Search Results - "Gulko, Percio S."

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes by Ai, Rizi, Laragione, Teresina, Hammaker, Deepa, Boyle, David L., Wildberg, Andre, Maeshima, Keisuke, Palescandolo, Emanuele, Krishna, Vinod, Pocalyko, David, Whitaker, John W., Bai, Yuchen, Nagpal, Sunil, Bachman, Kurtis E., Ainsworth, Richard I., Wang, Mengchi, Ding, Bo, Gulko, Percio S., Wang, Wei, Firestein, Gary S.

“…Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic…”
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KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes by Laragione, Teresina, Harris, Carolyn, Gulko, Percio S

“…Huntingtin-interacting protein-1 (HIP1) is a new arthritis severity gene implicated in the regulation of the invasive properties of rheumatoid arthritis (RA)…”
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Short-term low-magnesium diet reduces autoimmune arthritis severity and synovial tissue gene expression by Brenner, Max, Laragione, Teresina, Gulko, Pércio S

“…Magnesium has been suggested to have anti-inflammatory properties in short-term, mostly in vitro studies. To examine the effect of dietary magnesium…”
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KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis by Tanner, Mark R, Pennington, Michael W, Chauhan, Satendra S, Laragione, Teresina, Gulko, Pércio S, Beeton, Christine

“…Fibroblast-like synoviocytes (FLS) and CCR7 effector memory T (T ) cells are two of the major cell types implicated in the progression of rheumatoid arthritis…”
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Cell-specific gene networks and drivers in rheumatoid arthritis synovial tissues by Pelissier, Aurelien, Laragione, Teresina, Gulko, Percio S, Rodríguez Martínez, María

“…Rheumatoid arthritis (RA) is a common autoimmune and inflammatory disease characterized by inflammation and hyperplasia of the synovial tissues. RA…”
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Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice by Chen, Lili, Deshpande, Madhura, Grisotto, Marcos, Smaldini, Paola, Garcia, Roberto, He, Zhengxiang, Gulko, Percio S., Lira, Sergio A., Furtado, Glaucia C.

“…Psoriasis (PS) is a chronic skin inflammation. Up to 30% of the patients with PS develop psoriatic arthritis (PsA), a condition characterized by inflammatory…”
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The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion by Laragione, Teresina, Cheng, Kai F, Tanner, Mark R, He, Mingzhu, Beeton, Christine, Al-Abed, Yousef, Gulko, Pércio S

“…Abstract Little is known about the regulation of arthritis severity and joint damage in rheumatoid arthritis (RA). Fibroblast-like synoviocytes (FLS) have a…”
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Correction: Oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus by Verlato, Alberto, Laragione, Teresina, Bin, Sofia, Kim, Randie H, Salem, Fadi, Gulko, Percio S, Cravedi, Paolo

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Computational deconvolution of synovial tissue cellular composition: presence of adipocytes in synovial tissue decreased during arthritis pathogenesis and progression by Wang, Wenhui, Wang, Li, Gulko, Percio S, Zhu, Jun

“…Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common forms of arthritis. The synovial tissue is the major site of inflammation of OA and RA…”
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Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes by Pethő, Zoltán, Tanner, Mark R, Tajhya, Rajeev B, Huq, Redwan, Laragione, Teresina, Panyi, Gyorgy, Gulko, Pércio S, Beeton, Christine

“…Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express…”
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DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis by Laragione, Teresina, Harris, Carolyn, Rice, Natasha, Gulko, Percio S.

“…Receptor tyrosine kinases (RTKs) have an important role in arthritis severity and in models of rheumatoid arthritis (RA), but their regulation is not fully…”
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Disease modifying anti-rheumatic activity of the alkaloid montanine on experimental arthritis and fibroblast-like synoviocytes by Farinon, Mirian, Clarimundo, Vanessa S., Pedrazza, Graziele P.R., Gulko, Pércio S., Zuanazzi, José A.S., Xavier, Ricardo M., de Oliveira, Patricia G.

“…Montanine is an alkaloid isolated from Rhodophiala bifida bulb with potential anti-arthritic activity. In this context, we evaluated whether montanine has a…”
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Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes by Torres, Alyssa, Kang, Sarah, Mahony, Christopher B, Cedeño, Martha, Oliveira, Patricia G, Fernandez-Bustamante, Marta, Kemble, Samuel, Laragione, Teresina, Gulko, Percio S, Croft, Adam P, Sanchez-Lopez, Elsa, Miyamoto, Shigeki, Guma, Monica

“…Glucose metabolism, specifically, hexokinase 2 (HK2), has a critical role in rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) phenotype. HK2…”
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Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat by Tuncel, Jonatan, Haag, Sabrina, Hoffmann, Markus H, Yau, Anthony C Y, Hultqvist, Malin, Olofsson, Peter, Bäcklund, Johan, Nandakumar, Kutty Selva, Weidner, Daniela, Fischer, Anita, Leichsenring, Anna, Lange, Franziska, Haase, Claus, Lu, Shemin, Gulko, Percio S, Steiner, Günter, Holmdahl, Rikard

“…To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several…”
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KCa1.1 Inhibition Attenuates Fibroblast‐like Synoviocyte Invasiveness and Ameliorates Disease in Rat Models of Rheumatoid Arthritis by Tanner, Mark R., Hu, Xueyou, Huq, Redwan, Tajhya, Rajeev B., Sun, Liang, Khan, Fatima S., Laragione, Teresina, Horrigan, Frank T., Gulko, Pércio S., Beeton, Christine

“…Objective Fibroblast‐like synoviocytes (FLS) participate in joint inflammation and damage in rheumatoid arthritis (RA) and its animal models. The purpose of…”
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Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity by Brenner, Max, Laragione, Teresina, Gulko, Pércio S

“…Little is known about the genes regulating disease severity and joint damage in rheumatoid arthritis (RA). In the present study we analyzed the gene expression…”
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KCa1.1 Potassium Channels Regulate Key Proinflammatory and Invasive Properties of Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Hu, Xueyou, Laragione, Teresina, Sun, Liang, Koshy, Shyny, Jones, Karlie R., Ismailov, Iskander I., Yotnda, Patricia, Horrigan, Frank T., Gulko, Pércio S., Beeton, Christine

“…Fibroblast-like synoviocytes (FLS) play important roles in the pathogenesis of rheumatoid arthritis (RA). Potassium channels have regulatory roles in many cell…”
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Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1β, and NF-κB activators' expression in pristane-induced arthritis by Brenner, Max, Laragione, Teresina, Gulko, Pércio S

“…Cia4 is a locus on rat chromosome 7 that regulates disease severity and joint damage in models of rheumatoid arthritis, including pristane-induced arthritis…”
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Autoimmune and Chronic Inflammatory Disease Patients with COVID‐19 by Ungaro, Ryan C., Agrawal, Manasi, Park, Sarah, Hirten, Robert, Colombel, Jean‐Frederic, Twyman, Kathryn, Gulko, Percio S., Klang, Eyal

“…Objective There are limited data on the impact of coronavirus disease 2019 (COVID‐19) on hospitalized patients with autoimmune and chronic inflammatory disease…”
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Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide by Schaal, Justin B, Tran, Dat Q, Subramanian, Akshay, Patel, Reshma, Laragione, Teresina, Roberts, Kevin D, Trinh, Katie, Tongaonkar, Prasad, Tran, Patti A, Minond, Dmitriy, Fields, Gregg B, Beringer, Paul, Ouellette, André J, Gulko, Percio S, Selsted, Michael E

“…θ-defensins constitute a family of macrocyclic peptides expressed exclusively in Old World monkeys. The peptides are pleiotropic effectors of innate immunity,…”
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