Search Results - "Guinn, Zachary"

IFN-γ synergism with poly I:C reduces growth of murine and human cancer cells with simultaneous changes in cell cycle and immune checkpoint proteins by Guinn, Zachary P., Petro, Thomas M.

“…Previously, we reported that IFN-γ and poly I:C, a TLR3 Pattern Recognition Receptor (PRR) agonist, reduces growth of and induces Cleaved-Caspase-3, ISG54 and…”
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Interferon regulatory factor 3 plays a role in macrophage responses to interferon-γ by Guinn, Zachary P., Petro, Thomas M.

“…[Display omitted] IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression…”
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MEK/ERK MAP kinase limits poly I:C‐induced antiviral gene expression in RAW264.7 macrophages by reducing interferon‐beta expression by Freed, Shawn M., Baldi, Danielle S., Snow, Jason A., Athen, Sierra R., Guinn, Zachary P., Pinkerton, T. Scott, Petro, Thomas M., Moore, Tyler C.

“…Toll‐like receptor 3 (TLR3) recognizes viral double‐stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that…”
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Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass by George, Nicholas M, Boerner, Brian P, Mir, Shakeel U. R, Guinn, Zachary, Sarvetnick, Nora E

“…Loss of pancreas β-cell function is the precipitating factor in all forms of diabetes. Cell replacement therapies, such as islet transplantation, remain the…”
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IFN-γ synergizes with polyI:C to reduce growth of murine and human cancer cell growth, with concomitant reductions in cyclinD1 and PD-L1 by Petro, Thomas M., Guinn, Zachary P.

“…Abstract We saw that IFN-γ synergizes with poly I:C, a TLR3 agonist, in ISG54 expression. Interestingly, ISG54 induction correlated with reduced B16 melanoma…”
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A Non-Canonical Role for Interferon Regulatory Factor 3 Downstream of the Interferon Gamma Receptor by Guinn, Zachary P., Petro, Thomas M.

“…Abstract IFN-γ promotes the expression of anti-viral and anti-tumoral genes which act intrinsically to the cell (e.g. ISG54, ISG49), as well as genes which…”
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Activation of Interferon Regulatory Factor 3 (IRF3) is Required in Both T cells and APCs for Optimal Expression of IFN-γ, IL-17, and Granzyme B during T cell responses by Petro, Thomas M, Guinn, Zachary, Lampe, Anna

“…Abstract Recently we saw a link between activation of Interferon Regulatory Factor (IRF)-3 and expression of IFN-γ, as well as Granzyme B (GrB) from T cells…”
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Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death by Mir, Shakeel U.R., George, Nicholas M., Zahoor, Lubna, Harms, Robert, Guinn, Zachary, Sarvetnick, Nora E.

“…Autophagy, a cellular recycling process responsible for turnover of cytoplasmic contents, is critical for maintenance of health. Defects in this process have…”
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IRF3 contributes to IFN-γ expression during B16F10 tumor growth and also IFN-γ-dependent reduction in B16 tumor cell growth by Petro, Thomas M, Brown, Deborah M, Guinn, Zachary

“…Abstract Previously, we reported in C57Bl/6 (B6) and IRF3KO mice that Interferon Regulatory Factor (IRF-3) contributes to control of B16 melanoma tumor growth…”
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Synergistic enhancement of ISG54/ISRE promoter activity with combinations of Pattern Recognition Receptor agonists and Interferon-gamma by Guinn, Zachary P, Brown, Deborah M, Petro, Thomas M

“…Abstract Induction of interferon stimulated genes (ISG)-54, which depends on activation of Interferon Regulatory Factor 3 (IRF-3), is critical for innate…”
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Activation of IRF3 contributes to IFN-γ and ISG54 expression during the immune responses to B16F10 tumor growth by Guinn, Zachary, Brown, Deborah M., Petro, Thomas M.

“…Interferon Regulatory Factor (IRF-3) has been shown to contribute to immune control of B16 melanoma tumor growth. We have shown previously that IRF-3 has a…”
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Chlorovirus Acceleration of Motor Neuron Disease in SOD1G93A Transgenic Mice may Clarify some of the Augmented anti-Chlorovirus Serology in Amyotrophic Lateral Sclerosis Patients by Petro, Thomas M, Pattee, Gary L., Guinn, Zachary P., Agarkova, Irina V., Dunigan, David D., Van Etten, James

“…Abstract Infections and inflammatory responses may contribute to motor neuron diseases (MND), such as Amyotrophic Lateral Sclerosis (ALS). A portion of…”
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Activation of IRF3 contributes to IFN-? and ISG54 expression during the immune responses to B16F10 tumor growth by Guinn, Zachary, Brown, Deborah M, Petro, Thomas M

“…Interferon Regulatory Factor (IRF-3) has been shown to contribute to immune control of B16 melanoma tumor growth. We have shown previously that IRF-3 has a…”
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Increased expression of IL-18 in the serum and islets of type 1 diabetics by Harms, Robert Z., Yarde, Danielle N., Guinn, Zachary, Lorenzo-Arteaga, Kristina M., Corley, Kevin P., Cabrera, Monina S., Sarvetnick, Nora E.

“…•We analyzed IL-18 levels in the plasma of juveniles with type 1 diabetes (T1D).•Increased IL-18 expression, but not IL-18BP or IL-37, was found in T1D vs…”
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