Search Results - "Guindon, Yvan"

Synthesis of 4'-Thionucleoside Analogues Bearing a C2' Stereogenic All-Carbon Quaternary Center by Eymard, Carla, Manchoju, Amarender, Almazloum, Abir, Dostie, Starr, Prévost, Michel, Nemer, Mona, Guindon, Yvan

“…The design of novel 4'-thionucleoside analogues bearing a C2' stereogenic all-carbon quaternary center is described. The synthesis involves a highly…”
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Nucleotide Analogues Bearing a C2' or C3'-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors by Manchoju, Amarender, Zelli, Renaud, Wang, Gang, Eymard, Carla, Oo, Adrian, Nemer, Mona, Prévost, Michel, Kim, Baek, Guindon, Yvan

“…The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2' or C3' is described. The construction of this…”
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Dual-Face Nucleoside Scaffold Featuring a Stereogenic All-Carbon Quaternary Center. Intramolecular Silicon Tethered Group-Transfer Reaction by Tambutet, Guillaume, Becerril-Jiménez, Fabiola, Dostie, Starr, Simard, Ryan, Prévost, Michel, Mochirian, Philippe, Guindon, Yvan

“…The design of a novel nucleoside scaffold that exhibits an all-carbon quaternary center is reported. This allows for both α- and β-anomers of a given…”
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Synthesis of nucleoside analogues using acyclic diastereoselective reactions by Lussier, Tommy, Waltz, Marie-Ève, Freure, Garrett, Mochirian, Philippe, Dostie, Starr, Prévost, Michel, Guindon, Yvan

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A Bidirectional Approach to the Synthesis of Polypropionates: Synthesis of C1–C13 Fragment of Zincophorin and Related Isomers by Mochirian, Philippe, Godin, François, Katsoulis, Ioannis, Fontaine, Isabelle, Brazeau, Jean-François, Guindon, Yvan

“…The structure–activity study of a bioactive natural product containing polypropionate subunits requires that its stereoisomers also be evaluated. Therefore, a…”
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Diastereoselective Radical Hydrogen Transfer Reactions using N‑Heterocyclic Carbene Boranes by Tambutet, Guillaume, Guindon, Yvan

“…Reported herein are the first diastereoselective and Lewis acid-mediated radical reactions of N-heterocyclic carbene (NHC) boranes. We applied these reactions…”
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Synthesis of 2,3-Anti-3,4-anti and 2,3-Anti-3,4-syn Propionate Motifs:  A Diastereoselective Tandem Sequence of Mukaiyama and Free-Radical-Based Hydrogen Transfer Reactions by Guindon, Yvan, Prévost, Michel, Mochirian, Philippe, Guérin, Brigitte

“…Reported herein is a strategy employing a Mukaiyama reaction in tandem with a hydrogen transfer reaction for the elaboration of 2,3-anti-3,4-anti and…”
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Synthesis of Propionate Motifs:  Diastereoselective Tandem Reactions Involving Anionic and Free Radical Based Processes by Guindon, Yvan, Houde, Karine, Prévost, Michel, Cardinal-David, Benoit, Landry, Serge R, Daoust, Benoit, Bencheqroun, Mohammed, Guérin, Brigitte

“…Reported herein is a strategy employing a Mukaiyama reaction in tandem with a hydrogen transfer reaction for the elaboration of propionate motifs. The nature…”
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Synthesis of polypropionate motifs containing the anti– anti unit by Mochirian, Philippe, Cardinal-David, Benoit, Guérin, Brigitte, Prévost, Michel, Guindon, Yvan

“…Reported herein is the iteration of a strategy employing a Mukaiyama reaction in tandem with a hydrogen transfer reaction for the elaboration of four…”
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Sialyl Lewis x Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation by Joyal, Mathieu, Simard, Ryan D., Maharsy, Wael, Prévost, Michel, Nemer, Mona, Guindon, Yvan

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Stereocontrol in Radical Processes through the Exocyclic Effect:  Dual Role of Triethylboron as Radical Initiator and in Situ Derivatization Agent by Bouvier, Jean-Pierre, Jung, Grace, Liu, Ziping, Guérin, Brigitte, Guindon, Yvan

“…The diastereoselectivity of radical processes involving 1,3-diols is increased significantly with a simple and efficient strategy using the exocyclic effect…”
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Synthesis of Sialyl Lewis X Mimetics with E- and P-Selectin Binding Properties and Immunosuppressive Activity by Simard, Ryan D, Joyal, Mathieu, Beaugrand, Thomas, Gauthier, Julien, Hardine, Elodie, Desriac, Axelle, Buffet, Charles-Henri, Prévost, Michel, Nemer, Mona, Guindon, Yvan

“…E- and P-selectins are adhesion proteins implicated in immune cell recruitment at sites of infection, making them important drug targets for diseases involving…”
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Sialyl LewisX glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites by Belouin, Audrey, Simard, Ryan D., Joyal, Mathieu, Maharsy, Wael, Lau, Alice, Prévost, Michel, Nemer, Mona, Guindon, Yvan

“…Neutrophil binding to vascular P- and E-selectin is the rate-limiting step in the recruitment of immune cells to sites of inflammation. Many diseases,…”
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The Exo-Cyclic Effect:  Strategy Employing in Situ Derivatization or Lewis Acid Complexation to Enhance Stereoselectivity in Hydrogen Transfer Reactions by Guindon, Yvan, Liu, Ziping, Jung, Grace

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Synthesis of Sialyl LewisX Mimetics with E- and P‑Selectin Binding Properties and Immunosuppressive Activity by Simard, Ryan D., Joyal, Mathieu, Beaugrand, Thomas, Gauthier, Julien, Hardine, Elodie, Desriac, Axelle, Buffet, Charles-Henri, Prévost, Michel, Nemer, Mona, Guindon, Yvan

“…E- and P-selectins are adhesion proteins implicated in immune cell recruitment at sites of infection, making them important drug targets for diseases involving…”
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Diastereoselective Synthesis of Arabino- and Ribo-like Nucleoside Analogues Bearing a Stereogenic C3′ All-Carbon Quaternary Center by Lussier, Tommy, Manchoju, Amarender, Wang, Gang, Dostie, Starr, Foster, Scott, Mochirian, Philippe, Prévost, Michel, Guindon, Yvan

“…The synthesis of novel nucleoside analogues bearing a C3′ all-carbon quaternary center and a C2′-hydroxy substituent is described. The all-carbon stereogenic…”
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Photoredox-Catalyzed Stereoselective Radical Reactions to Synthesize Nucleoside Analogues with a C2′-Stereogenic All-Carbon Quaternary Center by Becerril-Jiménez, Fabiola, Lussier, Tommy, Leblanc, Louis, Eymard, Carla, Dostie, Starr, Prévost, Michel, Guindon, Yvan

“…The design of novel nucleoside analogues bearing a C2′ all-carbon quaternary center is described. The construction of this all-carbon stereogenic center…”
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Diastereoselective Synthesis of C2′-Fluorinated Nucleoside Analogues Using an Acyclic Approach by Dostie, Starr, Prévost, Michel, Mochirian, Philippe, Tanveer, Kashif, Andrella, Nicholas, Rostami, Ariana, Tambutet, Guillaume, Guindon, Yvan

“…Nucleoside analogues bearing a fluorine in the C2′-position have been synthesized by SN2-like cyclizations of acyclic thioaminal precursors. This strategy…”
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The Exocyclic Effect:  Protecting Group Strategy to Enhance Stereoselectivity in Hydrogen Transfer Reactions of Acyclic Free Radicals by Guindon, Yvan, Faucher, Anne-Marie, Bourque, Élyse, Caron, Valérie, Jung, Grace, Landry, Serge R

“…To enhance the diastereoselectivity of the hydrogen transfer reaction of acyclic substrates bearing 1,2- or 1,3-diols, the feasibility of a strategy employing…”
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Sialyl Lewis X glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites by Belouin, Audrey, Simard, Ryan D, Joyal, Mathieu, Maharsy, Wael, Lau, Alice, Prévost, Michel, Nemer, Mona, Guindon, Yvan

“…Neutrophil binding to vascular P- and E-selectin is the rate-limiting step in the recruitment of immune cells to sites of inflammation. Many diseases,…”
Get full text