Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss

Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss

To uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss. A total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years o...

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Bibliographic Details
Published in:Saudi medical journal Vol. 45; no. 8; pp. 808 - 813
Main Authors: Callioglu, Nihal, Gul, Derya K, Arslan, Ilke O, Geyikoglu, Ipek, Demircivi, Ergul
Format: Journal Article
Language:English
Published: Saudi Arabia Saudi Medical Journal 01-08-2024
Subjects:
Abortion, Spontaneous - blood
Abortion, Spontaneous - immunology
Adolescent
Adult
Biomarkers - blood
Blood cell count
Diagnosis
Female
Humans
Immune system
Inflammation
Inflammation - blood
Inflammation - immunology
Lymphocytes - immunology
Miscarriage
Monocytes - immunology
Neutrophils - immunology
Original
Platelet Count
Predictive Value of Tests
Pregnancy
Retrospective Studies
Risk factors
Testing
Young Adult
Turkey
early pregnancy loss
inflammatory biomarkers
systemic immune-inflammatory index
systemic inflammatory response index
mean platelet volume
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Summary:To uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss. A total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years old who experienced EPL. The control group comprised healthy pregnant women who gave birth at ≥37 weeks. The EPL group had significantly lower plateletcrit ( =0.04), platelet distribution width (PDW, <0.0001), and RDW ( <0.0001) and higher monocyte ( <0.0001) and SIRI ( <0.0001) values than the control group. The hemoglobin, white blood cells, platelet count, neutrophil count, lymphocyte count, mean platelet volume, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII values were not significantly different between the EPL and control groups ( >0.05). The cut-off value for the SIRI that offers the best sensitivity/specificity balance was 1.48 (sensitivity of 63%; specificity of 63%) in the receiver operating characteristics curve. Among the inflammatory parameters for predicting EPL, PDW had highest specificity (84%), and RDW had the highest sensitivity (80%). This study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker than NLR, PLR, MLR, and SII in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.
ISSN:0379-5284
1658-3175
DOI:10.15537/smj.2024.45.8.20240404