Regulation of immune cell function and differentiation by the NKG2D receptor

NKG2D is one of the most intensively studied immune receptors of the past decade. Its unique binding and signaling properties, expression pattern, and functions have been attracting much interest within the field due to its potent antiviral and anti-tumor properties. As an activating receptor, NKG2D...

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Bibliographic Details
Published in:	Cellular and molecular life sciences : CMLS Vol. 68; no. 21; pp. 3519 - 3529
Main Authors:	Zafirova, Biljana, Wensveen, Felix M., Gulin, Maja, Polić, Bojan
Format:	Journal Article
Language:	English
Published:	Basel SP Birkhäuser Verlag Basel 01-11-2011 Springer Nature B.V
Subjects:	Animals Antiviral activity Autoimmune diseases Autoimmunity Binding sites Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Differentiation Differentiation DNA damage Hemopoiesis Humans Immune system Infection Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Life Sciences Ligands Major histocompatibility complex Mice Multi-Author Review Natural killer cells Neoplasms - immunology Neoplasms - metabolism NK Cell Lectin-Like Receptor Subfamily K - antagonists & inhibitors NK Cell Lectin-Like Receptor Subfamily K - metabolism NKG2 antigen Receptor mechanisms Signal transduction Tumors Virus Diseases - immunology Virus Diseases - metabolism Autoimmunity Viruses NKG2D NK cell development NKG2D ligands Tumors
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Summary:	NKG2D is one of the most intensively studied immune receptors of the past decade. Its unique binding and signaling properties, expression pattern, and functions have been attracting much interest within the field due to its potent antiviral and anti-tumor properties. As an activating receptor, NKG2D is expressed on cells of the innate and adaptive immune system. It recognizes stress-induced MHC class I-like ligands and acts as a molecular sensor for cells jeopardized by viral infections or DNA damage. Although the activating functions of NKG2D have been well documented, recent analysis of NKG2D-deficient mice suggests that this receptor may have a regulatory role during NK cell development. In this review, we will revisit known aspects of NKG2D functions and present new insights in the proposed influence of this molecule on hematopoietic differentiation.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s00018-011-0797-0