Jellyfish‐Based Smart Wound Dressing Devices Containing In Situ Synthesized Antibacterial Nanoparticles

Jellyfish‐Based Smart Wound Dressing Devices Containing In Situ Synthesized Antibacterial Nanoparticles

Although the negative consequences of the global phenomenon of jellyfish (JF) swarms are well recognized, the use of their biomass for practical applications is mostly limited to a niche in the Asian food industry. This fact is quite surprising since JF's biomass comprises useful biomaterials s...

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Bibliographic Details
Published in:Advanced functional materials Vol. 29; no. 38
Main Authors: Nudelman, Roman, Alhmoud, Hashim, Delalat, Bahman, Fleicher, Sharon, Fine, Eran, Guliakhmedova, Tammila, Elnathan, Roey, Nyska, Abraham, Voelcker, Nicolas H., Gozin, Michael, Richter, Shachar
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc 01-09-2019
Subjects:
antibacterial nanoparticles
Biocompatibility
Biodegradability
Biomass
biomaterials
Biomedical materials
Chemical properties
electrospinning
Food processing industry
Glycoproteins
jellyfish
Materials science
Mats
Nanofibers
Nanoparticles
Organic chemistry
Process parameters
Scaffolds
Silver
smart wound dressing
Tissue engineering
Wound healing
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Summary:Although the negative consequences of the global phenomenon of jellyfish (JF) swarms are well recognized, the use of their biomass for practical applications is mostly limited to a niche in the Asian food industry. This fact is quite surprising since JF's biomass comprises useful biomaterials such as Q‐mucin glycoprotein and collagen. In this work, the JF biomass, collected from two different species, is used to prepare electrospun scaffolds composed of nanometric “core–shell”‐type fibers, in which adjustment of the electrospinning process parameters can easily control their mechanical, morphological, and chemical properties. This nonwoven scaffold shows excellent biocompatibility and biodegradability, indicating suitability for biomedical research contexts. Performed cell proliferation assays show that the scaffold could support the growth of cardiac cells, fitting the requirement of tissue engineering. Additional incorporation of in situ‐generated silver nanoparticles in these nanofibers produced mats with potent antibacterial properties. Preclinical trials with the resulted mats on porcine wound healing models exhibit fast and complete healing of wounds. Jellyfish biomass is used as the raw material for the fabrication of biocompatible nonwoven mats using an electrospinning technique. In situ synthesis of silver nanoparticles in the mat allows it to be utilized as a smart wound dressing device, which is successfully tested on a porcine model.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201902783