Search Results - "Gujarati, Nehaben A."

The complicated role of mitochondria in the podocyte by Gujarati, Nehaben A, Vasquez, Jessica M, Bogenhagen, Daniel F, Mallipattu, Sandeep K

“…Mitochondria play a complex role in maintaining cellular function including ATP generation, generation of biosynthetic precursors for macromolecules,…”
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Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation by Piret, Sian E, Attallah, Ahmed A, Gu, Xiangchen, Guo, Yiqing, Gujarati, Nehaben A, Henein, Justina, Zollman, Amy, Hato, Takashi, Ma'ayan, Avi, Revelo, Monica P, Dickman, Kathleen G, Chen, Chung-Hsin, Shun, Chia-Tung, Rosenquist, Thomas A, He, John C, Mallipattu, Sandeep K

“…Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute kidney injury and eventual fibrosis. However, transcriptional…”
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Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease by Gujarati, Nehaben A., Frimpong, Bismark O., Zaidi, Malaika, Bronstein, Robert, Revelo, Monica P., Haley, John D., Kravets, Igor, Guo, Yiqing, Mallipattu, Sandeep K.

“…Diabetic kidney disease (DKD) is the main cause of chronic kidney disease worldwide. While injury to the podocytes, visceral epithelial cells that comprise the…”
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A putative chordate luciferase from a cosmopolitan tunicate indicates convergent bioluminescence evolution across phyla by Tessler, Michael, Gaffney, Jean P., Oliveira, Anderson G., Guarnaccia, Andrew, Dobi, Krista C., Gujarati, Nehaben A., Galbraith, Moira, Mirza, Jeremy D., Sparks, John S., Pieribone, Vincent A., Wood, Robert J., Gruber, David F.

“…Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in…”
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The Novel Benzamide Derivative, VKNG-2, Restores the Efficacy of Chemotherapeutic Drugs in Colon Cancer Cell Lines by Inhibiting the ABCG2 Transporter by Narayanan, Silpa, Gujarati, Nehaben A, Wang, Jing-Quan, Wu, Zhuo-Xun, Koya, Jagadish, Cui, Qingbin, Korlipara, Vijaya L, Ashby, Jr, Charles R, Chen, Zhe-Sheng

“…The overexpression of ATP-binding cassette transporter, ABCG2, plays an important role in mediating multidrug resistance (MDR) in certain types of cancer…”
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VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study by Narayanan, Silpa, Fan, Ying-Fang, Gujarati, Nehaben A, Teng, Qiu-Xu, Wang, Jing-Quan, Cai, Chao-Yun, Yang, Yuqi, Chintalapati, Anirudh J, Lei, Yixiong, Korlipara, Vijaya L, Chen, Zhe-Sheng

“…The emergence of multidrug resistance (MDR) to chemotherapeutic drugs is a major problem in the therapy of cancer. Knowledge of the mechanisms of drug…”
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Luciferin production and luciferase transcription in the bioluminescent copepod Metridia lucens by Tessler, Michael, Gaffney, Jean P, Crawford, Jason M, Trautman, Eric, Gujarati, Nehaben A, Alatalo, Philip, Pieribone, Vincent A, Gruber, David F

“…Bioluminescent copepods are often the most abundant marine zooplankton and play critical roles in oceanic food webs. copepods exhibit particularly bright…”
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Loss of Functional SCO2 Attenuates Oxidative Stress in Diabetic Kidney Disease by Gujarati, Nehaben A, Leonardo, Alexandra R, Vasquez, Jessica M, Guo, Yiqing, Frimpong, Bismark O, Fozilov, Elbek, Revelo, Monica P, Daehn, Ilse S, He, John C, Bogenhagen, Daniel, Mallipattu, Sandeep K

“…Increased oxidative stress in glomerular endothelial cells (GEnCs) contributes to early diabetic kidney disease (DKD). While mitochondrial respiratory complex…”
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Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors by Gujarati, Nehaben A., Zeng, Leli, Gupta, Pranav, Chen, Zhe-Sheng, Korlipara, Vijaya L.

“…[Display omitted] Breast cancer resistant protein (BCRP/ABCG2), a 72kDa plasma membrane transporter protein is a member of ABC transporter superfamily…”
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Identification of Cell-Specific Transcriptomic Changes in Complement Activation and Regulation in Glomerular Microangiopathy Using Single Nuclei RNA Sequencing: SA-PO632 by Estrada, Chelsea C., Gujarati, Nehaben A., Mallipattu, Sandeep K.

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Podocyte-Mediated Proximal Tubule Preconditioning Is Protective in Diabetic Kidney Disease: TH-PO217 by Frimpong, Bismark Owusu, Gujarati, Nehaben A., Mallipattu, Sandeep K.

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Identification of Cell-Specific Transcriptomic Changes and Cross-Talk in Diabetic Mice with Podocyte-Specific Induction of KLF6 Using Single Nuclei RNA Sequencing: PO0665 by Frimpong, Bismark Owusu, Gujarati, Nehaben A., Mallipattu, Sandeep K.

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Identification of Novel Small Molecules for Podocytopathies Using a High-Throughput Screen for KLF15 Agonists: TH-PO778 by Chow, Andrew, Guo, Yiqing, Gujarati, Nehaben A., Das, Bhaskar, Mallipattu, Sandeep K.

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Podocyte-Specific Clusterin Triggers the Activation of Proximal Tubule-Specific CAMK1D Signaling to Attenuate Kidney Injury in Diabetic Kidney Disease: FR-PO342 by Gujarati, Nehaben A., Frimpong, Bismark Owusu, Zaidi, Malaika, Mallipattu, Sandeep K.

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Podocyte-Specific Induction of KLF6 Attenuates Diabetic Kidney Disease in Mice: PO0906 by Frimpong, Bismark Owusu, Gujarati, Nehaben A., Mallipattu, Sandeep K.

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Tubule-Specific Overexpression of Krüppel-Like Factor 6 (KLF6) Is Detrimental After Nephrotoxic Kidney Injury: SA-PO1003 by Piret, Sian, Davis, Merin, Gholami, Samaneh, Gujarati, Nehaben A., Frimpong, Bismark Owusu, Mallipattu, Sandeep K.

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Proximal Tubule-Specific Transcriptomic Changes Mediate Sex Differences in Susceptibility to Aristolochic Acid I-Induced AKI in Mice: TH-PO123 by Bahadur, Tej, Wang, Jiakang, Bronstein, Robert, Guo, Yiqing, Gujarati, Nehaben A., Penafiel, Monica P. Revelo, Piret, Sian, Mallipattu, Sandeep K.

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Loss of Proximal Tubular Krüppel-Like Factor 15 in Kidney Injury Is Detrimental Through Suppression of Fatty Acid Oxidation: SA-OR16 by Piret, Sian, Attallah, Ahmed A., Guo, Yiqing, Gujarati, Nehaben A., Mallipattu, Sandeep K.

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Loss of Functional SCO2 Attenuates Diabetic Kidney Disease in db/db Mice: SA-OR16 by Gujarati, Nehaben A., Leonardo, Alexandra R., Vasquez, Jessica M., Mallipattu, Sandeep K.

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Abstract 3010: VKNG 1 reverses multidrug resistance by inhibiting ABCG2 mediated drug transport in vitro and in vivo by Narayanan, Silpa, Gujarati, Nehaben A., Teng, Qiuxu, Wang, Jingquan, Cai, Chao-Yun, Yang, Yuqi, Chintalapati, Anirudh Jaganna, Korlipara, Vijaya L., Chen, Zhe-Sheng

“…Abstract The emergence of multidrug resistance (MDR) to chemotherapeutic drugs continues to be a major problem in the treatment of cancer. Drug resistance,…”
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