Search Results - "Gulla, Stefano"

Co-inhibitory T cell receptor KLRG1: human cancer expression and efficacy of neutralization in murine cancer models by Greenberg, Steven A, Kong, Sek Won, Thompson, Evan, Gulla, Stefano V

“…KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector and effector memory CD8+ T and NK…”
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521 mRNA encoded antibodies improve biodistribution and efficacy of checkpoint inhibitors for liver cancer by Wei, Shuo, Mobley, Melissa, Tao, Ran, Li, Yupeng, Townsend, Sara, Vahey, Alexa, Gregory, Sonia, Zhou, Yue, Zhang, Jason, Gulla, Stefano

“…BackgroundLipid nanoparticle (LNP) encapsulated mRNA is emerging as a powerful new modality to deliver protein therapeutic to specific tissues. Of particular…”
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Synthesis of a spin-labeled anti-estrogen as a dynamic motion probe for the estrogen receptor ligand binding domain by Adam Hendricks, J., Gullà, Stefano V., Budil, David E., Hanson, Robert N.

“…The preparation and characterization of a novel nitroxide spin probe based on a steroidal anti-estrogen is described. The probe 5 demonstrated very high…”
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Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl‑1 in Cells by Foight, Glenna Wink, Ryan, Jeremy A, Gullá, Stefano V, Letai, Anthony, Keating, Amy E

“…Mcl-1 is overexpressed in many cancers and can confer resistance to cell-death signaling in refractory disease. Molecules that specifically inhibit Mcl-1 hold…”
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Dynamic Conformational Responses of a Human Cannabinoid Receptor-1 Helix Domain to Its Membrane Environment by Tiburu, Elvis K, Gulla, Stefano V, Tiburu, Mark, Janero, David R, Budil, David E, Makriyannis, Alexandros

“…The influence of membrane environment on human cannabinoid 1 (hCB1) receptor transmembrane helix (TMH) conformational dynamics was investigated by solid-state…”
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Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes by Fire, Emiko, Gullá, Stefano V., Grant, Robert A., Keating, Amy E.

“…Mcl‐1 is an antiapoptotic Bcl‐2‐family protein that protects cells against death. Structures of Mcl‐1, and of other anti‐apoptotic Bcl‐2 proteins, reveal a…”
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In Silico and in Vitro Elucidation of BH3 Binding Specificity toward Bcl-2 by London, Nir, Gullá, Stefano, Keating, Amy E, Schueler-Furman, Ora

“…Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their…”
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Abstract 3227: Differential expression of T cell co-inhibitory receptors: KLRG1 alignment with cytotoxicity and adaptive resistance mechanisms by Greenberg, Steven A., Thompson, Evan, Gulla, Stefano V.

“…Introduction: KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector and effector memory…”
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Abstract LB-301: Inhibition of the co-inhibitory receptor KLRG1 reduces murine 4T1 breast cancer metastasis and MC38 colon cancer primary tumor growth and mortality by Greenberg, Steven A., Gulla, Stefano V., Thompson, Evan

“…Introduction Targeting of lymphocyte co-inhibitory receptors, such as CTLA-4, PD-1, Lag-3, and Tim-3, has gained intense interest for treatment of cancer…”
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Molecular-Scale Force Measurement in a Coiled-Coil Peptide Dimer by Electron Spin Resonance by Gullà, Stefano V, Sharma, Gaurav, Borbat, Peter, Freed, Jack H, Ghimire, Harishchandra, Benedikt, Monica R, Holt, Natasha L, Lorigan, Gary A, Rege, Kaushal, Mavroidis, Constantinos, Budil, David E

“…A new method for measuring forces between small protein domains based on double electron−electron resonance (DEER) spectroscopy is demonstrated using a model…”
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TLR Stimulation Produces IFN-β as the Primary Driver of IFN Signaling in Nonlymphoid Primary Human Cells by Nistler, Ryan, Sharma, Ankur, Meeth, Katrina, Huard, Christine, Loreth, Christine, Kalbasi, Alireza, Tyminski, Edyta, Bellmore, Ryan, Coyle, Anthony J, Gullà, Stefano V, Berasi, Stephen P, Greenberg, Steven A, Buhlmann, Janet E

“…Several human autoimmune diseases are characterized by increased expression of type 1 IFN-stimulated genes in both the peripheral blood and tissue. The…”
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Dynamic and Strucutral Effects of Ligand and Coregulator Binding on Estrogen Receptor Ligand Binding Domain Measured by Electron Paramagnetic Resonance by Gulla, Stefano V.

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Postsynthetic modification of a coordination compound with a paddlewheel motif via click reaction: DOSY and ESR studies by Han, Shuangbing, Ma, Zhenbo, Hopson, Russell, Wei, Yanhu, Budil, David, Gulla, Stefano, Moulton, Brian

“…Postsynthetic strategy based on organic coupling reactions has been explored for the synthesis of novel coordination complexes with larger dimensions. A…”
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Ligand Induced Solution Structure and Dynamics of the Helix‐12 region of Estrogen Receptor Alpha by Gulla, Stefano Vincenzo, Budil, David E

“…The objective of the study is to elucidate the solution structure of the functionally important helix‐12 region in the ligand binding domain of human estrogen…”
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Spin label studies of interactions between the estrogen receptor and coactivator peptides by Rupert, Samantha, Barhite, Kelly, Gulla, Stefano, Budil, David Edward

“…Abstract only The estrogen receptor (ER) is a member of the family of nuclear receptors that has become an important therapeutic target for the treatment of…”
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Structural Response of the Estrogen Receptor Ligand Binding Domain to Selective Ligand Binding by Spin Label Distance Measurements by Ngu, Lisa, Gulla, Stefano, Chamoun, Jean, Fajer, Piotr G., Budil, David

“…Abstract only…”
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Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL by Dutta, Sanjib, Gullá, Stefano, Chen, T Scott, Fire, Emiko, Grant, Robert A, Keating, Amy E

“…Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3…”
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EPR study of ligand -receptor interactions: Measuring ligand induced changes in dynamics and structure of the estrogen receptor ligand binding domain by Gulla, Stefano V

“…Ligand-receptor interactions are powerful determinants of biochemical pathways. In this work, the role of ligand binding and coregulator interaction is…”
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In-silico and in-vitro elucidation of BH3 binding specificity towards Bcl-2 by London, Nir, Gullá, Stefano, Keating, Amy E., Schueler-Furman, Ora

“…Interactions between Bcl-2 like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their…”
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EPR study of ligand-receptor interactions: Measuring ligand induced changes in dynamics and structure of the estrogen receptor ligand binding domain by Gulla, Stefano V

“…Ligand-receptor interactions are powerful determinants of biochemical pathways. In this work, the role of ligand binding and coregulator interaction is…”
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