Search Results - "Gukasyan, Jaklin"

Mass Cytometry Reveals Classical Monocytes, NK Cells, and ICOS+ CD4+ T Cells Associated with Pembrolizumab Efficacy in Patients with Lung Cancer by Rochigneux, Philippe, Lisberg, Aaron, Garcia, Alejandro, Granjeaud, Samuel, Madroszyk, Anne, Fattori, Stéphane, Gonçalves, Anthony, Devillier, Raynier, Maby, Pauline, Salem, Nassim, Gorvel, Laurent, Chanez, Brice, Gukasyan, Jaklin, Carroll, James, Goldman, Jonathan, Chretien, Anne Sophie, Olive, Daniel, Garon, Edward B

“…Immune checkpoint inhibitors (ICI) have revolutionized the treatment of non-small cell lung cancer (NSCLC), but predictive biomarkers of their efficacy are…”
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Mass cytometry reveals classical monocytes, NK cells and ICOS+ CD4+ T cells associated with pembrolizumab efficacy in lung cancer patients by Rochigneux, Philippe, Lisberg, Aaron, Garcia, Alejandro, Granjeaud, Samuel, Madroszyk, Anne, Fattori, Stephane, Gonçalves, Anthony, Devillier, Raynier, Maby, Pauline, Salem, Nassim, Gorvel, Laurent, Chanez, Brice, Gukasyan, Jaklin, Carroll, James, Goldman, Jonathan, Chretien, Anne Sophie, Olive, Daniel, Garon, Edward B.

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Abstract 6614: Association between immune gene signatures and neoepitopes with electrostatic charge opposite to their HLA-B binding pocket in melanoma (MEL) and lung adenocarcinoma (LUAD) by Fares, Charlene M., Cummings, Amy L., Theisen, Matthew K., Hornstein, Nicholas, Gukasyan, Jaklin, Akingbemi, Wisdom, Li, Debory, Brodrick, Paige, Lisberg, Aaron, Garon, Edward B.

“…Abstract Purpose: Immune checkpoint blockade (ICB) has revolutionized treatment of melanoma and lung cancer. Recent evidence suggests that human leukocyte…”
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Electrostatic human leukocyte antigen-neoantigen interactions and durable benefit in non-small cell lung cancer patients treated with immunotherapy by Cummings, Amy Lauren, Gukasyan, Jaklin, Lu, Henry, Bachrach, Benji, Madrigal, John, Carroll, James M., Akingbemi, Wisdom O, Noor, Zorawar Singh, Lisberg, Aaron Elliott, Garon, Edward B.

“…Abstract only 2635 Background: Human leukocyte antigen (HLA) binding relies on energy from the interaction of B-pocket residues with anchor amino acids (AA)…”
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Prevalence of human leukocyte antigen-B27 supertype in the context of positively charged neoepitopes and association with PD-L1 as an immune escape mechanism by Fares, Charlene Marie, Cummings, Amy Lauren, Theisen, Matthew Karl, Gukasyan, Jaklin, Lind-Lebuffe, Jackson P, Akingbemi, Wisdom O, Li, Debory Y, Brodrick, Paige M, Yessuf, Nawal M, Barksdale, Chantal Ava, Wong, Deborah J.L., Lisberg, Aaron Elliott, Garon, Edward B.

“…Abstract only 3083 Background: Recent evidence suggests efficacy of immune checkpoint blockade may be influenced by human leukocyte antigen (HLA)-B. HLA-B27…”
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Immune checkpoint inhibitor induced thyroid dysfunction is a frequent event post-treatment in NSCLC by Zhou, Nanruoyi, Velez, Maria A, Bachrach, Benjamin, Gukasyan, Jaklin, Fares, Charlene M., Cummings, Amy L., Lind-Lebuffe, Jackson P., Akingbemi, Wisdom O., Li, Debory Y., Brodrick, Paige M., Yessuf, Nawal M., Rettinger, Sarah, Grogan, Tristan, Rochigneux, Philippe, Goldman, Jonathan W., Garon, Edward B., Lisberg, Aaron

“…Abbreviations: ICI; Immune checkpoint inhibitors. γClinically Acted Upon Thyroid Dysfunction is defined as thyroid diagnosis documentation and/or thyroid…”
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Human leukocyte antigen (HLA) B44 supertype and immunotherapy outcomes in non-small cell lung cancer (NSCLC) by Lu, Henry, Cummings, Amy Lauren, Goldman, Jonathan Wade, Lisberg, Aaron Elliott, Hu-Lieskovan, Siwen, Grogan, Tristan, Gukasyan, Jaklin, Madrigal, John, Carroll, James M., Bornazyan, Krikor, Jones, Benjamin, Noor, Zorawar Singh, Zaretsky, Jesse Meir, Elashoff, David, Slamon, Dennis J., Dubinett, Steven M., Garon, Edward B.

“…Abstract only…”
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A phase II study of pembrolizumab in EGFR-mutant, PD-L1+, tyrosine kinase inhibitor (TKI) naïve patients with advanced NSCLC by Lisberg, Aaron Elliott, Cummings, Amy Lauren, Goldman, Jonathan Wade, Bornazyan, Krikor, Reese, Nicholas Dean, Wang, Tina, Coluzzi, Paul, Ledezma, Blanca A., Mendenhall, Melody A., Jones, Benjamin, Madrigal, John, Carroll, James M., Gukasyan, Jaklin, Williams, Tawny, Sauer, Lauren, Wells, Courtney L, Hardy, Ariana R, Linares, Paulina J, Adame, Carlos R., Garon, Edward B.

“…Abstract only…”
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Mutational landscape influences immunotherapy outcomes among patients with non-small-cell lung cancer with human leukocyte antigen supertype B44 by Cummings, Amy L, Gukasyan, Jaklin, Lu, Henry Y, Grogan, Tristan, Sunga, Gemalene, Fares, Charlene M, Hornstein, Nicholas, Zaretsky, Jesse, Carroll, James, Bachrach, Benjamin, Akingbemi, Wisdom O, Li, Debory, Noor, Zorawar, Lisberg, Aaron, Goldman, Jonathan W, Elashoff, David, Bui, Alex A T, Ribas, Antoni, Dubinett, Steven M, Rossetti, Maura, Garon, Edward B

“…Human leukocyte antigen (HLA)-B has been recognized as a major determinant of discrepancies in disease outcomes, and recent evidence indicates a role in immune…”
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