Search Results - "Guinter, Terry"

IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death by Kimura, Motoko Y, Pobezinsky, Leonid A, Guinter, Terry I, Thomas, Julien, Adams, Anthony, Park, Jung-Hyun, Tai, Xuguang, Singer, Alfred

“…Why signaling via both the receptor for interleukin 7 (IL-7R) and the T cell antigen receptor (TCR) is required for T cell homeostasis has been unclear. Singer…”
Get full text

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function by Pobezinsky, Leonid A, Etzensperger, Ruth, Jeurling, Susanna, Alag, Amala, Kadakia, Tejas, McCaughtry, Tom M, Kimura, Motoko Y, Sharrow, Susan O, Guinter, Terry I, Feigenbaum, Lionel, Singer, Alfred

“…Singer and colleagues show that let-7 microRNAs target Zbtb16 mRNA, which encodes the transcription factor PLZF, to modulate PLZF expression during the…”
Get full text

Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus by Etzensperger, Ruth, Kadakia, Tejas, Tai, Xuguang, Alag, Amala, Guinter, Terry I, Egawa, Takeshi, Erman, Batu, Singer, Alfred

“…T cells developing in the thymus are signaled during positive selection to differentiate into either CD4 + T cells or CD8 + T cells. Singer and colleagues show…”
Get full text

Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire by Van Laethem, François, Tikhonova, Anastasia N., Pobezinsky, Leonid A., Tai, Xuguang, Kimura, Motoko Y., Le Saout, Cécile, Guinter, Terry I., Adams, Anthony, Sharrow, Susan O., Bernhardt, Günter, Feigenbaum, Lionel, Singer, Alfred

“…Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not…”
Get full text

Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus by Shinzawa, Miho, Moseman, E. Ashley, Gossa, Selamawit, Mano, Yasuko, Bhattacharya, Abhisek, Guinter, Terry, Alag, Amala, Chen, Xiongfong, Cam, Maggie, McGavern, Dorian B., Erman, Batu, Singer, Alfred

“…T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals…”
Get full text

E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex by Kadakia, Tejas, Tai, Xuguang, Kruhlak, Michael, Wisniewski, Jan, Hwang, Il-Young, Roy, Sumedha, Guinter, Terry I, Alag, Amala, Kehrl, John H, Zhuang, Yuan, Singer, Alfred

“…Preselection thymocytes are normally retained in the thymic cortex, but the mechanisms responsible remain incompletely understood. We now report that deletion…”
Get full text

αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities by Tikhonova, Anastasia N., Van Laethem, François, Hanada, Ken-ichi, Lu, Jinghua, Pobezinsky, Leonid A., Hong, Changwan, Guinter, Terry I., Jeurling, Susanna K., Bernhardt, Günter, Park, Jung-Hyun, Yang, James C., Sun, Peter D., Singer, Alfred

“…Major histocompatibility complex (MHC) restriction is the cardinal feature of T cell antigen recognition and is thought to be intrinsic to αβ T cell receptor…”
Get full text

Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors by Kimura, Motoko Y, Thomas, Julien, Tai, Xuguang, Guinter, Terry I, Shinzawa, Miho, Etzensperger, Ruth, Li, Zhenhu, Love, Paul, Nakayama, Toshinori, Singer, Alfred

“…The CD4-versus-CD8 lineage ‘choice’ is a critical stage of thymocyte development. Singer and colleagues reveal that CD8 positive selection occurs in a defined…”
Get full text

Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC by Van Laethem, François, Sarafova, Sophia D., Park, Jung-Hyun, Tai, Xuguang, Pobezinsky, Leonid, Guinter, Terry I., Adoro, Stanley, Adams, Anthony, Sharrow, Susan O., Feigenbaum, Lionel, Singer, Alfred

“…The thymus generates major histocompatibility complex (MHC)-restricted αβT cells that only recognize antigenic ligands in association with MHC or MHC-like…”
Get full text

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus by Van Laethem, François, Saba, Ingrid, Lu, Jinghua, Bhattacharya, Abhisek, Tai, Xuguang, Guinter, Terry I, Engelhardt, Britta, Alag, Amala, Rojano, Mirelle, Ashe, Jennifer M, Hanada, Ken-Ichi, Yang, James C, Sun, Peter D, Singer, Alfred

“…MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins…”
Get full text

The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells by Gegonne, Anne, Tai, Xuguang, Zhang, Jinghui, Wu, Gang, Zhu, Jianjian, Yoshimoto, Aki, Hanson, Jeffrey, Cultraro, Constance, Chen, Qing-Rong, Guinter, Terry, Yang, Zhihui, Hathcock, Karen, Singer, Alfred, Rodriguez-Canales, Jaime, Tessarollo, Lino, Mackem, Susan, Meerzaman, Daoud, Buetow, Ken, Singer, Dinah S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Upregulation of CD4 Expression during MHC Class II-Specific Positive Selection Is Essential for Error-free Lineage Choice by Sarafova, Sophia D., Van Laethem, Francois, Adoro, Stanley, Guinter, Terry, Sharrow, Susan O., Feigenbaum, Lionel, Singer, Alfred

“…The lineage fate of developing thymocytes is determined by the persistence or cessation of T cell receptor (TCR) signaling during positive selection, with…”
Get full text

Modulation of Coreceptor Transcription during Positive Selection Dictates Lineage Fate Independently of TCR/Coreceptor Specificity by Sarafova, Sophia D., Erman, Batu, Yu, Qing, Van Laethem, François, Guinter, Terry, Sharrow, Susan O., Feigenbaum, Lionel, Wildt, Kathryn F., Ellmeier, Wilfried, Singer, Alfred

“…For developing T cells, coreceptor choice is matched to T cell antigen receptor (TCR) MHC specificity during positive selection in the thymus, but the…”
Get full text

Coreceptor Signal Strength Regulates Positive Selection but Does Not Determine CD4/CD8 Lineage Choice in a Physiologic In Vivo Model by Erman, Batu, Alag, Amala S, Dahle, Oyvind, van Laethem, Francois, Sarafova, Sophia D, Guinter, Terry I, Sharrow, Susan O, Grinberg, Alexander, Love, Paul E, Singer, Alfred

“…TCR signals drive thymocyte development, but it remains controversial what impact, if any, the intensity of those signals have on T cell differentiation in the…”
Get full text

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals by Tai, Xuguang, Erman, Batu, Alag, Amala, Mu, Jie, Kimura, Motoko, Katz, Gil, Guinter, Terry, McCaughtry, Tom, Etzensperger, Ruth, Feigenbaum, Lionel, Singer, Dinah S., Singer, Alfred

“…Immune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of…”
Get full text

How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion by Tai, Xuguang, Indart, Alyssa, Rojano, Mirelle, Guo, Jie, Apenes, Nicolai, Kadakia, Tejas, Craveiro, Marco, Alag, Amala, Etzensperger, Ruth, Badr, Mohamed Elsherif, Zhang, Flora, Zhang, Zhongmei, Mu, Jie, Guinter, Terry, Crossman, Assiatu, Granger, Larry, Sharrow, Susan, Zhou, Xuyu, Singer, Alfred

“…Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to…”
Get full text

Basis of CTLA-4 function in regulatory and conventional CD4+ T cells by Tai, Xuguang, Van Laethem, François, Pobezinsky, Leonid, Guinter, Terry, Sharrow, Susan O., Adams, Anthony, Granger, Larry, Kruhlak, Michael, Lindsten, Tullia, Thompson, Craig B., Feigenbaum, Lionel, Singer, Alfred

“…CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In…”
Get full text

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells by Singer, Alfred, Park, Jung-Hyun, Adoro, Stanley, Guinter, Terry, Erman, Batu, Alag, Amala S, Catalfamo, Marta, Kimura, Motoko Y, Cui, Yongzhi, Lucas, Philip J, Gress, Ronald E, Kubo, Masato, Hennighausen, Lothar, Feigenbaum, Lionel

“…Whether CD8-lineage specification and CD8 + T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that…”
Get full text

Identification of lineage-specifying cytokines that signal all CD8.sup.+-cytotoxic-lineage-fate 'decisions' in the thymus by Etzensperger, Ruth, Kadakia, Tejas, Tai, Xuguang, Alag, Amala, Guinter, Terry I, Egawa, Takeshi, Erman, Batu

“…T cells developing in the thymus are signaled during positive selection to differentiate into either CD4.sup.+ T cells or CD8.sup.+ T cells. Singer and…”
Get full text

Unraveling a Revealing Paradox by Bosselut, Remy, Guinter, Terry I., Sharrow, Susan O., Singer, Alfred

“…The mechanism by which T cell receptor specificity determines the outcome of the CD4/CD8 lineage decision in the thymus is not known. An important clue is the…”
Get full text