Search Results - "Gullans, SR"

Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes by TAKAHASHI, Tomosaburo, LORD, Bernadette, SCHULZE, P. Christian, FRYER, Ryan M, SARANG, Satinder S, GULLANS, Steven R, LEE, Richard T

“…Embryonic stem (ES) cells are capable of self-renewal and differentiation into cellular derivatives of all 3 germ layers. In appropriate culture conditions, ES…”
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Translation of microarray data into clinically relevant cancer diagnostic tests using gene expression ratios in lung cancer and mesothelioma by GORDON, Gavin J, JENSEN, Roderick V, HSIAO, Li-Li, GULLANS, Steven R, BLUMENSTOCK, Joshua E, RAMASWAMY, Sridhar, RICHARDS, William G, SUGARBAKER, David J, BUENO, Raphael

“…The pathological distinction between malignant pleural mesothelioma (MPM)and adenocarcinoma (ADCA) of the lung can be cumbersome using established methods. We…”
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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript by Rogers, Jack T, Randall, Jeffrey D, Cahill, Catherine M, Eder, Paul S, Huang, Xudong, Gunshin, Hiromi, Leiter, Lorene, McPhee, Jay, Sarang, Satinder S, Utsuki, Tada, Greig, Nigel H, Lahiri, Debomoy K, Tanzi, Rudolph E, Bush, Ashley I, Giordano, Tony, Gullans, Steve R

“…Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis by regulating ferritin translation and transferrin receptor mRNA…”
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Better therapeutics through microarrays by Gerhold, David L, Jensen, Roderick V, Gullans, Steven R

“…DNA microarrays are an integral part of the process for therapeutic discovery, optimization and clinical validation. At an early stage, investigators use…”
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DNA mapping using microfluidic stretching and single-molecule detection of fluorescent site-specific tags by Chan, Eugene Y, Goncalves, Nuno M, Haeusler, Rebecca A, Hatch, Amie J, Larson, Jonathan W, Maletta, Anthony M, Yantz, Gregory R, Carstea, Eugene D, Fuchs, Martin, Wong, Gordon G, Gullans, Steven R, Gilmanshin, Rudolf

“…We have developed a rapid molecular mapping technology--Direct Linear Analysis (DLA)--on the basis of the analysis of individual DNA molecules bound with…”
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Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter by Dangond, Fernando, Hwang, Daehee, Camelo, Sandra, Pasinelli, Piera, Frosch, Matthew P, Stephanopoulos, Gregory, Stephanopoulos, George, Brown, Robert H., Jr, Gullans, Steven R

“…1 Laboratory of Transcriptional and Immune Regulation, Center for Neurologic Diseases, Brigham and Women’s Hospital, Department of Neurology, Harvard Medical…”
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Single DNA molecule stretching in sudden mixed shear and elongational microflows by Larson, Jonathan W, Yantz, Gregory R, Zhong, Qun, Charnas, Rebecca, D'Antoni, Christina M, Gallo, Michael V, Gillis, Kimberly A, Neely, Lori A, Phillips, Kevin M, Wong, Gordon G, Gullans, Steven R, Gilmanshin, Rudolf

“…High-throughput stretching and monitoring of single DNA molecules in continuous elongational flow offers compelling advantages for biotechnology applications…”
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Differential Expression of Human Histone Deacetylase mRNAs in Response to Immune Cell Apoptosis Induction by Trichostatin A and Butyrate by Dangond, Fernando, Gullans, Steven R.

“…The reversible acetylation of histones by histone deacetylases (HDACs) and acetyltransferases (HATs) plays a fundamental role in gene transcription. We…”
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Transcriptional Activation of Placental Growth Factor by the Forkhead/Winged Helix Transcription Factor FoxD1 by Zhang, Hong, Palmer, Rachel, Gao, Xiaobo, Kreidberg, Jordan, Gerald, William, Hsiao, Lili, Jensen, Roderick V., Gullans, Steven R., Haber, Daniel A.

“…Stromal-epithelial interactions play an important role in renal organogenesis [1]. Expression of the forkhead/winged helix transcription factor FoxD1 (BF-2) is…”
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Single-Molecule Detection of Transcription Factor Binding to DNA in Real Time:  Specificity, Equilibrium, and Kinetic Parameters by Nalefski, Eric A, Nebelitsky, Eugene, Lloyd, Janice A, Gullans, Steven R

“…Specificity and temporal control of transcriptional machinery are encoded within sequence-specific transcription factors, of which there are thousands in…”
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Global Analysis of Gene Expression in Renal Ischemia–Reperfusion in the Mouse by Yoshida, Takumi, Tang, Shiow-Shih, Hsiao, Li-Li, Jensen, Roderick V., Ingelfinger, Julie R., Gullans, Steven R.

“…Ischemia-induced acute renal failure (ARF) is a relatively common disorder with major morbidity and mortality. To study global gene expression during ARF,…”
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Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol by Payton, Sandra, Cahill, Catherine M, Randall, Jeffrey D, Gullans, Steven R, Rogers, Jack T

“…We screened for drugs that specifically interact with the 5'-untranslated region of the mRNA encoding the Alzheimer's amyloid precursor protein (APP). Our goal…”
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12-Lipoxygenase in Opioid-Induced Delayed Cardioprotection: Gene Array, Mass Spectrometric, and Pharmacological Analyses by Patel, Hemal H, Fryer, Ryan M, Gross, Eric R, Bundey, Richard A, Hsu, Anna K, Isbell, Marilyn, Eusebi, Leonard O.V, Jensen, Roderick V, Gullans, Steven R, Insel, Paul A, Nithipatikom, Kasem, Gross, Garrett J

“…ABSTRACT—12-Lipoxygenase (12-LO) has been shown to be a factor in acute ischemic preconditioning (IPC) in the isolated rat heart; however, no studies have been…”
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Osmotic stress protein 94 (Osp94). A new member of the Hsp110/SSE gene subfamily by Kojima, R, Randall, J, Brenner, B M, Gullans, S R

“…Preservation of cell viability and function in the hyperosmolar environment of the renal medulla is a complex process that requires selective gene expression…”
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HugeIndex: a database with visualization tools for high-density oligonucleotide array data from normal human tissues by Haverty, Peter M, Weng, Zhiping, Best, Nathan L, Auerbach, Kenneth R, Hsiao, Li-Li, Jensen, Roderick V, Gullans, Steven R

“…High-density oligonucleotide arrays are a powerful tool for uncovering changes in global gene expression in various disease states. To this end, it is…”
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Genomic Organization of the Gene Coding for TIRC7, a Novel Membrane Protein Essential for T Cell Activation by Heinemann, Thomas, Bulwin, Grit-Carsta, Randall, Jeffrey, Schnieders, Barbara, Sandhoff, Konrad, Volk, Hans-Dieter, Milford, Edgar, Gullans, Steven R., Utku, Nalân

“…A novel human membrane protein, TIRC7, was recently identified and demonstrated to be essential in T cell activation. Here we report on the genomic…”
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Of microarrays and meandering data points by Gullans, Steven R

“…Microarray analysis greatly assists in defining functions of genes and elucidating important biological pathways. To enhance this power, a database or…”
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Urea Inducibility of egr-1 in Murine Inner Medullary Collecting Duct Cells Is Mediated by the Serum Response Element and Adjacent Ets Motifs by Cohen, D M, Gullans, S R, Chin, W W

“…The renal medullary solute urea increases transcription and protein expression of the zinc finger-containing transcription factor Egr-1 in a renal epithelial…”
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Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein by Utku, N, Heinemann, T, Tullius, S G, Bulwin, G C, Beinke, S, Blumberg, R S, Beato, F, Randall, J, Kojima, R, Busconi, L, Robertson, E S, Schülein, R, Volk, H D, Milford, E L, Gullans, S R

“…A novel 75 kDa membrane protein, TIRC7, is described that exhibits a central role in T cell activation in vitro and in vivo. Modulation of TIRC7-mediated…”
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Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase by Cohen, D M, Gullans, S R, Chin, W W

“…Urea, in concentrations unique to the renal medulla, increases transcription and protein expression of several immediate-early genes (IEGs) including the zinc…”
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