Search Results - "Guirgis, Faheem"

HDL and persistent inflammation immunosuppression and catabolism syndrome by Barker, Grant, Winer, Julia R., Guirgis, Faheem W., Reddy, Srinivasa

“…This study reviews the mechanisms of HDL cholesterol immunomodulation in the context of the mechanisms of chronic inflammation and immunosuppression causing…”
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HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock by Guirgis, Faheem W, Dodani, Sunita, Leeuwenburgh, Christiaan, Moldawer, Lyle, Bowman, Jennifer, Kalynych, Colleen, Grijalva, Victor, Reddy, Srinivasa T, Jones, Alan E, Moore, Frederick A

“…High density lipoprotein (HDL) is important for defense against sepsis but becomes dysfunctional (Dys-HDL) during inflammation. We hypothesize that Dys-HDL…”
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The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients by Sterling, Sarah A., Puskarich, Michael A., Glass, Andrew F., Guirgis, Faheem, Jones, Alan E.

“…OBJECTIVE:The Third International Consensus Definitions Task Force (Sepsis-3) recently recommended changes to the definitions of sepsis. The impact of these…”
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PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort by Mitchell, Kellie A, Moore, Justin Xavier, Rosenson, Robert S, Irvin, Ryan, Guirgis, Faheem W, Shapiro, Nathan, Safford, Monika, Wang, Henry E

“…Elevated proprotein convertase subtilisin/kexin type 9 (PCSK9) levels have been associated with adverse outcomes in patients hospitalized for sepsis. PCSK9…”
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Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness by Barker, Grant, Leeuwenburgh, Christiaan, Brusko, Todd, Moldawer, Lyle, Reddy, Srinivasa T, Guirgis, Faheem W

“…In addition to their well-characterized roles in metabolism, lipids and lipoproteins have pleiotropic effects on the innate immune system. These undergo…”
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The Lipid Intensive Drug Therapy for Sepsis Phase II Pilot Clinical Trial by Guirgis, Faheem W, Black, Lauren Page, Henson, Morgan, Bertrand, Andrew, DeVos, Elizabeth, Ferreira, Jason, Gao, Hanzhi, Wu, Samuel S, Leeuwenburgh, Christiaan, Moldawer, Lyle, Moore, Frederick, Reddy, Srinivasa T

“…Low cholesterol levels in early sepsis patients are associated with mortality. We sought to test if IV lipid emulsion administration to sepsis patients with…”
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Ultrasound‐Guided Peripheral Intravenous Catheter Training Results in Physician‐Level Success for Emergency Department Technicians by Duran-Gehring, Petra, Bryant, Laurie, Reynolds, Jennifer A., Aldridge, Petra, Kalynych, Colleen J., Guirgis, Faheem W.

“…Objectives To report our success and complication rates with emergency department (ED) technician–performed ultrasound (US)‐guided peripheral intravenous (IV)…”
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Response to the Letter: “Bias estimation of predictors and internal validity of the study ‘Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis’” by Gautam, Shiva, Smotherman, Carmen, Guirgis, Faheem W.

“…[...]our team discussed several strategies with which to analyze the data prior to settling on the approach presented in the paper. Because of the repeated…”
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TRENDS IN CHOLESTEROL AND LIPOPROTEINS ARE ASSOCIATED WITH ACUTE RESPIRATORY DISTRESS SYNDROME INCIDENCE AND DEATH AMONG SEPSIS PATIENTS by Black, Lauren Page, Hopson, Charlotte, Barker, Grant, Munson, Taylor, Henson, Morgan, Bertrand, Andrew, Daly-Crews, Kimberly, Reddy, Srinivasa T, Guirgis, Faheem W

“…Objective: Compare changes in cholesterol and lipoprotein levels occurring in septic patients with and without acute respiratory distress syndrome (ARDS) and…”
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A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes by Guirgis, Faheem W, Black, Lauren Page, Henson, Morgan, Labilloy, Guillaume, Smotherman, Carmen, Hopson, Charlotte, Tfirn, Ian, DeVos, Elizabeth L, Leeuwenburgh, Christiaan, Moldawer, Lyle, Datta, Susmita, Brusko, Todd M, Hester, Alexis, Bertrand, Andrew, Grijalva, Victor, Arango-Esterhay, Alexander, Moore, Frederick A, Reddy, Srinivasa T

“…Abstract Objective Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay…”
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Cholesterol levels and long-term rates of community-acquired sepsis by Guirgis, Faheem W, Donnelly, John P, Dodani, Sunita, Howard, George, Safford, Monika M, Levitan, Emily B, Wang, Henry E

“…Dyslipidemia is a risk factor for cardiovascular disease, with elevated low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein…”
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Managing sepsis: Electronic recognition, rapid response teams, and standardized care save lives by Guirgis, Faheem W., MD, Jones, Lisa, MD, Esma, Rhemar, MD, Weiss, Alice, RN, McCurdy, Kaitlin, MD, Ferreira, Jason, PharmD, Cannon, Christina, MD, McLauchlin, Laura, DNP, Smotherman, Carmen, MS, Kraemer, Dale F., PhD, Gerdik, Cynthia, DNP, MBA, Webb, Kendall, MD, Ra, Jin, MD, Moore, Frederick A., MD, Gray-Eurom, Kelly, MD, MMM

“…Abstract Purpose Sepsis can lead to poor outcomes when treatment is delayed or inadequate. The purpose of this study was to evaluate outcomes after initiation…”
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HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study by Guirgis, Faheem W, Leeuwenburgh, Christiaan, Grijalva, Victor, Bowman, Jennifer, Kalynych, Colleen, Moldawer, Lyle, Moore, Frederick A, Reddy, Srinivasa T

“…BACKGROUND:Proper functioning of high-density lipoprotein (HDL) is necessary for protection against sepsis. However, previous work has demonstrated that HDL…”
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Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis by Padro, Teresa, Smotherman, Carmen, Gautam, Shiva, Gerdik, Cynthia, Gray-Eurom, Kelly, Guirgis, Faheem W.

“…Healthcare associated (HA) sepsis is associated with increased resource utilization and mortality compared with community acquired (CA) sepsis. The purpose of…”
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Quantitative and Qualitative Assessments of Cholesterol Association With Bacterial Infection Type in Sepsis and Septic Shock by Black, Lauren Page, Puskarich, Michael A., Henson, Morgan, Miller, Taylor, Reddy, Srinivasa T., Fernandez, Rosemarie, Guirgis, Faheem W.

“…Background: Reduced cholesterol levels are associated with increased organ failure and mortality in sepsis. Cholesterol levels may vary by infection type (gram…”
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Sequential Organ Failure Assessment Component Score Prediction of In-hospital Mortality From Sepsis by Gupta, Tushar, Puskarich, Michael A., DeVos, Elizabeth, Javed, Adnan, Smotherman, Carmen, Sterling, Sarah A., Wang, Henry E., Moore, Frederick A., Jones, Alan E., Guirgis, Faheem W.

“…Objectives: Early organ dysfunction in sepsis confers a high risk of in-hospital mortality, but the relative contribution of specific types of organ failure to…”
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The long-term burden of severe sepsis and septic shock: Sepsis recidivism and organ dysfunction by Guirgis, Faheem W, Brakenridge, Scott, Sutchu, Selina, Khadpe, Jay D, Robinson, Taylor, Westenbarger, Richard, Topp, Stephen T, Kalynych, Colleen J, Reynolds, Jennifer, Dodani, Sunita, Moore, Frederick A, Jones, Alan E

“…Severe sepsis and septic shock mortality has improved; however, rates of persistent (28-90 days) and long-term (>90 day) organ dysfunction in sepsis survivors…”
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Lipidomic changes in a novel sepsis outcome‐based analysis reveals potent pro‐inflammatory and pro‐resolving signaling lipids by Sulaiman, Dawoud, Wu, Dongyuan, Black, Lauren Page, Williams, Kevin J., Graim, Kiley, Datta, Susmita, Reddy, Srinivasa T., Guirgis, Faheem W.

“…The purpose of this study was to investigate changes in the lipidome of patients with sepsis to identify signaling lipids associated with poor outcomes that…”
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Development of a Simple Sequential Organ Failure Assessment Score for Risk Assessment of Emergency Department Patients With Sepsis by Guirgis, Faheem W., Puskarich, Michael A., Smotherman, Carmen, Sterling, Sarah A., Gautam, Shiva, Moore, Frederick A., Jones, Alan E.

“…Objectives: Sepsis-3 recommends using the quick Sequential Organ Failure Assessment (qSOFA) score followed by SOFA score for sepsis evaluation. The SOFA is…”
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Response to Editor letter “Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis” by Guirgis, Faheem W., Padro, Teresa, Smotherman, Carmen, Gautam, Shiva, Gerdik, Cynthia, Gray-Eurom, Kelly

“…Concerning the use of the Sepsis-3 criteria, we did report both SOFA and qSOFA scores on presentation and these data are presented in Table 3 of our article…”
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