcom J., Pintar, John E., Devi, Lakshmi A., Gomes, Ivone

“…Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major…”
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GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models by Charrua, Ana, Cruz, Célia D, Narayanan, Shridhar, Gharat, Laxmikant, Gullapalli, Srinivas, Cruz, Francisco, Avelino, António

“…We evaluated the effects of GRC-6211, an orally active TRPV1 antagonist, on the function and noxious input of naïve and inflamed bladders. In urethane…”
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Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)‑one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists by Lingam, V. S. Prasadarao, Dahale, Dnyaneshwar H, Rathi, Vijay E, Shingote, Yogesh B, Thakur, Rajni R, Mindhe, Ajit S, Kummari, Srinivas, Khairatkar-Joshi, Neelima, Bajpai, Malini, Shah, Daisy M, Sapalya, Ratika S, Gullapalli, Srinivas, Gupta, Praveen K, Gudi, Girish S, Jadhav, Satyawan B, Pattem, Rambabu, Thomas, Abraham

“…We report the design and synthesis of novel 5,6-diarylated pyridin-2­(1H)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular…”
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Abstract 1701: EPL-1410, a novel fused heterocycle based orally active dual inhibitor of IDO1/TDO2, as a potential immune-oncology therapeutic by Gullapalli, Srinivas, Roychowdhury, Abhijit, Khaladkar, Tushar, Sawargave, Sangameshaver, Janrao, Ravindra, Kalhapure, Vijay, Urunkar, Ganesh, Kulathingal, Jayanarayan, Lekkala, Ramamohan Reddy, Bhadra, Sonali, Singh, Pankaj Kumar, Putta, Krishna Anand, Manwatkar, Sonali, Surve, Prashant, Gurjar, Mukund Keshav

“…Many tumors use tryptophan (Trp)-catabolizing enzymes such as Indoleamine/Tryptophan-2,3-dioxygenases (IDO1/TDO2) to induce an immunosuppressive environment by…”
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Modulation of Opiate-Related Signaling Molecules in Morphine-Dependent Conditioned Behavior: Conditioned Place Preference to Morphine Induces CREB Phosphorylation by MORON, José A, GULLAPALLI, Srinivas, TAYLOR, Chirisse, GUPTA, Achla, GOMES, Ivone, DEVI, Lakshmi A

“…Opiate addiction is a chronic, relapsing behavioral disorder where learned associations that develop between the abused opiate and the environment in which it…”
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Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model by Banerjee, Abhisek, Patil, Sandip, Pawar, Mahesh Y., Gullapalli, Srinivas, Gupta, Praveen K., Gandhi, Maulik N., Bhateja, Deepak K., Bajpai, Malini, Sangana, Ramachandra Rao, Gudi, Girish S., Khairatkar-Joshi, Neelima, Gharat, Laxmikant A.

“…The synthesis and structure-activity relationship studies of a series of compounds from imidazopyridazinone scaffold as PDE7 inhibitors are disclosed. Potent…”
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Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors by Banerjee, Abhisek, Narayana, Lakshminarayana, Raje, Firoj A., Pisal, Dnyandeo V., Kadam, Pradip A., Gullapalli, Srinivas, Kumar, Hemant, More, Sandeep V., Bajpai, Malini, Sangana, Ramachandra Rao, Jadhav, Satyawan, Gudi, Girish S., Khairatkar-Joshi, Neelima, Merugu, Ravi R.T., Voleti, Sreedhara R., Gharat, Laxmikant A.

“…The design, synthesis and structure activity relationship studies of a series of compounds from benzo[d]imidazo[5,1-b]thiazole scaffold as phosphodiesterase…”
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Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation by Banerjee, Abhisek, Yadav, Pravin S., Bajpai, Malini, Sangana, Ramachandra Rao, Gullapalli, Srinivas, Gudi, Girish S., Gharat, Laxmikant A.

“…The synthesis and structure–activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic…”
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Characterization of active and inactive states of CB1 receptor and the differential binding state modulation by cannabinoid agonists, antagonists and inverse agonists by Gullapalli, Srinivas, Amrutkar, Dipak, Gupta, Sangeetha, Kandadi, Machender R., Kumar, Hemant, Gandhi, Maulik, Karande, Vikas, Narayanan, Shridhar

“…Cannabinoid 1 (CB1) receptors have the ability to change conformation between active (R*) and inactive (R) receptor states. Herein, we further characterize…”
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Role of L-type Ca(2+) channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia by Gullapalli, Srinivas, Ramarao, Poduri

“…Previous studies have shown that the kappa-opioid effects are sensitive to pertussis toxin (PTX) and affected by Ca(2+) fluxes. However, the possible…”
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Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II by Das, Sanjib, Shelke, Dnyaneshwar E, Harde, Rajendra L, Avhad, Vijayshree B, Khairatkar-Joshi, Neelima, Gullapalli, Srinivas, Gupta, Praveen K, Gandhi, Maulik N, Bhateja, Deepak K, Bajpai, Malini, Joshi, Ashwini A, Marathe, Megha Y, Gudi, Girish S, Jadhav, Satyawan B, Mahat, Mahamad Yunnus A, Thomas, Abraham

“…We report the design and synthesis of novel pyrrolo[3,2-b]quinoline containing heteroarene ethers as PDE10A inhibitors with good to excellent potency,…”
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Regulation of dihydropyridine-sensitive Ca(2+) channels during naloxone-induced opioid supersensitivity in rats by Gullapalli, Srinivas, Ramarao, Poduri

“…The Ca(2+) channel blocker, nimodipine, increases the chronic naltrexone-induced supersensitivity to morphine analgesia in mice without affecting the density…”
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Regulation of dihydropyridine-sensitive Ca2+ channels during naloxone-induced opioid supersensitivity in rats by GULLAPALLI, Srinivas, RAMARAO, Poduri

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Role of L-type Ca 2+ channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia by Gullapalli, Srinivas, Ramarao, Poduri

“…Previous studies have shown that the κ-opioid effects are sensitive to pertussis toxin (PTX) and affected by Ca 2+ fluxes. However, the possible involvement of…”
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Regulation of dihydropyridine-sensitive Ca 2+ channels during naloxone-induced opioid supersensitivity in rats by Gullapalli, Srinivas, Ramarao, Poduri

“…The Ca 2+ channel blocker, nimodipine, increases the chronic naltrexone-induced supersensitivity to morphine analgesia in mice without affecting the density of…”
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Role of L-type Ca2+ channels in pertussis toxin induced antagonism of U50,488H analgesia and hypothermia by GULLAPALLI, Srinivas, RAMARAO, Poduri

“…Previous studies have shown that the Kappa -opioid effects are sensitive to pertussis toxin (PTX) and affected by Ca2+ fluxes. However, the possible…”
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Role of Ca 2+ channels on the hypothermic response produced by activation of κ-opioid receptors by Gullapalli, Srinivas, Nemmani, Kumar V.S., Ramarao, Poduri

“…The effect of nimodipine (NIM) and lercanidipine (LER) 1,4-dihydropyridine (DHP) calcium channel blockers (CCBs) on the hypothermic response of selective…”
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Role of L-type Ca2+ channels in attenuated morphine antinociception in streptozotocin-diabetic rats by GULLAPALLI, Srinivas, GURUMOORTHY, Krishnamoorthy, CHAMAN LAL KAUL, RAMARAO, Poduri

“…The role of L-type Ca2+ channels in morphine antinociception was studied in streptozotocin-induced diabetic and control rats, using [3H]PN200-110 [isopropyl…”
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Role of L-type Ca 2+channels in attenuated morphine antinociception in streptozotocin-diabetic rats by Gullapalli, Srinivas, Gurumoorthy, Krishnamoorthy, Kaul, Chaman Lal, Ramarao, Poduri

“…The role of L-type Ca 2+ channels in morphine antinociception was studied in streptozotocin-induced diabetic and control rats, using [ 3H]PN200-110 {isopropyl…”
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Potentiation of κ-opioid receptor agonist-induced analgesia and hypothermia by fluoxetine by Nemmani, Kumar V.S, Gullapalli, Srinivas, Ramarao, Poduri

“…The effect of fluoxetine, a selective 5-HT reuptake inhibitor on the analgesic and hypothermic response of trans-(±)-3,4-dichloro- N-methyl-…”
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