Search Results - "Guiot, Marie‐Christine"

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy by Couturier, Charles P., Ayyadhury, Shamini, Le, Phuong U., Nadaf, Javad, Monlong, Jean, Riva, Gabriele, Allache, Redouane, Baig, Salma, Yan, Xiaohua, Bourgey, Mathieu, Lee, Changseok, Wang, Yu Chang David, Wee Yong, V., Guiot, Marie-Christine, Najafabadi, Hamed, Misic, Bratislav, Antel, Jack, Bourque, Guillaume, Ragoussis, Jiannis, Petrecca, Kevin

“…Cancer stem cells are critical for cancer initiation, development, and treatment resistance. Our understanding of these processes, and how they relate to…”
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Comparison of polarization properties of human adult microglia and blood-derived macrophages by Durafourt, Bryce A., Moore, Craig S., Zammit, Domenick A., Johnson, Trina A., Zaguia, Fatma, Guiot, Marie-Christine, Bar-Or, Amit, Antel, Jack P.

“…Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood‐derived macrophages participate in inflammatory responses in the CNS…”
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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers by Gruosso, Tina, Gigoux, Mathieu, Manem, Venkata Satya Kumar, Bertos, Nicholas, Zuo, Dongmei, Perlitch, Irina, Saleh, Sadiq Mehdi Ismail, Zhao, Hong, Souleimanova, Margarita, Johnson, Radia Marie, Monette, Anne, Ramos, Valentina Muñoz, Hallett, Michael Trevor, Stagg, John, Lapointe, Réjean, Omeroglu, Atilla, Meterissian, Sarkis, Buisseret, Laurence, Van den Eynden, Gert, Salgado, Roberto, Guiot, Marie-Christine, Haibe-Kains, Benjamin, Park, Morag

“…Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC)…”
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Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy by Jermyn, Michael, Mercier, Jeanne, Aubertin, Kelly, Desroches, Joannie, Urmey, Kirk, Karamchandiani, Jason, Marple, Eric, Guiot, Marie-Christine, Leblond, Frederic, Petrecca, Kevin

“…Effectiveness of surgery as a cancer treatment is reduced when all cancer cells are not detected during surgery, leading to recurrences that negatively impact…”
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A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy by Desroches, Joannie, Jermyn, Michael, Pinto, Michael, Picot, Fabien, Tremblay, Marie-Andrée, Obaid, Sami, Marple, Eric, Urmey, Kirk, Trudel, Dominique, Soulez, Gilles, Guiot, Marie-Christine, Wilson, Brian C., Petrecca, Kevin, Leblond, Frédéric

“…Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach…”
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Development and first in‐human use of a Raman spectroscopy guidance system integrated with a brain biopsy needle by Desroches, Joannie, Lemoine, Émile, Pinto, Michael, Marple, Eric, Urmey, Kirk, Diaz, Roberto, Guiot, Marie‐Christine, Wilson, Brian C., Petrecca, Kevin, Leblond, Frédéric

“…Navigation‐guided brain biopsies are the standard of care for diagnosis of several brain pathologies. However, imprecise targeting and tissue heterogeneity…”
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway by Carbonneau, Mélissa, M. Gagné, Laurence, Lalonde, Marie-Eve, Germain, Marie-Anne, Motorina, Alena, Guiot, Marie-Christine, Secco, Blandine, Vincent, Emma E., Tumber, Anthony, Hulea, Laura, Bergeman, Jonathan, Oppermann, Udo, Jones, Russell G., Laplante, Mathieu, Topisirovic, Ivan, Petrecca, Kevin, Huot, Marc-Étienne, Mallette, Frédérick A.

“…The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the…”
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Prognostic factors for progression in atypical meningioma by Shakir, Shakir I, Souhami, Luis, Petrecca, Kevin, Mansure, Jose João, Singh, Khushdeep, Panet-Raymond, Valerie, Shenouda, George, Al-Odaini, Amal A, Abdulkarim, Bassam, Guiot, Marie-Christine

“…In patients with postoperative residual atypical meningiomas, by using volumetric instead of linear measurements in follow-up imaging studies, the authors…”
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Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset of Class II BRAF Mutant Melanomas by Dankner, Matthew, Lajoie, Mathieu, Moldoveanu, Dan, Nguyen, Tan-Trieu, Savage, Paul, Rajkumar, Shivshankari, Huang, Xiu, Lvova, Maria, Protopopov, Alexei, Vuzman, Dana, Hogg, David, Park, Morag, Guiot, Marie-Christine, Petrecca, Kevin, Mihalcioiu, Catalin, Watson, Ian R, Siegel, Peter M, Rose, April A N

“…Dual MAPK pathway inhibition (dMAPKi) with BRAF and MEK inhibitors improves survival in BRAF V600E/K mutant melanoma, but the efficacy of dMAPKi in non-V600…”
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Characterization of a Raman spectroscopy probe system for intraoperative brain tissue classification by Desroches, Joannie, Jermyn, Michael, Mok, Kelvin, Lemieux-Leduc, Cédric, Mercier, Jeanne, St-Arnaud, Karl, Urmey, Kirk, Guiot, Marie-Christine, Marple, Eric, Petrecca, Kevin, Leblond, Frédéric

“…A detailed characterization study is presented of a Raman spectroscopy system designed to maximize the volume of resected cancer tissue in glioma surgery based…”
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In vivo hippocampal cornu ammonis 1–3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes by Lam, Jack, DuBois, Jonathan M., Rowley, Jared, Rousset, Olivier G., González‐Otárula, Karina A., Soucy, Jean‐Paul, Massarweh, Gassan, Hall, Jeffery A., Guiot, Marie‐Christine, Zimmermann, Maria, Minuzzi, Luciano, Rosa‐Neto, Pedro, Kobayashi, Eliane

“…Objective Previous positron emission tomography (PET) studies using [11C]ABP688 show reduced metabotropic glutamate receptor type 5 (mGluR5) allosteric binding…”
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In vivo metabotropic glutamate receptor type 5 abnormalities localize the epileptogenic zone in mesial temporal lobe epilepsy by Lam, Jack, DuBois, Jonathan M., Rowley, Jared, González‐Otárula, Karina A., Soucy, Jean‐Paul, Massarweh, Gassan, Hall, Jeffery A., Guiot, Marie‐Christine, Rosa‐Neto, Pedro, Kobayashi, Eliane

“…Objective Surgical specimens from patients with mesial temporal lobe epilepsy (MTLE) show abnormalities in tissue concentrations of metabotropic glutamate…”
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Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians by Gavino, Christina, MSc, Hamel, Nancy, MSc, Zeng, Ji Bin, PhD, Legault, Catherine, MD, Guiot, Marie-Christine, MD, PhD, Chankowsky, Jeffrey, MD, Lejtenyi, Duncan, MSc, Lemire, Martine, MD, Alarie, Isabelle, MD, Dufresne, Simon, MD, Boursiquot, Jean-Nicolas, MD, McIntosh, Fiona, MSc, Langelier, Mélanie, BScN, Behr, Marcel A., MD, Sheppard, Donald C., MD, Foulkes, William D., MBBS, PhD, Vinh, Donald C., MD

“…Background Caspase recruitment domain-containing protein 9 (CARD9) deficiency is an autosomal recessive primary immunodeficiency conferring human…”
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A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer by Savage, Paul, Blanchet-Cohen, Alexis, Revil, Timothée, Badescu, Dunarel, Saleh, Sadiq M.I., Wang, Yu-Chang, Zuo, Dongmei, Liu, Leah, Bertos, Nicholas R., Munoz-Ramos, Valentina, Basik, Mark, Petrecca, Kevin, Asselah, Jamil, Meterissian, Sarkis, Guiot, Marie-Christine, Omeroglu, Atilla, Kleinman, Claudia L., Park, Morag, Ragoussis, Jiannis

“…Therapies targeting epidermal growth factor receptor (EGFR) have variable and unpredictable responses in breast cancer. Screening triple-negative breast cancer…”
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Postsurgical seizure outcome in temporal lobe epilepsy patients with normal or subtle, nonspecific MRI findings by González Otárula, Karina A, Tan, Yee-Leng, Hall, Jeffery A, Chang, Edward F, Correa, José A, Dubeau, François, Sziklas, Viviane, Soucy, Jean-Paul, Guiot, Marie-Christine, Knowlton, Robert C, Kobayashi, Eliane

“…The authors' objective was to report postsurgical seizure outcome of temporal lobe epilepsy (TLE) patients with normal or subtle, nonspecific MRI findings and…”
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Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring by Kuzmin, Elena, Baker, Toby M., Lesluyes, Tom, Monlong, Jean, Abe, Kento T., Coelho, Paula P., Schwartz, Michael, Del Corpo, Joseph, Zou, Dongmei, Morin, Genevieve, Pacis, Alain, Yang, Yang, Martinez, Constanza, Barber, Jarrett, Kuasne, Hellen, Li, Rui, Bourgey, Mathieu, Fortier, Anne-Marie, Davison, Peter G., Omeroglu, Atilla, Guiot, Marie-Christine, Morris, Quaid, Kleinman, Claudia L., Huang, Sidong, Gingras, Anne-Claude, Ragoussis, Jiannis, Bourque, Guillaume, Van Loo, Peter, Park, Morag

“…The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize…”
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CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide by Kaur, Simran, Ramdzan, Zubaidah M, Guiot, Marie-Christine, Li, Li, Leduy, Lam, Ramotar, Dindial, Sabri, Siham, Abdulkarim, Bassam, Nepveu, Alain

“…Cut Like homeobox 1 (CUX1), which encodes an auxiliary factor in base excision repair, resides on 7q22.1, the most frequently and highly amplified chromosomal…”
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Identity and nature of neural stem cells in the adult human subventricular zone by Baig, Salma, Nadaf, Javad, Allache, Redouane, Le, Phuong U., Luo, Michael, Djedid, Annisa, Nkili-Meyong, Andriniaina, Safisamghabadi, Maryam, Prat, Alex, Antel, Jack, Guiot, Marie-Christine, Petrecca, Kevin

“…The existence of neural stem cells (NSCs) in adult human brain neurogenic regions remains unresolved. To address this, we created a cell atlas of the adult…”
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The utility of arterial spin labeling in the presurgical evaluation of poorly defined focal epilepsy in children by Lam, Jack, Tomaszewski, Patricia, Gilbert, Guillaume, Moreau, Jeremy T, Guiot, Marie-Christine, Albrecht, Steffen, Farmer, Jean-Pierre, Atkinson, Jeffrey, Saint-Martin, Christine, Wintermark, Pia, Bernhardt, Boris, Baillet, Sylvain, Dudley, Roy W R

“…The authors sought to assess the utility of arterial spin labeling (ASL) perfusion 3T-MRI for the presurgical evaluation of poorly defined focal epilepsy in…”
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Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth by Verginelli, Federica, Perin, Alessandro, Dali, Rola, Fung, Karen H., Lo, Rita, Longatti, Pierluigi, Guiot, Marie-Christine, Del Maestro, Rolando F., Rossi, Sabrina, di Porzio, Umberto, Stechishin, Owen, Weiss, Samuel, Stifani, Stefano

“…Glioblastoma (GBM) is the most common and deadly malignant brain cancer, with a median survival of <2 years. GBM displays a cellular complexity that includes…”
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