Search Results - "Guin, Srimanta"
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Toolbox for Distal C–H Bond Functionalizations in Organic Molecules
Published in Chemical reviews (23-03-2022)“…Transition-metal-catalyzed C–H activation has developed a contemporary approach to the omnipresent area of retrosynthetic disconnection. Scientific researchers…”
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2
Alkyne Linchpin Strategy for Drug:Pharmacophore Conjugation: Experimental and Computational Realization of a Meta-Selective Inverse Sonogashira Coupling
Published in Journal of the American Chemical Society (26-02-2020)“…The late-stage functionalization (LSF) of pharmaceutical and agrochemical compounds by the site-selective activation of C–H bonds provides access to diverse…”
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3
Four Tandem C–H Activations: A Sequential C–C and C–O Bond Making via a Pd-Catalyzed Cross Dehydrogenative Coupling (CDC) Approach
Published in Organic letters (19-10-2012)“…An unprecedented aroylation at the ortho C–H bond with respect to a directing group has been accomplished via a Pd(II)-catalyzed cross dehydrogenative coupling…”
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4
Cu(II) Catalyzed Imine C–H Functionalization Leading to Synthesis of 2,5-Substituted 1,3,4-Oxadiazoles
Published in Organic letters (18-11-2011)“…A direct access to symmetrical and unsymmetrical 2,5-disubstituted [1,3,4]-oxadiazoles has been accomplished through an imine C–H functionalization of…”
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5
Expanding chemical space by para-C−H arylation of arenes
Published in Nature communications (08-07-2022)“…Biaryl scaffolds are privileged templates used in the discovery and design of therapeutics with high affinity and specificity for a broad range of protein…”
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6
Tandem dehydrogenation-olefination-decarboxylation of cycloalkyl carboxylic acids via multifold C–H activation
Published in Nature communications (25-06-2024)“…Dehydrogenation chemistry has long been established as a fundamental aspect of organic synthesis, commonly encountered in carbonyl compounds. Transition metal…”
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Author Correction: Expanding chemical space by para-C−H arylation of arenes
Published in Nature communications (25-08-2022)Get full text
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8
A Copper-Catalyzed Synthesis of 3‑Aroylindoles via a sp3 C–H Bond Activation Followed by C–C and C–O Bond Formation
Published in Organic letters (19-04-2013)“…An efficient Cu(I)-catalyzed synthesis of 3-aroylindoles has been achieved from o-alkynylated N,N-dimethylamines via a sp3 C–H bond activation α to the…”
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9
Diverse strategies for transition metal catalyzed distal C(sp)-H functionalizations
Published in Chemical science (Cambridge) (28-09-2020)“…Transition metal catalyzed C(sp 3 )-H functionalization is a rapidly growing field. Despite severe challenges, distal C-H functionalizations of aliphatic…”
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10
Highvalent 3d metal-oxo mediated C–H halogenation: Biomimetic approaches
Published in Coordination chemistry reviews (01-04-2020)“…•Biomimetic halogenation by metal-oxo complexes resembling active sites of halogenase.•High-valent manganese-porphyrins show superior reactivity towards…”
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11
Experimental and Computational Exploration of para‐Selective Silylation with a Hydrogen‐Bonded Template
Published in Angewandte Chemie International Edition (20-11-2017)“…The regioselective conversion of C−H bonds into C−Si bonds is extremely important owing to the natural abundance and non‐toxicity of silicon. Classical…”
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12
Chelation‐Assisted Palladium‐Catalyzed γ‐Arylation of Aliphatic Carboxylic Acid Derivatives
Published in Advanced synthesis & catalysis (17-04-2017)“…A palladium(II)‐catalyzed protocol for the highly regioselective remote γ‐C–H arylation of aliphatic carboxylic acid has been disclosed. The 8‐aminoquinoline…”
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13
Unveiling catalyst-free electro-photochemical reactivity of aryl diazoesters and facile synthesis of oxazoles, imide-fused pyrroles and tetrahydro-epoxy-pyridines via carbene radical anions
Published in Chemical science (Cambridge) (14-06-2023)“…Herein, we report a reagent-less (devoid of catalyst, supporting electrolyte, oxidant and reductant) electro-photochemical (EPC) reaction [electricity (50 μA)…”
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14
Nondirected C–H/C–F Coupling for the Synthesis of α‑Fluoro Olefinated Arenes
Published in ACS catalysis (03-11-2023)“…The fluorinated entities are considered a privileged structure class in the field of medicinal chemistry because of the amplified bioactivity they exhibit. In…”
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Promoting Highly Diastereoselective γ‑C–H Chalcogenation of α‑Amino Acids and Aliphatic Carboxylic Acids
Published in ACS catalysis (06-04-2018)“…A Pd(II)-catalyzed highly regioselective γ-chalcogenation, thioarylation, and selenoarylation of aliphatic carboxylic acids has been demonstrated. The present…”
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16
Copper-Catalyzed Esterification of Alkylbenzenes with Cyclic Ethers and Cycloalkanes via C(sp3)–H Activation Following Cross-Dehydrogenative Coupling
Published in Organic letters (06-06-2014)“…A copper-catalyzed cross-dehydrogenative coupling strategy has been developed for the synthesis of two classes of esters from simple solvents. The reaction of…”
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17
Unveiling catalyst-free electro-photochemical reactivity of aryl diazoesters and facile synthesis of oxazoles, imide-fused pyrroles and tetrahydro-epoxy-pyridines carbene radical anions
Published in Chemical science (Cambridge) (14-06-2023)“…Herein, we report a reagent-less (devoid of catalyst, supporting electrolyte, oxidant and reductant) electro-photochemical (EPC) reaction [electricity (50 A)…”
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18
Copper Catalyzed Oxidative Esterification of Aldehydes with Alkylbenzenes via Cross Dehydrogenative Coupling
Published in Organic letters (03-08-2012)“…Copper(II) as the catalyst in a cross dehydrogenative coupling (CDC) reaction has been demonstrated for the synthesis of benzylic esters using aldehydes and…”
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Experimental and Computational Studies on Remote γ‑C(sp3)–H Silylation and Germanylation of Aliphatic Carboxamides
Published in ACS catalysis (01-12-2017)“…A Pd(II)-catalyzed protocol for highly regioselective distal γ-C–H silylation and germanylation of aliphatic carboxylic acids is reported. Bidentate…”
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Photoinduced [3+2] Cycloaddition of Carbenes and Nitriles: A Versatile Approach to Oxazole Synthesis
Published in Angewandte Chemie International Edition (27-11-2023)“…We have developed a photoinduced protocol for the synthesis of pharmaceutically important oxazole molecules using diazo‐ and nitrile‐containing reactants. The…”
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