Sulfonyldibenzoate coordination polymers as bioactive dopants for polysaccharide films with antibacterial and antibiofilm properties

This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(6-sdba)]n (1) and [Cu(4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,...

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Bibliographic Details
Published in:	RSC applied interfaces Vol. 1; pp. 98 - 109
Main Authors:	Fernandes, Tiago A., Macedo, Filipa, Cabral, Rafaela G., Guiu, Telma, Franco, Chris H. J., Jorge, Paula, Sousa, Ana Catarina, André, Vânia, Cerca, Nuno, Kirillov, Alexander M.
Format:	Journal Article
Language:	English
Published:	Royal Society of Chemistry 17-01-2024
Online Access:	Get full text
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Summary:	This work describes the preparation, characterization, and antimicrobial properties of bioactive silver(I) and copper(II) coordination polymers (bioCPs) and derived biopolymer materials. Two bioCPs, [Ag2(6-sdba)]n (1) and [Cu(4-sdba)H2O]n·1.5nH2O (2), were assembled from metal salt precursors and 4,4-sulfonyldibenzoic acid (H2sdba). Both compounds were used as dopants for preparing hybrid biopolymer films based on agarose (AGR) or potato starch (PS) as model polysaccharide biopolymers with varying rates of degradability and silver/copper release. BioCPs and derived biopolymer films (1@[AGR]n, 2@[AGR]n, 1@[PS]n, and 2@[PS]n) with a low loading of dopant (15 wt%) show promising antibacterial activity against Gram-positive (S. aureus and S. epidermidis) and Gram-negative (E. coli and P. aeruginosa) bacteria. Silver-doped biopolymer films also totally impair the formation of bacterial biofilms, with undetectable biofilm cells in several cases (7.5log or 99.99999% inhibition). By reporting new bioCPs and biopolymer films obtained from renewable polysaccharides, this multidisciplinary work extends the application of coordination compounds as components of hybrid functional materials with antimicrobial properties and prospective biomedical relevance. This study was supported by the Foundation for Science and Technology (FCT) (projects PTDC/QUI-QIN/3898/2020, PTDC/QUI-QIN/29697/2017, UIDP/00100/2020, UIDB/00100/2020, LA/P/0056/2020, and REM2013; contracts under DL No. 57/2016, CEECIND/02725/2018, CEECIND/00283/2018 and CEECIND/00194/2020) as well as ISEL (IPL/2022/3DBioProd_ISEL, and IPL/2021/Naf4Med3D_ISEL). We thank Dr. Ivo M. F. Bragança for studying the mechanical properties.
ISSN:	2755-3701
DOI:	10.1039/D3LF00123G