Search Results - "Guler, H. P."

Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial by Pattzi, H. M. R., Pitale, S., Alpizar, M., Bennett, C., O'Farrell, A. M., Li, J., Cherrington, J. M., Guler, H.-P.

“…Aim: To determine efficacy and tolerability of dutogliptin, a dipeptidyl peptidase 4 (DPP4) inhibitor, in patients with type 2 diabetes mellitus. Methods: This…”
Get full text

dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus by Garcia-Soria, G, Gonzalez-Galvez, G, Argoud, G.M, Gerstman, M, Littlejohn, T.W. III, Schwartz, S.L, O'Farrell, A.-M, Li, X, Cherrington, J.M, Bennett, C, Guler, H.-P

“…To determine the efficacy and tolerability of PHX1149, a novel dipeptidyl peptidase-4 (DPP4) inhibitor, in patients with type 2 diabetes. This is a…”
Get full text

Effects of Recombinant Insulin-Like Growth Factor I on Insulin Secretion and Renal Function in Normal Human Subjects by Guler, Hans-Peter, Schmid, Christoph, Zapf, Jurgen, Froesch, E. Rudolf

“…Insulin-like growth factor I (IGF-I) is an important mediator of growth hormone (GH) action and it appeared tempting to evaluate possible clinical…”
Get full text

Recombinant Human Insulin-Like Growth Factor I Stimulates Growth and Has Distinct Effects on Organ Size in Hypophysectomized Rats by Guler, Hans-Peter, Zapf, Jürgen, Scheiwiller, Erika, Froesch, E. Rudolf

“…Recombinant human insulin-like growth factor I (rhIGF-I) was infused subcutaneously into hypophysectomized rats for as long as 18 days. Three hundred…”
Get full text

Recombinant Human Insulin-Like Growth Factor I Induces Its Own Specific Carrier Protein in Hypophysectomized and Diabetic Rats by Zapf, J., Hauri, C., Waldvogel, M., Futo, E., Hasler, H., Binz, K., Guler, H. P., Schmid, C., Froesch, E. R.

“…The physiology of the specific serum binding proteins which constitute the main storage pool for insulin-like growth factors (IGFs) in mammals is still…”
Get full text

Regulation of binding proteins for insulin-like growth factors (IGF) in humans : increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia by ZAPF, J, SCHMID, C, GULER, H. P, WALDVOGEL, M, HAURI, C, FUTO, E, HOSSENLOPP, P, BINOUX, M, FROESCH, E. R

“…Insulin-like growth factors (IGFs) in blood form two complexes with specific binding proteins (BPs): a large, growth hormone (GH)-dependent complex with…”
Get full text

Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults by Guler, H P, Zapf, J, Froesch, E R

“…Insulin-like growth factor I (IGF I) is structurally similar to insulin and shares many of its biologic properties. We compared the short-term metabolic…”
Get more information

Effects of insulin-like growth factor I on renal function in normal men by Hirschberg, Raimund, Brunori, Giuliano, Kopple, Joel D., Guler, Hans-Peter

“…Effects of insulin-like growth factor I on renal function in normal men. Acute and chronic studies in rats have shown that administration of human recombinant…”
Get full text

Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients by Jabri, N., Schalch, D. S., Schwartz, S. L., Fischer, J. S., Kipnes, M. S., Radnik, B. J., Turman, N. J., Marcsisin, V. S., Guler, H. P.

“…Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients. N Jabri , D S Schalch , S L Schwartz ,…”
Get full text

Insulin-like growth factor I regulates type I procollagen messenger ribonucleic acid steady state levels in bone of rats by Schmid, C, Guler, H P, Rowe, D, Froesch, E R

“…RNA extracted from parietal bones of rats was analyzed for the abundance of type I procollagen mRNA by a dot hybridization assay using specific cDNA probes…”
Get more information

Recombinant Variant of Ciliary Neurotrophic Factor for Weight Loss in Obese Adults: A Randomized, Dose-Ranging Study by Ettinger, Mark P, Littlejohn, Thomas W, Schwartz, Sherwyn L, Weiss, Stuart R, McIlwain, Harris H, Heymsfield, Steven B, Bray, George A, Roberts, William G, Heyman, Eugene R, Stambler, Nancy, Heshka, Stanley, Vicary, Catherine, Guler, Hans-Peter

“…CONTEXT: Obese individuals tend to resist the weight-regulating effects of exogenously administered leptin. A genetically engineered recombinant human variant…”
Get full text

Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure by Hirschberg, Raimund, Kopple, Joel, Lipsett, Pamela, Benjamin, Ernest, Minei, Joseph, Albertson, Timothy, Munger, Mark, Metzler, Michael, Zaloga, Gary, Murray, Michael, Lowry, Stephen, Conger, John, Mckeown, Wade, O'Shea, Michael, Baughman, Robert, Wood, Kenneth, Haupt, Marilyn, Kaiser, Roger, Simms, Hank, Warnock, David, Summer, Warren, Hintz, Raymond, Myers, Brian, Haenftling, Kathrine, Capra, William, Pike, Marilyn, Guler, Hans-Peter

“…Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Patients with acute renal failure (ARF) have…”
Get full text

Short-term effects of recombinant human insulin-like growth factor I on metabolic control of patients with type II diabetes mellitus by Schalch, D S, Turman, N J, Marcsisin, V S, Heffernan, M, Guler, H P

“…Recombinant human insulin-like growth factor I (rhIGF-I) lowers blood glucose, serum insulin, C-peptide, and lipid levels in healthy and diabetic animals and…”
Get more information

Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I by Scheiwiller, Erika, Guler, Hans-Peter, Merryweather, Jim, Scandella, Carl, Maerki, Walter, Zapf, Jürgen, Froesch, E. Rudolf

“…Insulin-like growth factor I (IGF-I) and insulin stem from a common precursor, are structural homologues, act through similar receptors and elicit insulin-like…”
Get full text

Small stature and insulin-like growth factors: prolonged treatment of mini-poodles with recombinant human insulin-like growth factor I by Guler, H P, Binz, K, Eigenmann, E, Jäggi, S, Zimmermann, D, Zapf, J, Froesch, E R

“…The short stature of mini-poodles is associated with low serum levels of IGF-I. Standard poodles are taller and have considerably higher serum levels of IGF-I…”
Get more information

Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates by Guler, H P, Zapf, J, Schmid, C, Froesch, E R

“…IGF-I and -II share specific serum carrier proteins which elute on neutral Sephadex G-200 gel permeation chromatography at apparent molecular masses of 50 and…”
Get more information

Insulin-like growth factors in the Göttinger miniature-pig by Zenobi, P D, Guler, H P, Zapf, J, Froesch, E R

“…IGF I was determined by a radioimmunoassay and IGF II by a radioreceptorassay in 20 Göttinger miniature (mini)-pigs and 13 domestic pigs of different weight…”
Get more information

Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients by JABRI, N, SCHALCH, D. S, SCHWARTZ, S. L, FISCHER, J. S, KIPNES, M. S, RADNIK, B. J, TURMAN, N. J, MARCSISIN, V. S, GULER, H.-P

“…Data from studies in diabetic rodents and evidence from clinical situations of severe resistance to insulin suggest that insulin-like growth factor I (IGF-I)…”
Get full text

Clinical uses of insulin-like growth factor I by Bondy, C A, Underwood, L E, Clemmons, D R, Guler, H P, Bach, M A, Skarulis, M

“…Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions. The therapeutic potential of recombinant human…”
Get full text

Hypoglycemic and insulin response to a continuous intravenous infusion of CGP-35126 recombinant human insulin-like growth factor-I (rhIGF-I) in healthy males by Morgan, J M, Saris, S D, Capuzzi, D M, Good, W R, John, V A, Guler, H P, Seaman, J, Piraino, A J

“…Recombinant human insulin-like growth factor-I (rhIGF-I) produced by expression in a yeast vector was evaluated in seven normal men to determine effects on…”
Get more information