Search Results - "Guinan, EC"

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers by Stolpen, AH, Guinan, EC, Fiers, W, Pober, JS

“…Human endothelial cells (HECs) in confluent primary culture reproduce the epithelioid organization of the vascular lining in situ. The addition of greater than…”
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Pivotal Role of the B7:CD28 Pathway in Transplantation Tolerance and Tumor Immunity by Guinan, Eva C., Gribben, John G., Boussiotis, Vicki A., Freeman, Gordon J., Nadler, Lee M.

“…The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that…”
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Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation by TSE, William T, PENDLETON, John D, BEYER, Wendy M, EGALKA, Matthew C, GUINAN, Eva C

“…Marrow stromal cells (MSC) can differentiate into multiple mesenchymal tissues. To assess the feasibility of human MSC transplantation, we evaluated the in…”
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Contribution of bone marrow-derived endothelial cells to human tumor vasculature by Lengauer, Christoph, Peters, Brock A, Diaz, Luis A, Polyak, Kornelia, Meszler, Leslie, Romans, Kathy, Guinan, Eva C, Antin, Joseph H, Myerson, David, Hamilton, Stanley R, Vogelstein, Bert, Kinzler, Kenneth W

“…It has been shown that bone marrow-derived stem cells can form a major fraction of the tumor endothelium in mouse tumors. To determine the role of such cells…”
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Allogeneic Hematopoietic Cell Transplantation for Fanconi Anemia in Patients With Pretransplantation Cytogenetic Abnormalities, Myelodysplastic Syndrome, or Acute Leukemia by AYAS, Mouhab, SABER, Wael, AL-SERAIHY, Amal, BATTIWALLA, Minoo, CAMITTA, Bruce M, OLSSON, Richard, BAJWA, Rajinder S, BONFIM, Carmem M, PASQUINI, Ricardo, MACMILLAN, Margaret L, GEORGE, Biju, COPELAN, Edward A, DAVIES, Stella M, WIRK, Baldeep, AL JEFRI, Abdullah, FASTH, Anders L, GUINAN, Eva C, HORN, Biljana N, LEWIS, Victor A, SLAVIN, Shimon, STEPENSKY, Polina, BIERINGS, Marc, GALE, Robert Peter, HARRIS, Richard E, HALE, Gregory A, SOCIE, Gerard, LERADEMACHER, Jennifer, THAKAR, Monica, JOACHIM, H, DEEG, J

“…Allogeneic hematopoietic cell transplantation (HCT) can cure bone marrow failure in patients with Fanconi anemia (FA). Data on outcomes in patients with…”
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17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli by Palmer, Christine D., Mancuso, Christy J., Weiss, Jerrold P., Serhan, Charles N., Guinan, Eva C., Levy, Ofer

“…Lipoxins and resolvins regulate primary human mϕ responses to E. coli to enhance TNF production and phagocytic killing while reducing TNF production to…”
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Complete Blockade of B7 Family-Mediated Costimulation Is Necessary to Induce Human Alloantigen-Specific Anergy: A Method to Ameliorate Graft-Versus-Host Disease and Extend the Donor Pool by Gribben, John G., Guinan, Eva C., Boussiotis, Vassiliki A., Ke, Xiao-Yan, Linsley, Letitia, Sieff, Colin, Gray, Gary S., Freeman, Gordon J., Nadler, Lee M.

“…Graft-versus-host disease (GVHD) is initiated by adoptively transferred donor T cells that recognize host alloantigens. Whereas the absence of donor T-cell…”
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Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome by Richardson, Paul G., Murakami, Carol, Jin, Zhezhen, Warren, Diane, Momtaz, Parisa, Hoppensteadt, Deborah, Elias, Anthony D., Antin, Joseph H., Soiffer, Robert, Spitzer, Thomas, Avigan, David, Bearman, Scott I., Martin, Paul L., Kurtzberg, Joanne, Vredenburgh, James, Chen, Allen R., Arai, Sally, Vogelsang, Georgia, McDonald, George B., Guinan, Eva C.

“…Veno-occlusive disease (VOD) is the most common regimen-related toxicity accompanying stem cell transplantation (SCT). Severe VOD complicated by multisystem…”
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Transplantation of Anergic Histoincompatible Bone Marrow Allografts by Guinan, Eva C, Boussiotis, Vassiliki A, Neuberg, Donna, Brennan, Lisa LaVita, Hirano, Naoto, Nadler, Lee M, Gribben, John G

“…Successful transplantation of organs requires the use of agents capable of suppressing the immune response against alloantigens. 1 – 3 Use of these nonspecific…”
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Cyclophosphamide Cardiotoxicity: An Analysis of Dosing as a Risk Factor by Goldberg, Mark A., Antin, Joseph H., Guinan, Eva C., Rappeport, Joel M.

“…Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide (CYA) which is usually calculated based on the…”
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Autoantibodies frequently detected in patients with aplastic anemia by Hirano, Naoto, Butler, Marcus O., von Bergwelt-Baildon, Michael S., Maecker, Britta, Schultze, Joachim L., O'Connor, Kevin C., Schur, Peter H., Kojima, Seiji, Guinan, Eva C., Nadler, Lee M.

“…Although accumulating evidence strongly suggests that aplastic anemia (AA) is a T cell-mediated autoimmune disease, no target antigens have yet been described…”
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Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation by Molrine, Deborah C., Antin, Joseph H., Guinan, Eva C., Soiffer, Robert J., MacDonald, Kristin, Malley, Richard, Malinoski, Frank, Trocciola, Susan, Wilson, Marjorie, Ambrosino, Donna M.

“…Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk for infections with Streptococcus pneumoniaeand have long-lasting, impaired…”
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Herpes zoster infection in the post-hematopoietic stem cell transplant pediatric population may be preceded by transaminitis: an institutional experience by BERMAN, J. N, WANG, M, BERRY, W, NEUBERG, D. S, GUINAN, E. C

“…Herpes zoster (HZ), a varicella-zoster virus reactivation, frequently complicates hematopoietic stem cell transplantation (HSCT). Its incidence, complications,…”
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Treatment of severe veno-occlusive disease with defibrotide : Compassionate use results in response without significant toxicity in a high-risk population by RICHARDSON, P. G, ELIAS, A. D, SOIFFER, R, VREDENBURGH, J, LILL, M, WOOLFREY, A. E, BEARMAN, S. I, LACOBELLI, M, FAREED, J, GUINAN, E. C, KRISHNAN, A, WHEELER, C, NATH, R, HOPPENSTEADT, D, KINCHLA, N. M, NEUBERG, D, WALLER, E. K, ANTIN, J. H

“…Hepatic veno-occlusive disease (VOD) is the most common of the regimen-related toxicities accompanying stem cell transplantation (SCT). Despite aggressive…”
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Presence of anti‐kinectin and anti‐PMS1 antibodies in Japanese aplastic anaemia patients by Hirano, Naoto, Butler, Marcus O., Guinan, Eva C., Nadler, Lee M., Kojima, Seiji

“…Summary While anti‐kinectin antibodies are frequently found in aplastic anaemia (AA) patients from the US (39%), we detected antibodies in only three of 30…”
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Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia by Haining, W. Nicholas, Neuberg, Donna S., Keczkemethy, Heather L., Evans, John W., Rivoli, Stephen, Gelman, Rebecca, Rosenblatt, Howard M., Shearer, William T., Guenaga, Javier, Douek, Daniel C., Silverman, Lewis B., Sallan, Stephen E., Guinan, Eva C., Nadler, Lee M.

“…Despite profound T-cell immunodeficiency, most patients treated with chemotherapy do not succumb to infection. The basis for residual protective immunity in…”
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Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation by Haining, W. Nicholas, Evans, John W., Seth, Nilufer P., Callaway, G. Derek, Wucherpfennig, Kai W., Nadler, Lee M., Guinan, Eva C.

“…Summary Quantitative assessment of immunogen‐specific T cell responses may provide a meaningful surrogate marker of functional immunity in patients following…”
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Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia by Haining, W. Nicholas, Cardoso, Angelo A., Keczkemethy, Heather L., Fleming, Mark, Neuberg, Donna, DeAngelo, Daniel J., Stone, Richard M., Galinsky, Ilene, Silverman, Lewis B., Sallan, Stephen E., Nadler, Lee M., Guinan, Eva C.

“…We and others have shown that B cell precursor acute lymphoblastic leukemia cells (ALL) stimulated with CD40 ligand become efficient antigen-presenting cells…”
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Homozygous alpha-thalassemia treated with intrauterine transfusions and postnatal hematopoietic stem cell transplantation by Thornley, I, Lehmann, L, Ferguson, W S, Davis, I, Forman, E N, Guinan, E C

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Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood by BOURQUIN, J. P, THORNLEY, I, NEUBERG, D, BRENNAN, L, KUNG, A, CLARK, J, LEHMANN, L, GUINAN, E. C

“…The optimal therapy for children with relapsed or refractory acute promyelocytic leukemia (APL) is unclear. We therefore reviewed our institutional outcomes…”
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