Search Results - "Guix, Francesc"

The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration by Guix, Francesc X.

“…The finding of an effective cure or treatment for neurodegenerative diseases is one of the biggest challenges for this century. Although these diseases show…”
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Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles by Guix, Francesc X, Corbett, Grant T, Cha, Diana J, Mustapic, Maja, Liu, Wen, Mengel, David, Chen, Zhicheng, Aikawa, Elena, Young-Pearse, Tracy, Kapogiannis, Dimitrios, Selkoe, Dennis J, Walsh, Dominic M

“…Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). A popular theory that seeks to explain the apparent…”
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Enhancing Anti-Aβ Properties of Recombinant Autoantibodies by Guix, Francesc X.

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Neuronal Prosurvival Role of Ceramide Synthase 2 by Olidogendrocyte-to-Neuron Extracellular Vesicle Transfer by Casadomé-Perales, Álvaro, Naya, Sara, Fernández-Martínez, Elisa, Mille, Bea G, Guerrero-Valero, Marta, Peinado, Héctor, Guix, Francesc X, Dotti, Carlos G, Palomer, Ernest

“…Ageing is associated with notorious alterations in neurons, i.e., in gene expression, mitochondrial function, membrane degradation or intercellular…”
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Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments by Guix, Francesc X, Sannerud, Ragna, Berditchevski, Fedor, Arranz, Amaia M, Horré, Katrien, Snellinx, An, Thathiah, Amantha, Saido, Takaomi, Saito, Takashi, Rajesh, Sundaresan, Overduin, Michael, Kumar-Singh, Samir, Radaelli, Enrico, Corthout, Nikky, Colombelli, Julien, Tosi, Sébastien, Munck, Sebastian, Salas, Isabel H, Annaert, Wim, De Strooper, Bart

“…The mechanisms behind Aβ-peptide accumulation in non-familial Alzheimer's disease (AD) remain elusive. Proteins of the tetraspanin family modulate Aβ…”
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Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity by Salas, Isabel H, Callaerts-Vegh, Zsuzsanna, Arranz, Amaia M, Guix, Francesc X, D'Hooge, Rudi, Esteban, José A, De Strooper, Bart, Dotti, Carlos G

“…Tetraspanins (Tspan) are transmembrane proteins with important scaffold and signalling functions. Deletions of Tetraspanin 6 (Tspan6) gene, a member of the…”
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Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression by Ill-Raga, Gerard, Palomer, Ernest, Wozniak, Matthew A, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Tajes, Marta, Guix, Francesc X, Galán, José J, Clarimón, Jordi, Antúnez, Carmen, Real, Luis M, Boada, Mercé, Itzhaki, Ruth F, Fandos, César, Muñoz, Francisco J

“…BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively…”
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Extracellular Vesicles Derived from Young Neural Cultures Attenuate Astrocytic Reactivity In Vitro by Almansa, Daniel, Peinado, Héctor, García-Rodríguez, Raquel, Casadomé-Perales, Álvaro, Dotti, Carlos G, Guix, Francesc X

“…Extracellular vesicles (EVs) play an important role in intercellular communication and are involved in both physiological and pathological processes. In the…”
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Could blocking the formation of amyloid channels rescue Alzheimer's phenotype? by Guix, Francesc X, Dotti, Carlos G

“…In a most simplified way, we can say that much of the symptomatology that characterizes Alzheimer's disease (AD) can be attributed to a cascade of toxic events…”
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Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity by Salas, Isabel H, Callaerts-Vegh, Zsuzsanna, Arranz, Amaia M, Guix, Francesc X, D'Hooge, Rudi, Esteban, José A, De Strooper, Bart, Dotti, Carlos G

“…[This corrects the article DOI: 10.1371/journal.pone.0171968.]…”
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YOUNG NEURAL EXTRACELLULAR VESICLES INCREASE SURVIVAL IN AGED NEURAL CELL CULTURES AND PROTECT AGAINST INFLAMMATORY STIMULI by Rodríguez, Raquel García, Cadavieco, Marta Carús, Guix, Francesc, Dotti, Carlos

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Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity by Salas, Isabel H, Callaerts-Vegh, Zsuzsanna, Arranz, Amaia M, Guix, Francesc X, D'Hooge, Rudi, Esteban, José A, De Strooper, Bart, Dotti, Carlos G

“…[This corrects the article DOI: 10.1371/journal.pone.0171968.]…”
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Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology by de Vidania, Silvia, Palomares-Perez, Irene, Frank-García, Ana, Saito, Takashi, Saido, Takaomi C, Draffin, Jonathan, Szaruga, María, Chávez-Gutierrez, Lucía, Calero, Miguel, Medina, Miguel, Guix, Francesc X, Dotti, Carlos G

“…In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid…”
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Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease by Guix, Francesc X., Wahle, Tina, Vennekens, Kristel, Snellinx, An, Chávez‐Gutiérrez, Lucía, Ill‐Raga, Gerard, Ramos‐Fernandez, Eva, Guardia‐Laguarta, Cristina, Lleó, Alberto, Arimon, Muriel, Berezovska, Oksana, Muñoz, Francisco J., Dotti, Carlos G., De Strooper, Bart

“…Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid…”
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Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral cortex of diabetic mice at the early symptomatic stage by Carús-Cadavieco, Marta, González de la Fuente, Sandra, Berenguer López, Inés, Serrano-Lope, Miguel A., Aguado, Begoña, Guix, Francesc, Palomer, Ernest, Dotti, Carlos G.

“…Analyzing changes in gene expression within specific brain regions of individuals with Type 2 Diabetes (T2DM) who do not exhibit significant cognitive deficits…”
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Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis by Ill-Raga, Gerard, Tajes, Marta, Busquets-García, Arnau, Ramos-Fernández, Eva, Vargas, Lina M, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Eraso-Pichot, Abel, Guix, Francesc X, Fandos, César, Rosen, Mark D, Rabinowitz, Michael H, Maldonado, Rafael, Alvarez, Alejandra R, Ozaita, Andrés, Muñoz, Francisco J

“…Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's…”
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Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α by Vicente, Rubén, Álvarez, Alejandra R., Muñoz, Francisco J., Menéndez, Silvia, Guix, Francesc X., ILL-Raga, Gerard, Tajes, Marta, Crepin, Giulia, Barranco-Almohalla, Alejandro, Gutiérrez, Daniela A., Picón-Pagès, Pol, Arumí-Uría, Montserrat

“…Alzheimer’s disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of…”
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Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death by ILL-Raga, Gerard, Palomer, Ernest, Ramos-Fernández, Eva, Guix, Francesc X., Bosch-Morató, Mònica, Guivernau, Biuse, Tajes, Marta, Valls-Comamala, Victòria, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Gil-Gómez, Gabriel, Lopez-Vilchez, Irene, Galan, Ana M., Alameda, Francesc, Escolar, Gines, Opazo, Carlos, Planas, Anna M., Roquer, Jaume, Valverde, Miguel A., Muñoz, Francisco J.

“…Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its…”
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Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease by Tajes, Marta, Eraso-Pichot, Abel, Rubio-Moscardó, Fanny, Guivernau, Biuse, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Guix, Francesc Xavier, Clarimón, Jordi, Miscione, Gian Pietro, Boada, Mercé, Gil-Gómez, Gabriel, Suzuki, Toshiharu, Molina, Henrik, Villà-Freixa, Jordi, Vicente, Rubén, Muñoz, Francisco J

“…Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of…”
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Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation by Guix, Francesc X., Ill-Raga, Gerard, Bravo, Ramona, Nakaya, Tadashi, de Fabritiis, Gianni, Coma, Mireia, Miscione, Gian Pietro, Villà-Freixa, Jordi, Suzuki, Toshiharu, Fernàndez-Busquets, Xavier, Valverde, Miguel A., de Strooper, Bart, Muñoz, Francisco J.

“…Alzheimer's disease neuropathology is characterized by neuronal death, amyloid β-peptide deposits and neurofibrillary tangles composed of paired helical…”
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